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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:14alpha-methyl steroid
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Accession:CHEBI:138029 term browser browse the term
Definition:Any steroid carrying a 14alpha-methyl substituent.
Synonyms:related_synonym: Formula=C20H33R;   SMILES=C12C([C@]3(C(C(CC3)*)(C)CC1)C)CCC4C2(CCCC4)C;   a 14alpha-methyl steroid
 xref: MetaCyc:14-alpha-methylsteroids


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14-demethyllanosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Msmo1 methylsterol monoxygenase 1 decreases abundance ISO MSMO1 protein results in decreased abundance of 4,4-dimethyl-5-alpha-cholesta-(8,24)-dien-3-beta-ol CTD PMID:23125191 NCBI chr 8:65,171,157...65,186,822
Ensembl chr 8:65,171,173...65,186,826 		JBrowse link
24,25-dihydrolanosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp51 cytochrome P450, family 51 decreases abundance ISO CYP51A1 mRNA results in decreased abundance of lanostenol CTD PMID:23125191 NCBI chr 5:4,130,674...4,154,697
Ensembl chr 5:4,131,145...4,154,746 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase decreases activity ISO lanostenol results in decreased activity of HMGCR protein CTD PMID:18024962 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444 		JBrowse link
lanosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases metabolic processing ISO CYP27A1 protein results in increased metabolism of Lanosterol CTD PMID:14622972 NCBI chr 1:74,752,311...74,777,056
Ensembl chr 1:74,752,733...74,777,051 		JBrowse link
G Cyp51 cytochrome P450, family 51 multiple interactions ISO [Ketoconazole results in increased activity of CYP51 protein] which results in increased abundance of Lanosterol
CYP51A1 gene inhibits the reaction [Fluconazole results in decreased metabolism of and results in increased abundance of Lanosterol]; CYP51A1 gene inhibits the reaction [Itraconazole results in decreased metabolism of and results in increased abundance of Lanosterol]; CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased metabolism of and results in increased abundance of Lanosterol]; CYP51A1 gene inhibits the reaction [Voriconazole results in decreased metabolism of and results in increased abundance of Lanosterol]		 CTD PMID:12617470 PMID:18694951 NCBI chr 5:4,130,674...4,154,697
Ensembl chr 5:4,131,145...4,154,746 		JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal multiple interactions EXP Lanosterol analog inhibits the reaction [EPHX1 protein results in increased metabolism of cholesterol alpha-oxide] CTD PMID:2043152 NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469 		JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic multiple interactions EXP Lanosterol analog inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog] CTD PMID:2043152 NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949 		JBrowse link
G Marchf6 membrane associated ring-CH-type finger 6 increases stability ISO Lanosterol results in increased stability of MARCHF6 protein CTD PMID:30545937 NCBI chr15:31,456,045...31,531,172
Ensembl chr15:31,456,037...31,531,199 		JBrowse link
G Nr1h5 nuclear receptor subfamily 1, group H, member 5 increases activity EXP Lanosterol results in increased activity of NR1H5 protein CTD PMID:17567710 NCBI chr 3:102,846,974...102,871,607
Ensembl chr 3:102,846,974...102,871,449 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    chemical entity 22208
      atom 22170
        nonmetal atom 22055
          carbon atom 21859
            organic molecular entity 21830
              lipid 18859
                steroid 14869
                  14alpha-methyl steroid 8
                    14alpha-dihydroxymethyl steroid 0
                    14alpha-hydroxymethyl steroid + 0
                    26-hydroxylanosterol 0
                    26-oxolanosterol 0
                    3beta-hydroxy-lanosta-8, 24-dien-26-oate 0
                    eburicol + 0
                    hainanic acid A 0
                    lanosterol + 8
                    obtusifoliol 0
                    pneumocysterol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            organic molecule 21647
                              organic cyclic compound 21252
                                organic polycyclic compound 17940
                                  steroid 14869
                                    14alpha-methyl steroid 8
                                      14alpha-dihydroxymethyl steroid 0
                                      14alpha-hydroxymethyl steroid + 0
                                      26-hydroxylanosterol 0
                                      26-oxolanosterol 0
                                      3beta-hydroxy-lanosta-8, 24-dien-26-oate 0
                                      eburicol + 0
                                      hainanic acid A 0
                                      lanosterol + 8
                                      obtusifoliol 0
                                      pneumocysterol 0
paths to the root