Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ilomastat
go back to main search page
Accession:CHEBI:137236 term browser browse the term
Definition:An N-acyl-amino acid obtained by formal condensation of the carboxy group of (2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the amino group of N-methyl-L-tryptophanamide. A cell permeable broad-spectrum matrix metalloproteinase (MMP) inhibitor
Synonyms:exact_synonym: (2R)-N(4)-hydroxy-N(1)-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide
 related_synonym: CS 610;   Formula=C20H28N4O4;   GM 6001;   GM6001;   InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1;   InChIKey=NITYDPDXAAFEIT-DYVFJYSZSA-N;   SMILES=C(C(NO)=O)[C@H](C(N[C@H](C(NC)=O)CC=1C=2C(NC1)=CC=CC2)=O)CC(C)C;   galardin
 alt_id: CHEBI:42919
 xref: CAS:142880-36-2;   KEGG:D03793;   LINCS:LSM-3143
 xref_mesh: MESH:C119203
 xref: PDBeChem:GM6;   PMID:12410973;   PMID:14568001;   PMID:15350544;   PMID:16565079;   PMID:16712832;   PMID:18782669;   PMID:18790756;   PMID:18837084;   PMID:19545667;   PMID:20299089;   PMID:20818082;   PMID:21040999;   PMID:21146503;   PMID:22512086;   PMID:22903888;   PMID:23141517;   PMID:23870824;   PMID:24380772;   PMID:24589605;   PMID:25576979;   PMID:26171681;   PMID:26394037;   PMID:27038494;   PMID:27112177;   PMID:27296149;   PMID:27708133;   PMID:27743382;   PMID:28297575;   PMID:28298987;   PMID:28417261;   Reaxys:7982373;   Wikipedia:Ilomastat



show annotations for term's descendants           Sort by:
ilomastat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il13 interleukin 13 multiple interactions EXP ilomastat inhibits the reaction [Mustard Gas results in increased expression of IL13 protein] CTD PMID:18852015 NCBI chr10:38,290,926...38,293,483 JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions EXP ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP1 protein]; ilomastat inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP1 mRNA] CTD PMID:18837084 NCBI chr 8:12,943,453...12,963,966 JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TIMP1 mRNA]; ilomastat affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TIMP1 protein] CTD PMID:18837084 NCBI chr  X:3,766,509...3,772,578 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19869
      application 19715
        anti-inflammatory agent 16695
          ilomastat 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    main group molecular entity 19835
                      s-block molecular entity 19670
                        hydrogen molecular entity 19652
                          hydrides 19164
                            inorganic hydride 18180
                              pnictogen hydride 18170
                                nitrogen hydride 18083
                                  azane 17892
                                    ammonia 17891
                                      organic amino compound 17891
                                        amino acid 16077
                                          alpha-amino acid 13948
                                            L-alpha-amino acid 12152
                                              erythrose 4-phosphate/phosphoenolpyruvate family amino acid 2404
                                                L-tryptophan 21
                                                  L-tryptophan derivative 9
                                                    ilomastat 3
paths to the root