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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:perfluorooctanesulfonamide
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Accession:CHEBI:138089 term browser browse the term
Definition:A perfluorinated compound that is perfluorooctane in which one of the terminal fluorines has been replace by a sulfamoyl group.
Synonyms:exact_synonym: 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonamide
 related_synonym: Formula=C8H2F17NO2S;   InChI=1S/C8H2F17NO2S/c9-1(10,3(13,14)5(17,18)7(21,22)23)2(11,12)4(15,16)6(19,20)8(24,25)29(26,27)28/h(H2,26,27,28);   InChIKey=RRRXPPIDPYTNJG-UHFFFAOYSA-N;   PFOSA;   SMILES=C(C(C(C(C(C(C(C(S(N)(=O)=O)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)(F)F;   heptadecafluorooctanesulphonamide;   perfluoroctylsulfonamide;   perfluorooctane sulfonamide;   perfluorooctanesulfonic acid amide
 xref: CAS:754-91-6
 xref_mesh: MESH:C063900
 xref: PMID:16720684;   PMID:16786681;   PMID:17295423;   PMID:17384769;   PMID:18007991;   PMID:20951402;   PMID:25222623;   PMID:26053759;   PMID:27239709;   PMID:27276029;   PMID:28092384;   PMID:28350446;   Reaxys:1813858;   Wikipedia:Perfluorooctanesulfonamide



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perfluorooctanesulfonamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa1a acetyl-CoA acyltransferase 1A multiple interactions EXP [perfluorooctanesulfonamide results in increased activity of PPARA protein] which results in increased expression of ACAA1A mRNA; [perfluorooctanesulfonamide results in increased activity of PPARA protein] which results in increased expression of ACAA1A protein CTD PMID:15071170 NCBI chr 8:119,079,401...119,088,624
Ensembl chr 8:119,079,775...119,088,624
JBrowse link
G Cdh5 cadherin 5 affects expression ISO perfluorooctanesulfonamide affects the expression of CDH5 protein CTD PMID:33677611 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase multiple interactions EXP [perfluorooctanesulfonamide results in increased activity of PPARA protein] which results in increased expression of EHHADH mRNA CTD PMID:15071170 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
JBrowse link
G Itga1 integrin subunit alpha 1 affects expression ISO perfluorooctanesulfonamide affects the expression of ITGA1 protein CTD PMID:33677611 NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238
JBrowse link
G Mmp1 matrix metallopeptidase 1 affects expression ISO perfluorooctanesulfonamide affects the expression of MMP1 protein CTD PMID:33677611 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity
decreases activity
multiple interactions
ISO
EXP
perfluorooctanesulfonamide results in increased activity of PPARA protein
perfluorooctanesulfonamide results in decreased activity of PPARA protein
[perfluorooctanesulfonamide results in increased activity of PPARA protein] which results in increased expression of ACAA1A mRNA; [perfluorooctanesulfonamide results in increased activity of PPARA protein] which results in increased expression of ACAA1A protein; [perfluorooctanesulfonamide results in increased activity of PPARA protein] which results in increased expression of EHHADH mRNA
CTD PMID:15071170 PMID:28857218 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      chemical role 19539
        environmental contaminant 18812
          persistent organic pollutant 16532
            perfluorooctanesulfonamide 6
              perfluorooctane sulfonamidoacetic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      chalcogen 19683
                        oxygen atom 19655
                          oxygen molecular entity 19655
                            hydroxides 19380
                              oxoacid 18684
                                chalcogen oxoacid 11677
                                  sulfur oxoacid 11296
                                    sulfonic acid 7650
                                      sulfonic acid derivative 7650
                                        sulfonamide 3204
                                          perfluorooctanesulfonamide 6
                                            perfluorooctane sulfonamidoacetic acid 0
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