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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor
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Accession:CHEBI:137123 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the activity of receptor protein serine/threonine kinase (EC 2.7.11.30).
Synonyms:related_synonym: ATP:[receptor-protein] phosphotransferase inhibitor;   ATP:[receptor-protein] phosphotransferase inhibitors;   EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitors;   EC 2.7.11.30 inhibitor;   EC 2.7.11.30 inhibitors;   STK13 inhibitor;   STK13 inhibitors;   TGF-beta kinase inhibitor;   TGF-beta kinase inhibitors;   activin receptor kinase inhibitor;   activin receptor kinase inhibitors;   inhibitor of receptor protein serine/threonine kinase;   receptor protein serine/threonine kinase inhibitors;   receptor serine/threonine protein kinase inhibitor;   receptor type I serine/threonine protein kinase inhibitor;   receptor type I serine/threonine protein kinase inhibitors;   receptor type II serine/threonine protein kinase inhibitor;   receptor type II serine/threonine protein kinase inhibitors
 xref: Wikipedia:Receptor_protein_serine/threonine_kinase



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LY 364947 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ephb1 Eph receptor B1 decreases phosphorylation ISO LY364947 decreases phosphorylation of EPHB1 protein in aortic smooth muscle cells RGD PMID:30787994 RGD:155260309 NCBI chr 8:102,507,549...102,944,839
Ensembl chr 8:102,507,549...102,944,839
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases phosphorylation ISO LY364947 decreases phosphorylation of SPP1 protein in aortic smooth muscle cells RGD PMID:30787994 RGD:155260309 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
LY-2157299 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of COL1A1 mRNA; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of CTNNB1 protein; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of FN1 protein; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of LAMC2 protein; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of TGFB1 mRNA; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the phosphorylation of SMAD2 protein CTD PMID:29808285 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Acan aggrecan decreases expression EXP LY-2157299 results in decreased expression of ACAN mRNA CTD PMID:29660438 NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO LY-2157299 inhibits the reaction [[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ACTA2 mRNA] CTD PMID:35366062 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of COL1A1 mRNA CTD PMID:29808285 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO LY-2157299 inhibits the reaction [[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of COL1A2 mRNA] CTD PMID:35366062 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Col2a1 collagen type II alpha 1 chain decreases expression EXP LY-2157299 results in decreased expression of COL2A1 mRNA CTD PMID:29660438 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of CTNNB1 protein CTD PMID:29808285 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of FN1 protein CTD PMID:29808285 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Lamc2 laminin subunit gamma 2 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of LAMC2 protein CTD PMID:29808285 NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the phosphorylation of SMAD2 protein CTD PMID:29808285 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP
ISO
LY-2157299 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:35122773 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP
[ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of TGFB1 mRNA
LY-2157299 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
LY-2157299 inhibits the reaction [[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ACTA2 mRNA]; LY-2157299 inhibits the reaction [[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of COL1A2 mRNA]; LY-2157299 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
CTD PMID:29808285 PMID:35122773 PMID:35366062 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases activity ISO LY-2157299 results in decreased activity of TGFBR1 protein CTD PMID:35122773 PMID:35366062 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19803
    role 19779
      biological role 19806
        inhibitor 18896
          enzyme inhibitor 18725
            EC 2.* (transferase) inhibitor 14851
              EC 2.7.* (P-containing group transferase) inhibitor 14366
                EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 10120
                  EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor 15
                    2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine 0
                    TGFbeta receptor antagonist + 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19803
    role 19779
      biological role 19806
        inhibitor 18896
          enzyme inhibitor 18725
            EC 2.* (transferase) inhibitor 14851
              EC 2.7.* (P-containing group transferase) inhibitor 14366
                protein kinase inhibitor 13961
                  EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 10120
                    EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor 15
                      2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine 0
                      TGFbeta receptor antagonist + 15
paths to the root