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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carotenoid biosynthesis inhibitor
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Accession:CHEBI:138208 term browser browse the term
Definition:Any pathway inhibitor that acts on the carotenoid biosynthesis pathway.
Synonyms:related_synonym: carotenogenesis inhibitor;   carotenogenesis inhibitors;   carotenoid-biosynthesis inhibitors



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aclonifen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO aclonifen results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
amitrole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 multiple interactions ISO ABCB6 inhibits the reaction [[Amitrole results in decreased activity of CAT protein] which results in increased susceptibility to sodium arsenite]; Amitrole inhibits the reaction [ABCB6 protein results in increased activity of CAT protein] CTD PMID:21266531 NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of ACE protein] CTD PMID:25891026 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Agt angiotensinogen multiple interactions EXP Amitrole promotes the reaction [AGT protein results in increased degradation of NFKBIA protein] CTD PMID:10712386 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G App amyloid beta precursor protein affects activity EXP Amitrole affects the activity of APP protein CTD PMID:16204253 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Amitrole results in increased activity of CASP3 protein
Amitrole inhibits the reaction [Cadmium results in increased degradation of CASP3 protein]
CTD PMID:12538343 PMID:20417273 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions
decreases activity
affects activity
affects binding
ISO
EXP
[Amitrole results in decreased activity of CAT protein] which results in increased abundance of Hydrogen Peroxide; [Amitrole results in decreased activity of CAT protein] which results in increased expression of VEGFA mRNA; [Amitrole results in decreased activity of CAT protein] which results in increased susceptibility to Hydrogen Peroxide; [Amitrole results in decreased activity of CAT protein] which results in increased susceptibility to sodium arsenite; ABCB6 inhibits the reaction [[Amitrole results in decreased activity of CAT protein] which results in increased susceptibility to sodium arsenite]; Amitrole inhibits the reaction [ABCB6 protein results in increased activity of CAT protein]
[Amitrole results in decreased activity of CAT protein] which results in decreased susceptibility to BMS 191095; Amitrole affects the reaction [[lead acetate results in increased abundance of Lead] affects the reaction [Ethanol affects the expression of CAT protein]]; Amitrole affects the reaction [[lead acetate results in increased abundance of Lead] which affects the expression of CAT protein]; Amitrole affects the reaction [Ethanol affects the expression of CAT protein]; Amitrole inhibits the reaction [pirinixic acid results in increased activity of CAT protein]
Amitrole affects the activity of CAT protein
Amitrole binds to CAT protein
CTD PMID:8947833 PMID:9569045 PMID:9635878 PMID:10382262 PMID:10468195 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Amitrole results in decreased expression of CCL2 mRNA CTD PMID:23397585 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of CYBB protein] CTD PMID:25891026 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases activity
multiple interactions
increases expression
ISO Amitrole results in increased activity of CYP2A5 protein
heme arginate inhibits the reaction [Amitrole results in increased activity of CYP2A5 protein]
Amitrole results in increased expression of CYP2A5 mRNA; Amitrole results in increased expression of CYP2A5 protein
CTD PMID:7543189 PMID:9698299 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP Amitrole inhibits the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA] CTD PMID:11353799 PMID:14722249 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Amitrole results in decreased activity of CYP2E1 protein CTD PMID:12464242 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Endog endonuclease G decreases activity EXP Amitrole results in decreased activity of ENDOG protein CTD PMID:16407272 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
JBrowse link
G Epo erythropoietin multiple interactions ISO [Amitrole results in increased abundance of Hydrogen Peroxide] which results in decreased expression of EPO protein CTD PMID:7980410 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in decreased expression of GAD1 protein] CTD PMID:25891026 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions EXP Amitrole inhibits the reaction [cobaltous chloride results in increased expression of GSTA1 mRNA]; Amitrole inhibits the reaction [cobaltous chloride results in increased expression of GSTA1 protein] CTD PMID:25820916 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gulp1 GULP PTB domain containing engulfment adaptor 1 increases expression ISO Amitrole results in increased expression of GULP1 mRNA CTD PMID:23397585 NCBI chr 9:46,622,699...46,899,005
Ensembl chr 9:46,622,669...46,899,005
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Amitrole inhibits the reaction [cobaltous chloride results in increased expression of HMOX1 mRNA]; Amitrole inhibits the reaction [cobaltous chloride results in increased expression of HMOX1 protein] CTD PMID:25820916 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO Amitrole results in decreased expression of ID2 mRNA CTD PMID:23397585 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein decreases expression ISO Amitrole results in decreased expression of ID3 mRNA CTD PMID:23397585 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
JBrowse link
G Il10 interleukin 10 multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in decreased expression of IL10 protein] CTD PMID:25891026 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of IL1B protein] CTD PMID:25891026 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Amitrole inhibits the reaction [cobaltous chloride results in increased expression of IL6 protein] CTD PMID:25820916 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgb5 integrin subunit beta 5 decreases expression ISO Amitrole results in decreased expression of ITGB5 mRNA CTD PMID:23397585 NCBI chr11:66,828,428...66,944,231
Ensembl chr11:66,829,285...66,944,472
JBrowse link
G Klf9 Kruppel-like factor 9 decreases expression ISO Amitrole results in decreased expression of KLF9 mRNA CTD PMID:23397585 NCBI chr 1:220,700,108...220,725,029
Ensembl chr 1:220,700,108...220,725,037
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha multiple interactions ISO Amitrole inhibits the reaction [dihydrocapsaicin results in increased expression of MAP1LC3A protein] CTD PMID:18818525 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO [Amitrole co-treated with SOD2 protein] results in increased expression of MMP1 mRNA; Deferoxamine inhibits the reaction [[Amitrole co-treated with SOD2 protein] results in increased expression of MMP1 mRNA] CTD PMID:10464329 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Amitrole inhibits the reaction [fluvastatin results in decreased expression of MMP2 mRNA] CTD PMID:24964743 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Amitrole inhibits the reaction [fluvastatin results in decreased expression of MMP9 mRNA] CTD PMID:24964743 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming decreases expression ISO Amitrole results in decreased expression of MUC5AC mRNA CTD PMID:17512462 NCBI chr 1:196,864,375...196,896,475 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Amitrole promotes the reaction [AGT protein results in increased degradation of NFKBIA protein] CTD PMID:10712386 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ngf nerve growth factor affects activity EXP Amitrole affects the activity of NGF protein CTD PMID:15935206 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of NOX4 protein] CTD PMID:25891026 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [Amitrole co-treated with SOD2 protein] results in increased expression of MMP1 mRNA; Deferoxamine inhibits the reaction [[Amitrole co-treated with SOD2 protein] results in increased expression of MMP1 mRNA] CTD PMID:10464329 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tbx3 T-box transcription factor 3 decreases expression ISO Amitrole results in decreased expression of TBX3 mRNA CTD PMID:23397585 NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO Amitrole inhibits the reaction [fluvastatin results in decreased expression of TFRC protein] CTD PMID:24964743 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tg thyroglobulin increases expression
decreases secretion
EXP Amitrole results in increased expression of TG mRNA
Amitrole results in decreased secretion of TG protein
CTD PMID:20937625 NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of TH protein] CTD PMID:25891026 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tnf tumor necrosis factor decreases response to substance
multiple interactions
EXP
ISO
Amitrole results in decreased susceptibility to TNF protein
Amitrole inhibits the reaction [cobaltous chloride results in increased expression of TNF protein]
CTD PMID:12775721 PMID:25820916 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tpo thyroid peroxidase decreases activity EXP
ISO
Amitrole results in decreased activity of TPO protein CTD PMID:20937625 PMID:31629072 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [Amitrole results in decreased activity of CAT protein] which results in increased expression of VEGFA mRNA CTD PMID:18930813 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
Fluridone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO fluridone inhibits the reaction [CCL2 protein results in increased secretion of Abscisic Acid]; fluridone inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]
fluridone inhibits the reaction [Zymosan results in increased expression of CCL2 protein]
CTD PMID:24211328 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO fluridone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; fluridone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:24211328 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
nitisinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLC mRNA CTD PMID:12899938 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLM mRNA CTD PMID:12899938 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [nitisinone results in decreased activity of HPD protein] which results in decreased expression of HMOX1 mRNA CTD PMID:12899938 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hpd 4-hydroxyphenylpyruvate dioxygenase multiple interactions ISO [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLC mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLM mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of HMOX1 mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of NQO1 mRNA CTD PMID:12899938 NCBI chr12:33,381,397...33,392,750
Ensembl chr12:33,381,231...33,392,766
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [nitisinone results in decreased activity of HPD protein] which results in decreased expression of NQO1 mRNA CTD PMID:12899938 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
norflurazon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]; [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to norflurazone CTD PMID:16608219 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]; [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to norflurazone; CYP2B6 protein results in increased metabolism of and results in decreased susceptibility to norflurazone CTD PMID:15853388 PMID:16608219 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]; [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to norflurazone CTD PMID:16608219 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        biochemical role 19368
          enzyme inhibitor 18380
            pathway inhibitor 9645
              carotenoid biosynthesis inhibitor 49
                Benzofenap 0
                Fluridone 2
                aclonifen 1
                amitrole 40
                beflubutamid 0
                benzobicyclon 0
                benzobicyclon hydrolysate 0
                bicyclopyrone 0
                bixlozone 0
                clomazone 0
                destosyl pyrazolate 0
                diflufenican 0
                flurochloridone 0
                flurtamone 0
                mesotrione + 5
                norflurazon 3
                picolinafen 0
                pyrasulfotole 0
                pyrazolynate 0
                pyrazoxyfen 0
                sulcotrione 0
                tefuryltrione 0
                tembotrione 0
                topramezone 0
paths to the root