isoprostane - Ontology Report - Rat Genome Database

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	isoprostane	go back to main search page
Accession:	CHEBI:138408	browse the term
Definition:	Any icosanoid with a prostaglandin-like structure formed in vivo by non-enzymatic free radical-catalysed reactions involving peroxidation of essential fatty acids (mainly arachidonic acid but also other fatty acids with 3 or more double bonds). Isoprostanes are abundant in tissues and fluids and have immunomodulating activity. Their concentration is dependent on the amount of oxidative stress and may be upregulated in certain diseases such as cancer, cardiovascular and neurological disorders.
Synonyms:	related_synonym:	IsoPs; isoprostanes
	xref:	PMID:10385607; PMID:12088281; PMID:12751772; PMID:15037155; PMID:15037162; PMID:15650410; PMID:15780831; PMID:16382569; PMID:18030056; PMID:18285331; PMID:20951733; PMID:21848345; Wikipedia:Isoprostane

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Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	5052
chemical entity	5080
atom	5043
nonmetal atom	5006
carbon atom	4954
organic molecular entity	4926
lipid	4408
fatty acid derivative	91
icosanoid	27
isoprostane	0
F2-isoprostane +	0
Path 2
Term	Annotations
CHEBI ontology	5052
subatomic particle	5043
composite particle	5043
hadron	5071
baryon	5043
nucleon	5043
atomic nucleus	5043
atom	5043
main group element atom	5013
p-block element atom	5010
carbon group element atom	4927
carbon atom	4954
organic molecular entity	4926
heteroorganic entity	4768
organochalcogen compound	4730
organooxygen compound	4692
carbon oxoacid	368
carboxylic acid	364
monocarboxylic acid	206
fatty acid	131
fatty acid derivative	91
icosanoid	27
isoprostane	0
F2-isoprostane +	0

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CHEBI ONTOLOGY - ANNOTATIONS