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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:perfluorooctanesulfonamide
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Accession:CHEBI:138089 term browser browse the term
Definition:A perfluorinated compound that is perfluorooctane in which one of the terminal fluorines has been replace by a sulfamoyl group.
Synonyms:exact_synonym: 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonamide
 related_synonym: Formula=C8H2F17NO2S;   InChI=1S/C8H2F17NO2S/c9-1(10,3(13,14)5(17,18)7(21,22)23)2(11,12)4(15,16)6(19,20)8(24,25)29(26,27)28/h(H2,26,27,28);   InChIKey=RRRXPPIDPYTNJG-UHFFFAOYSA-N;   PFOSA;   SMILES=C(C(C(C(C(C(C(C(S(N)(=O)=O)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)(F)F;   heptadecafluorooctanesulphonamide;   perfluoroctylsulfonamide;   perfluorooctane sulfonamide;   perfluorooctanesulfonic acid amide
 xref: CAS:754-91-6
 xref_mesh: MESH:C063900
 xref: PMID:16720684;   PMID:16786681;   PMID:17295423;   PMID:17384769;   PMID:18007991;   PMID:20951402;   PMID:25222623;   PMID:26053759;   PMID:27239709;   PMID:27276029;   PMID:28092384;   PMID:28350446;   Reaxys:1813858;   Wikipedia:Perfluorooctanesulfonamide


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perfluorooctanesulfonamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa1a acetyl-CoA acyltransferase 1A multiple interactions EXP [perfluorooctanesulfonamide results in increased activity of PPARA protein] which results in increased expression of ACAA1A mRNA; [perfluorooctanesulfonamide results in increased activity of PPARA protein] which results in increased expression of ACAA1A protein CTD PMID:15071170 NCBI chr 8:128,027,880...128,036,471
Ensembl chr 8:128,027,958...128,036,236
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase multiple interactions EXP [perfluorooctanesulfonamide results in increased activity of PPARA protein] which results in increased expression of EHHADH mRNA CTD PMID:15071170 NCBI chr11:82,945,104...82,978,364
Ensembl chr11:82,945,104...82,978,364
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity
decreases activity
multiple interactions
ISO
EXP
perfluorooctanesulfonamide results in increased activity of PPARA protein
perfluorooctanesulfonamide results in decreased activity of PPARA protein
[perfluorooctanesulfonamide results in increased activity of PPARA protein] which results in increased expression of ACAA1A mRNA; [perfluorooctanesulfonamide results in increased activity of PPARA protein] which results in increased expression of ACAA1A protein; [perfluorooctanesulfonamide results in increased activity of PPARA protein] which results in increased expression of EHHADH mRNA
CTD PMID:15071170 PMID:28857218 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    role 19804
      chemical role 19320
        environmental contaminant 18645
          persistent organic pollutant 15811
            perfluorooctanesulfonamide 3
              perfluorooctane sulfonamidoacetic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      chalcogen 19438
                        oxygen atom 19400
                          oxygen molecular entity 19400
                            hydroxides 19123
                              oxoacid 18256
                                chalcogen oxoacid 11493
                                  sulfur oxoacid 11097
                                    sulfonic acid 7345
                                      sulfonic acid derivative 7345
                                        sulfonamide 3178
                                          perfluorooctanesulfonamide 3
                                            perfluorooctane sulfonamidoacetic acid 0
paths to the root