Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alsterpaullone
go back to main search page
Accession:CHEBI:138488 term browser browse the term
Definition:An organic heterotetracyclic compound that is 1,3-dihydro-2H-1-benzazepin-2-one which shares its 4-5 bond with the 3-2 bond of 5-nitro-1H-indole.
Synonyms:related_synonym: 14-nitro-8,18-diazatetracyclo[9.7.0.0({2,7}).0({12,17})]octadeca-1(11),2,4,6,12(17),13,15-heptaen-9-one;   9-NITRO-5,12-DIHYDRO-7H-BENZO[2,3]AZEPINO[4,5-B]INDOL-6-ONE;   9-nitro-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one;   9-nitro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one;   9-nitropaullone;   Formula=C16H11N3O3;   InChI=1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20);   InChIKey=OLUKILHGKRVDCT-UHFFFAOYSA-N;   SMILES=C12=CC=C(C=C2C=3CC(NC4=CC=CC=C4C3N1)=O)[N+](=O)[O-]
 alt_id: CHEBI:40939
 xref: CAS:237430-03-4;   Chemspider:4185120;   DrugBank:DB04014;   LINCS:LSM-6558
 xref_mesh: MESH:C120793
 xref: PDB:1Q3W;   PDBeChem:ATU;   PMID:10425100;   PMID:12669310;   PMID:20334651;   PMID:22052821;   PMID:23577282;   PMID:26061748;   PMID:26442525;   Pubchem:24890918;   Reaxys:8340480



show annotations for term's descendants           Sort by:
alsterpaullone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor increases activity ISO alsterpaullone analog results in increased activity of AR protein CTD PMID:21111724 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Casp3 caspase 3 multiple interactions EXP alsterpaullone inhibits the reaction [Colchicine results in increased activity of CASP3 protein] CTD PMID:20300959 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity ISO alsterpaullone results in decreased activity of CDK2 protein CTD PMID:12534346 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity ISO alsterpaullone results in decreased activity of GSK3B protein CTD PMID:12534346 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 increases expression ISO alsterpaullone results in increased expression of KLK3 mRNA CTD PMID:21111724 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases activity ISO alsterpaullone results in decreased activity of LCK protein CTD PMID:12534346 NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794
JBrowse link
G Tp53 tumor protein p53 affects localization
multiple interactions
ISO alsterpaullone affects the localization of TP53 protein
alsterpaullone results in decreased degradation of and results in increased expression of TP53 protein
CTD PMID:16055726 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        biochemical role 19588
          apoptosis inducer 13641
            alsterpaullone 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      carboxylic acid 18646
                                        carboacyl group 17727
                                          univalent carboacyl group 17727
                                            carbamoyl group 17575
                                              carboxamide 17575
                                                lactam 8395
                                                  paullone 47
                                                    alsterpaullone 7
paths to the root