|
G |
Msmo1 |
methylsterol monooxygenase 1 |
decreases abundance |
ISO |
MSMO1 protein results in decreased abundance of 4,4-dimethyl-5-alpha-cholesta-(8,24)-dien-3-beta-ol |
CTD |
PMID:23125191 |
|
NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
|
|
|
G |
Cyp51 |
cytochrome P450, family 51 |
decreases abundance |
ISO |
CYP51A1 mRNA results in decreased abundance of lanostenol |
CTD |
PMID:23125191 |
|
NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
|
|
G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
decreases activity |
ISO |
lanostenol results in decreased activity of HMGCR protein |
CTD |
PMID:18024962 |
|
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
|
|
|
G |
Cyp27a1 |
cytochrome P450, family 27, subfamily a, polypeptide 1 |
increases metabolic processing |
ISO |
CYP27A1 protein results in increased metabolism of Lanosterol |
CTD |
PMID:14622972 |
|
NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
|
|
G |
Cyp51 |
cytochrome P450, family 51 |
multiple interactions |
EXP ISO |
[Ketoconazole results in increased activity of CYP51 protein] which results in increased abundance of Lanosterol CYP51A1 gene inhibits the reaction [Fluconazole results in decreased metabolism of and results in increased abundance of Lanosterol]; CYP51A1 gene inhibits the reaction [Itraconazole results in decreased metabolism of and results in increased abundance of Lanosterol]; CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased metabolism of and results in increased abundance of Lanosterol]; CYP51A1 gene inhibits the reaction [Voriconazole results in decreased metabolism of and results in increased abundance of Lanosterol] |
CTD |
PMID:12617470 PMID:18694951 |
|
NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
|
|
G |
Ephx1 |
epoxide hydrolase 1 |
multiple interactions |
ISO |
Lanosterol analog inhibits the reaction [EPHX1 protein results in increased metabolism of cholesterol alpha-oxide] |
CTD |
PMID:2043152 |
|
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
|
|
G |
Ephx2 |
epoxide hydrolase 2 |
multiple interactions |
ISO |
Lanosterol analog inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog] |
CTD |
PMID:2043152 |
|
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
|
|
G |
Marchf6 |
membrane associated ring-CH-type finger 6 |
increases stability |
ISO |
Lanosterol results in increased stability of MARCHF6 protein |
CTD |
PMID:30545937 |
|
NCBI chr 2:82,455,686...82,532,917
Ensembl chr 2:82,455,689...82,532,910
|
|