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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carotenoid biosynthesis inhibitor
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Accession:CHEBI:138208 term browser browse the term
Definition:Any pathway inhibitor that acts on the carotenoid biosynthesis pathway.
Synonyms:related_synonym: carotenogenesis inhibitor;   carotenogenesis inhibitors;   carotenoid-biosynthesis inhibitors


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aclonifen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO aclonifen results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
amitrole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 multiple interactions ISO ABCB6 inhibits the reaction [[Amitrole results in decreased activity of CAT protein] which results in increased susceptibility to sodium arsenite]; Amitrole inhibits the reaction [ABCB6 protein results in increased activity of CAT protein] CTD PMID:21266531 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of ACE protein] CTD PMID:25891026 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Agt angiotensinogen multiple interactions EXP Amitrole promotes the reaction [AGT protein results in increased degradation of NFKBIA protein] CTD PMID:10712386 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G App amyloid beta precursor protein affects activity EXP Amitrole affects the activity of APP protein CTD PMID:16204253 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Amitrole results in increased activity of CASP3 protein
Amitrole inhibits the reaction [Cadmium results in increased degradation of CASP3 protein]
CTD PMID:12538343, PMID:20417273 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
decreases activity
affects activity
affects binding
ISO
EXP
[Amitrole results in decreased activity of CAT protein] which results in increased expression of VEGFA mRNA; [Amitrole results in decreased activity of CAT protein] which results in increased susceptibility to Hydrogen Peroxide; [Amitrole results in decreased activity of CAT protein] which results in increased susceptibility to sodium arsenite; ABCB6 inhibits the reaction [[Amitrole results in decreased activity of CAT protein] which results in increased susceptibility to sodium arsenite]; Amitrole inhibits the reaction [ABCB6 protein results in increased activity of CAT protein]
[Amitrole results in decreased activity of CAT protein] which results in decreased susceptibility to BMS 191095; Amitrole affects the reaction [[lead acetate results in increased abundance of Lead] affects the reaction [Ethanol affects the expression of CAT protein]]; Amitrole affects the reaction [[lead acetate results in increased abundance of Lead] which affects the expression of CAT protein]; Amitrole affects the reaction [Ethanol affects the expression of CAT protein]; Amitrole inhibits the reaction [pirinixic acid results in increased activity of CAT protein]
Amitrole affects the activity of CAT protein
Amitrole binds to CAT protein
CTD PMID:8947833, PMID:9569045, PMID:9635878, PMID:10382262, PMID:10468195, PMID:10961904, PMID:12423650, PMID:12427601, PMID:12621067, PMID:15234257, PMID:15935206, PMID:16204253, PMID:16407272, PMID:17597214, PMID:18212794, PMID:18234233, PMID:18930813, PMID:21266531, PMID:24717679, PMID:31550440 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Amitrole results in decreased expression of CCL2 mRNA CTD PMID:23397585 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of CYBB protein] CTD PMID:25891026 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases activity
multiple interactions
increases expression
ISO Amitrole results in increased activity of CYP2A5 protein
heme arginate inhibits the reaction [Amitrole results in increased activity of CYP2A5 protein]
Amitrole results in increased expression of CYP2A5 mRNA; Amitrole results in increased expression of CYP2A5 protein
CTD PMID:7543189, PMID:9698299 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP Amitrole inhibits the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA] CTD PMID:11353799, PMID:14722249 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Amitrole results in decreased activity of CYP2E1 protein CTD PMID:12464242 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Endog endonuclease G decreases activity EXP Amitrole results in decreased activity of ENDOG protein CTD PMID:16407272 NCBI chr 3:8,741,833...8,744,414
Ensembl chr 3:8,741,766...8,744,592
JBrowse link
G Epo erythropoietin multiple interactions ISO [Amitrole results in increased abundance of Hydrogen Peroxide] which results in decreased expression of EPO protein CTD PMID:7980410 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in decreased expression of GAD1 protein] CTD PMID:25891026 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions EXP Amitrole inhibits the reaction [cobaltous chloride results in increased expression of GSTA1 mRNA]; Amitrole inhibits the reaction [cobaltous chloride results in increased expression of GSTA1 protein] CTD PMID:25820916 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gulp1 GULP PTB domain containing engulfment adaptor 1 increases expression ISO Amitrole results in increased expression of GULP1 mRNA CTD PMID:23397585 NCBI chr 9:51,263,484...51,538,066
Ensembl chr 9:51,263,622...51,538,072
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Amitrole inhibits the reaction [cobaltous chloride results in increased expression of HMOX1 mRNA]; Amitrole inhibits the reaction [cobaltous chloride results in increased expression of HMOX1 protein] CTD PMID:25820916 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO Amitrole results in decreased expression of ID2 mRNA CTD PMID:23397585 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein decreases expression ISO Amitrole results in decreased expression of ID3 mRNA CTD PMID:23397585 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Il10 interleukin 10 multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in decreased expression of IL10 protein] CTD PMID:25891026 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of IL1B protein] CTD PMID:25891026 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Amitrole inhibits the reaction [cobaltous chloride results in increased expression of IL6 protein] CTD PMID:25820916 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgb5 integrin subunit beta 5 decreases expression ISO Amitrole results in decreased expression of ITGB5 mRNA CTD PMID:23397585 NCBI chr11:70,056,500...70,172,164
Ensembl chr11:70,056,500...70,172,372
JBrowse link
G Klf9 Kruppel-like factor 9 decreases expression ISO Amitrole results in decreased expression of KLF9 mRNA CTD PMID:23397585 NCBI chr 1:240,908,483...240,933,198
Ensembl chr 1:240,908,483...240,933,198
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha multiple interactions ISO Amitrole inhibits the reaction [dihydrocapsaicin results in increased expression of MAP1LC3A protein] CTD PMID:18818525 NCBI chr 3:150,801,289...150,802,935
Ensembl chr 3:150,801,289...150,802,935
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO [Amitrole co-treated with SOD2 protein] results in increased expression of MMP1 mRNA; Deferoxamine inhibits the reaction [[Amitrole co-treated with SOD2 protein] results in increased expression of MMP1 mRNA] CTD PMID:10464329 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Amitrole inhibits the reaction [fluvastatin results in decreased expression of MMP2 mRNA] CTD PMID:24964743 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Amitrole inhibits the reaction [fluvastatin results in decreased expression of MMP9 mRNA] CTD PMID:24964743 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming decreases expression ISO Amitrole results in decreased expression of MUC5AC mRNA CTD PMID:17512462 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Amitrole promotes the reaction [AGT protein results in increased degradation of NFKBIA protein] CTD PMID:10712386 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngf nerve growth factor affects activity EXP Amitrole affects the activity of NGF protein CTD PMID:15935206 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of NOX4 protein] CTD PMID:25891026 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [Amitrole co-treated with SOD2 protein] results in increased expression of MMP1 mRNA; Deferoxamine inhibits the reaction [[Amitrole co-treated with SOD2 protein] results in increased expression of MMP1 mRNA] CTD PMID:10464329 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tbx3 T-box transcription factor 3 decreases expression ISO Amitrole results in decreased expression of TBX3 mRNA CTD PMID:23397585 NCBI chr12:42,479,518...42,494,588
Ensembl chr12:42,480,560...42,492,526
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO Amitrole inhibits the reaction [fluvastatin results in decreased expression of TFRC protein] CTD PMID:24964743 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tg thyroglobulin increases expression
decreases secretion
EXP Amitrole results in increased expression of TG mRNA
Amitrole results in decreased secretion of TG protein
CTD PMID:20937625 NCBI chr 7:107,467,260...107,652,897
Ensembl chr 7:107,467,260...107,652,899
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of TH protein] CTD PMID:25891026 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tnf tumor necrosis factor decreases response to substance
multiple interactions
EXP
ISO
Amitrole results in decreased susceptibility to TNF protein
Amitrole inhibits the reaction [cobaltous chloride results in increased expression of TNF protein]
CTD PMID:12775721, PMID:25820916 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tpo thyroid peroxidase decreases activity EXP
ISO
Amitrole results in decreased activity of TPO protein CTD PMID:20937625, PMID:31629072 NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [Amitrole results in decreased activity of CAT protein] which results in increased expression of VEGFA mRNA CTD PMID:18930813 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
Fluridone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO fluridone inhibits the reaction [CCL2 protein results in increased secretion of Abscisic Acid]; fluridone inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]
fluridone inhibits the reaction [Zymosan results in increased expression of CCL2 protein]
CTD PMID:24211328 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO fluridone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; fluridone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:24211328 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
nitisinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLC mRNA CTD PMID:12899938 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLM mRNA CTD PMID:12899938 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [nitisinone results in decreased activity of HPD protein] which results in decreased expression of HMOX1 mRNA CTD PMID:12899938 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hpd 4-hydroxyphenylpyruvate dioxygenase multiple interactions ISO [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLC mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLM mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of HMOX1 mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of NQO1 mRNA CTD PMID:12899938 NCBI chr12:38,828,606...38,839,956
Ensembl chr12:38,828,444...38,839,969
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [nitisinone results in decreased activity of HPD protein] which results in decreased expression of NQO1 mRNA CTD PMID:12899938 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
norflurazon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]; [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to norflurazone CTD PMID:16608219 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]; [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to norflurazone; CYP2B6 protein results in increased metabolism of and results in decreased susceptibility to norflurazone CTD PMID:15853388, PMID:16608219 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]; [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to norflurazone CTD PMID:16608219 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      biological role 19737
        biochemical role 19241
          enzyme inhibitor 18163
            pathway inhibitor 8734
              carotenoid biosynthesis inhibitor 49
                Benzofenap 0
                Fluridone 2
                aclonifen 1
                amitrole 40
                beflubutamid 0
                benzobicyclon 0
                benzobicyclon hydrolysate 0
                bicyclopyrone 0
                bixlozone 0
                clomazone 0
                destosyl pyrazolate 0
                diflufenican 0
                flurochloridone 0
                flurtamone 0
                mesotrione + 5
                norflurazon 3
                picolinafen 0
                pyrasulfotole 0
                pyrazolynate 0
                pyrazoxyfen 0
                sulcotrione 0
                tefuryltrione 0
                tembotrione 0
                topramezone 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.