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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:octahydronaphthalenes
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Accession:CHEBI:138397 term browser browse the term
Definition:Any carbobycyclic compound that is an octahydronaphthalene or a compound obtained from an octahydronaphthalene by formal substitution of one or more hydrogens.


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(+)-artemisinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cebpa CCAAT/enhancer binding protein alpha decreases expression
multiple interactions		 ISO [artemisic acid results in decreased expression of CEBPA mRNA] which results in decreased expression of HMGCR mRNA; artemisic acid results in decreased expression of CEBPA mRNA
[[artemisic acid results in decreased expression of CEBPA mRNA] which results in decreased expression of HMGCR mRNA] which results in decreased chemical synthesis of Cholesterol		 CTD PMID:23063590 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Dct dopachrome tautomerase decreases expression ISO artemisic acid results in decreased expression of DCT mRNA CTD PMID:23063590 NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
decreases expression		 ISO [[artemisic acid results in decreased expression of CEBPA mRNA] which results in decreased expression of HMGCR mRNA] which results in decreased chemical synthesis of Cholesterol; [artemisic acid results in decreased expression of HMGCR protein] which results in decreased chemical synthesis of Cholesterol
[artemisic acid results in decreased expression of CEBPA mRNA] which results in decreased expression of HMGCR mRNA; artemisic acid results in decreased expression of HMGCR mRNA; artemisic acid results in decreased expression of HMGCR protein		 CTD PMID:23063590 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression ISO artemisic acid results in decreased expression of KIT mRNA CTD PMID:23063590 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Kitlg KIT ligand decreases expression ISO artemisic acid results in decreased expression of KITLG mRNA CTD PMID:23063590 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214 		JBrowse link
G Mif macrophage migration inhibitory factor decreases expression ISO artemisic acid results in decreased expression of MIF mRNA CTD PMID:23063590 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 		JBrowse link
G Mitf melanocyte inducing transcription factor decreases expression ISO artemisic acid results in decreased expression of MITF mRNA CTD PMID:23063590 NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145 		JBrowse link
G Tyr tyrosinase decreases expression ISO artemisic acid results in decreased expression of TYR mRNA CTD PMID:23063590 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 decreases expression ISO artemisic acid results in decreased expression of TYRP1 mRNA CTD PMID:23063590 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516 		JBrowse link
drimenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO drimenol results in increased expression of BAX protein CTD PMID:30935903 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO drimenol results in decreased expression of BCL2 protein CTD PMID:30935903 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases activity ISO drimenol results in increased activity of CASP3 protein CTD PMID:30935903 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO drimenol results in increased cleavage of CASP9 protein CTD PMID:30935903 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    chemical entity 19920
      molecular entity 19920
        polyatomic entity 19877
          molecule 19770
            cyclic compound 19535
              bicyclic compound 17317
                carbobicyclic compound 5899
                  octahydronaphthalenes 13
                    (+)-5-epi-aristolochene + 0
                    (+)-O-methylkolavelool 0
                    (+)-Tau-muurolol 0
                    (+)-artemisinic acid 9
                    (+)-artemisinic alcohol + 9
                    (+)-delta-cadinol 0
                    (+)-epicubenol 0
                    (+)-eremophilene 0
                    (+)-gamma-cadinene + 0
                    (+)-kolavelool + 0
                    (+)-kolavenyl diphosphate 0
                    (+)-subersic acid 0
                    (-)-4-epi-eremophilene + 0
                    (-)-5-epi-eremophilene 0
                    (-)-7-epi-alpha-selinene 0
                    (-)-Tau-muurolol 0
                    (-)-cubenol 0
                    (-)-delta-cadinol 0
                    (-)-epicubenol 0
                    (-)-eremophilene 0
                    (-)-gamma-cadinene + 0
                    (-)-kolavenyl diphosphate 0
                    (11R)-dihydroartemisinic aldehyde 0
                    (13E)-labda-7,13-dien-15-ol 0
                    (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene 0
                    1-epi-bicyclosesquiphellandrene 0
                    14-hydroxy-6,12-muuroloadien-15-oic acid 0
                    2beta-hydroxy-5-epi-aristolochene 0
                    5-epi-alpha-selinene 0
                    6-isopropenyl-4,4a-dimethyl-2,3,4,4a,5,6,7,8-octahydronaphthalen-2-ol + 0
                    7-epi-alpha-eudesmol 0
                    8-epi-ilicicolin H 0
                    UCS1025 A 0
                    achilleol B 0
                    alpha,gamma-onoceradienediol 0
                    alpha-cadinol 0
                    alpha-eudesmol 0
                    alpha-seco-amyrin 0
                    alpha-selinene 0
                    amorpha-4,11-diene 0
                    aristolochene + 0
                    artemisinic aldehyde + 0
                    ballodiolic acid 0
                    ballotenic acid 0
                    beta-seco-amyrin 0
                    bicyclosesquiphellandrene 0
                    callicarpenal 0
                    capsidiol + 0
                    capsidiol 3-acetate 0
                    dihydroartemisinic acid 0
                    dihydromonacolin L + 0
                    dihydromonacolin L acid + 0
                    dihydrostemphyloxin I 0
                    drimendiol 0
                    drimenol + 4
                    drimenol diphosphate(3-) 0
                    drimenol phosphate(2-) 0
                    dysidine 0
                    elisabethatriene 0
                    equisetin 0
                    gamma-cadinene + 0
                    gamma-muurolene 0
                    hedychilactone D 0
                    ilicicolin H + 0
                    lamesticumin C 0
                    lamesticumin D 0
                    lobophytumin D 0
                    melemeleone B 0
                    mitchellene D 0
                    mitchellene E 0
                    oplodiol 0
                    sch 210971 0
                    sch 210972 + 0
                    sch 213766 0
                    scutebarbatine C 0
                    sibirene + 0
                    solanapyrone A + 0
                    solanapyrone B 0
                    solanapyrone C 0
                    solanapyrone D 0
                    solanapyrone E 0
                    stemphyloxin I + 0
                    talaroconvolutin A 0
                    tau-cadinol 0
                    terpentecin 0
                    terpentedienyl diphosphate 0
                    terpentetriene + 0
                    trichosetin + 0
                    valerianol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon group molecular entity 19805
                          organic molecular entity 19775
                            organic molecule 19755
                              organic cyclic compound 19545
                                carbocyclic compound 18619
                                  carbopolycyclic compound 17189
                                    carbobicyclic compound 5899
                                      octahydronaphthalenes 13
                                        (+)-5-epi-aristolochene + 0
                                        (+)-O-methylkolavelool 0
                                        (+)-Tau-muurolol 0
                                        (+)-artemisinic acid 9
                                        (+)-artemisinic alcohol + 9
                                        (+)-delta-cadinol 0
                                        (+)-epicubenol 0
                                        (+)-eremophilene 0
                                        (+)-gamma-cadinene + 0
                                        (+)-kolavelool + 0
                                        (+)-kolavenyl diphosphate 0
                                        (+)-subersic acid 0
                                        (-)-4-epi-eremophilene + 0
                                        (-)-5-epi-eremophilene 0
                                        (-)-7-epi-alpha-selinene 0
                                        (-)-Tau-muurolol 0
                                        (-)-cubenol 0
                                        (-)-delta-cadinol 0
                                        (-)-epicubenol 0
                                        (-)-eremophilene 0
                                        (-)-gamma-cadinene + 0
                                        (-)-kolavenyl diphosphate 0
                                        (11R)-dihydroartemisinic aldehyde 0
                                        (13E)-labda-7,13-dien-15-ol 0
                                        (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene 0
                                        1-epi-bicyclosesquiphellandrene 0
                                        14-hydroxy-6,12-muuroloadien-15-oic acid 0
                                        2beta-hydroxy-5-epi-aristolochene 0
                                        5-epi-alpha-selinene 0
                                        6-isopropenyl-4,4a-dimethyl-2,3,4,4a,5,6,7,8-octahydronaphthalen-2-ol + 0
                                        7-epi-alpha-eudesmol 0
                                        8-epi-ilicicolin H 0
                                        UCS1025 A 0
                                        achilleol B 0
                                        alpha,gamma-onoceradienediol 0
                                        alpha-cadinol 0
                                        alpha-eudesmol 0
                                        alpha-seco-amyrin 0
                                        alpha-selinene 0
                                        amorpha-4,11-diene 0
                                        aristolochene + 0
                                        artemisinic aldehyde + 0
                                        ballodiolic acid 0
                                        ballotenic acid 0
                                        beta-seco-amyrin 0
                                        bicyclosesquiphellandrene 0
                                        callicarpenal 0
                                        capsidiol + 0
                                        capsidiol 3-acetate 0
                                        dihydroartemisinic acid 0
                                        dihydromonacolin L + 0
                                        dihydromonacolin L acid + 0
                                        dihydrostemphyloxin I 0
                                        drimendiol 0
                                        drimenol + 4
                                        drimenol diphosphate(3-) 0
                                        drimenol phosphate(2-) 0
                                        dysidine 0
                                        elisabethatriene 0
                                        equisetin 0
                                        gamma-cadinene + 0
                                        gamma-muurolene 0
                                        hedychilactone D 0
                                        ilicicolin H + 0
                                        lamesticumin C 0
                                        lamesticumin D 0
                                        lobophytumin D 0
                                        melemeleone B 0
                                        mitchellene D 0
                                        mitchellene E 0
                                        oplodiol 0
                                        sch 210971 0
                                        sch 210972 + 0
                                        sch 213766 0
                                        scutebarbatine C 0
                                        sibirene + 0
                                        solanapyrone A + 0
                                        solanapyrone B 0
                                        solanapyrone C 0
                                        solanapyrone D 0
                                        solanapyrone E 0
                                        stemphyloxin I + 0
                                        talaroconvolutin A 0
                                        tau-cadinol 0
                                        terpentecin 0
                                        terpentedienyl diphosphate 0
                                        terpentetriene + 0
                                        trichosetin + 0
                                        valerianol 0
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