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Accession:CHEBI:137236 term browser browse the term
Definition:An N-acyl-amino acid obtained by formal condensation of the carboxy group of (2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the amino group of N-methyl-L-tryptophanamide. A cell permeable broad-spectrum matrix metalloproteinase (MMP) inhibitor
Synonyms:exact_synonym: (2R)-N(4)-hydroxy-N(1)-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide
 related_synonym: CS 610;   Formula=C20H28N4O4;   GM 6001;   GM6001;   InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1;   InChIKey=NITYDPDXAAFEIT-DYVFJYSZSA-N;   SMILES=C(C(NO)=O)[C@H](C(N[C@H](C(NC)=O)CC=1C=2C(NC1)=CC=CC2)=O)CC(C)C;   galardin
 alt_id: CHEBI:42919
 xref: CAS:142880-36-2 "ChemIDplus";   CAS:142880-36-2 "KEGG DRUG";   KEGG:D03793;   LINCS:LSM-3143
 xref_mesh: MESH:C119203
 xref: PDBeChem:GM6;   PMID:12410973 "Europe PMC";   PMID:14568001 "Europe PMC";   PMID:15350544 "Europe PMC";   PMID:16565079 "Europe PMC";   PMID:16712832 "Europe PMC";   PMID:18782669 "Europe PMC";   PMID:18790756 "Europe PMC";   PMID:18837084 "Europe PMC";   PMID:19545667 "Europe PMC";   PMID:20299089 "Europe PMC";   PMID:20818082 "Europe PMC";   PMID:21040999 "Europe PMC";   PMID:21146503 "Europe PMC";   PMID:22512086 "Europe PMC";   PMID:22903888 "Europe PMC";   PMID:23141517 "Europe PMC";   PMID:23870824 "Europe PMC";   PMID:24380772 "Europe PMC";   PMID:24589605 "Europe PMC";   PMID:25576979 "Europe PMC";   PMID:26171681 "Europe PMC";   PMID:26394037 "Europe PMC";   PMID:27038494 "Europe PMC";   PMID:27112177 "Europe PMC";   PMID:27296149 "Europe PMC";   PMID:27708133 "Europe PMC";   PMID:27743382 "Europe PMC";   PMID:28297575 "Europe PMC";   PMID:28298987 "Europe PMC";   PMID:28417261 "Europe PMC";   Reaxys:7982373 "Reaxys";   Wikipedia:Ilomastat

show annotations for term's descendants       view all columns           Sort by:
ilomastat term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:6480464
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:6480464
G Timp1 TIMP metallopeptidase inhibitor 1 JBrowse link X 1,364,771 1,369,451 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      application 19225
        anti-inflammatory agent 14899
          ilomastat 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic group 18338
                              organic divalent group 18329
                                organodiyl group 18329
                                  carbonyl group 18218
                                    carbonyl compound 18218
                                      carboxylic acid 17918
                                        amino acid 12312
                                          alpha-amino acid 7423
                                            L-alpha-amino acid 7080
                                              erythrose 4-phosphate/phosphoenolpyruvate family amino acid 2098
                                                L-tryptophan 6
                                                  L-tryptophan derivative 3
                                                    ilomastat 3
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.