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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:138435 term browser browse the term
Definition:A secondary amino compound consisting of two molecules of tacrine that are linked together through their exocyclic amino groups by a heptane-1,7-diyl chain. Bis(7)-tacrine is an acetylcholinesterase (AChE)inhibitor (IC50 0.40 nM, >1,000 times more potent than tacrine). It has also been found to protect against H2O2 -induced apoptosis in rat pheochromocytoma cells.
Synonyms:exact_synonym: N,N'-di(1,2,3,4-tetrahydroacridin-9-yl)heptane-1,7-diamine
 related_synonym: B7T;   Formula=C33H40N4;   InChI=1S/C33H40N4/c1(2-12-22-34-32-24-14-4-8-18-28(24)36-29-19-9-5-15-25(29)32)3-13-23-35-33-26-16-6-10-20-30(26)37-31-21-11-7-17-27(31)33/h4,6,8,10,14,16,18,20H,1-3,5,7,9,11-13,15,17,19,21-23H2,(H,34,36)(H,35,37);   InChIKey=ITZOKHKOFJOBFS-UHFFFAOYSA-N;   N,N'-bis(1,2,3,4-tetrahydro-9-acridinyl)-1,7-heptanediamine;   SMILES=C(CCCNC=1C2=CC=CC=C2N=C3CCCCC31)CCCNC=4C5=CC=CC=C5N=C6CCCCC64;   bis(7)-tetrahydroaminacrine;   heptylene-bis(tacrine)
 alt_id: CHEBI:40503
 xref: Chemspider:7828118;   PDBeChem:AA7;   PMID:10208549;   PMID:10452094;   PMID:16543809;   PMID:17449090;   PMID:17530875;   PMID:19393253;   PMID:20043893;   PMID:20199668;   PMID:20486153;   PMID:21535411;   PMID:22330749;   PMID:22553626;   PMID:23832279;   PMID:26043757;   PMID:28294041;   PMID:28571743;   Reaxys:7608979

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Path 1
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  CHEBI ontology 19821
    role 19769
      biological role 19769
        inhibitor 18592
          apoptosis inhibitor 6899
            bis(7)-tacrine 0
Path 2
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  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  organic heteropolycyclic compound 18064
                                    organic heterotricyclic compound 14645
                                      dibenzopyridine 154
                                        acridines 121
                                          tacrine 65
                                            bis(7)-tacrine 0
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