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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ilomastat
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Accession:CHEBI:137236 term browser browse the term
Definition:An N-acyl-amino acid obtained by formal condensation of the carboxy group of (2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the amino group of N-methyl-L-tryptophanamide. A cell permeable broad-spectrum matrix metalloproteinase (MMP) inhibitor
Synonyms:exact_synonym: (2R)-N(4)-hydroxy-N(1)-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide
 related_synonym: CS 610;   Formula=C20H28N4O4;   GM 6001;   GM6001;   InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1;   InChIKey=NITYDPDXAAFEIT-DYVFJYSZSA-N;   SMILES=C(C(NO)=O)[C@H](C(N[C@H](C(NC)=O)CC=1C=2C(NC1)=CC=CC2)=O)CC(C)C;   galardin
 alt_id: CHEBI:42919
 xref: CAS:142880-36-2;   KEGG:D03793;   LINCS:LSM-3143
 xref_mesh: MESH:C119203
 xref: PDBeChem:GM6;   PMID:12410973;   PMID:14568001;   PMID:15350544;   PMID:16565079;   PMID:16712832;   PMID:18782669;   PMID:18790756;   PMID:18837084;   PMID:19545667;   PMID:20299089;   PMID:20818082;   PMID:21040999;   PMID:21146503;   PMID:22512086;   PMID:22903888;   PMID:23141517;   PMID:23870824;   PMID:24380772;   PMID:24589605;   PMID:25576979;   PMID:26171681;   PMID:26394037;   PMID:27038494;   PMID:27112177;   PMID:27296149;   PMID:27708133;   PMID:27743382;   PMID:28297575;   PMID:28298987;   PMID:28417261;   Reaxys:7982373;   Wikipedia:Ilomastat


show annotations for term's descendants           Sort by:
ilomastat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL13 interleukin 13 multiple interactions ISO ilomastat inhibits the reaction [Mustard Gas results in increased expression of IL13 protein] CTD PMID:18852015 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110 		JBrowse link
G MMP1 matrix metallopeptidase 1 multiple interactions ISO ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP1 protein]; ilomastat inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP1 mRNA] CTD PMID:18837084 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160 		JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TIMP1 mRNA]; ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TIMP1 protein] CTD PMID:18837084 NCBI chr  X:47,582,436...47,586,789
Ensembl chr  X:47,582,408...47,586,789 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    role 25957
      application 25179
        anti-inflammatory agent 17811
          ilomastat 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    main group molecular entity 25841
                      s-block molecular entity 25162
                        hydrogen molecular entity 24761
                          hydrides 22973
                            inorganic hydride 20500
                              pnictogen hydride 20441
                                nitrogen hydride 20219
                                  azane 19961
                                    ammonia 19960
                                      organic amino compound 19960
                                        amino acid 17174
                                          alpha-amino acid 14705
                                            L-alpha-amino acid 13797
                                              erythrose 4-phosphate/phosphoenolpyruvate family amino acid 2447
                                                L-tryptophan 17
                                                  L-tryptophan derivative 4
                                                    ilomastat 3
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