Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


go back to main search page
Accession:CHEBI:137064 term browser browse the term
Definition:A pyrrolopyrazole that is 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole which is substituted at positions 2 and 3 by 6-methylpyridin-2-yl and 6-(aminocarbonyl)quinolin-4-yl groups, respectively. A Transforming growth factor-betaRI (TGF-betaRI) kinase inhibitor, it blocks TGF-beta-mediated tumor growth in glioblastoma.
Synonyms:exact_synonym: 4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide
 related_synonym: Formula=C22H19N5O;   InChI=1S/C22H19N5O/c1-13-4-2-5-18(25-13)21-20(19-6-3-11-27(19)26-21)15-9-10-24-17-8-7-14(22(23)28)12-16(15)17/h2,4-5,7-10,12H,3,6,11H2,1H3,(H2,23,28);   InChIKey=IVRXNBXKWIJUQB-UHFFFAOYSA-N;   LY2157299;   SMILES=C12=C(C=CN=C1C=CC(=C2)C(N)=O)C=3C(=NN4C3CCC4)C=5N=C(C=CC5)C;   galunisertib;   galunisertibum
 xref: CAS:700874-72-2 "KEGG DRUG";   KEGG:D10437
 xref_mesh: MESH:C557799
 xref: PMCID:PMC3734332 "Europe PMC";   PMCID:PMC4055765 "Europe PMC";   PMCID:PMC4652527 "Europe PMC";   PMID:18039567 "Europe PMC";   PMID:23826206 "Europe PMC";   PMID:24868575 "Europe PMC";   PMID:25424852 "Europe PMC";   PMID:25488804 "Europe PMC";   PMID:25529192 "Europe PMC";   PMID:25573078 "Europe PMC";   PMID:26057634 "Europe PMC";   PMID:26137087 "Europe PMC";   PMID:26309397 "Europe PMC";   PMID:26526984 "Europe PMC";   PMID:26902851 "Europe PMC";   PMID:26976322 "Europe PMC";   PMID:27197172 "Europe PMC";   PMID:27509307 "Europe PMC";   PMID:27756784 "Europe PMC";   PMID:27990167 "Europe PMC";   PMID:28230858 "Europe PMC";   PMID:28405618 "Europe PMC";   PMID:28436712 "Europe PMC";   PMID:28451833 "Europe PMC";   PMID:28481241 "Europe PMC";   Reaxys:14275134 "Reaxys";   Wikipedia:Galunisertib

show annotations for term's descendants       view all columns           Sort by:
LY-2157299 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb4 ATP binding cassette subfamily B member 4 JBrowse link 4 22,133,984 22,192,687 RGD:6480464
G Acan aggrecan JBrowse link 1 140,762,758 140,824,441 RGD:6480464
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:6480464
G Col2a1 collagen type II alpha 1 chain JBrowse link 7 139,454,945 139,484,403 RGD:6480464
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6480464
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:6480464
G Lamc2 laminin subunit gamma 2 JBrowse link 13 70,566,643 70,632,126 RGD:6480464
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pharmaceutical 19097
          drug 19097
            antineoplastic agent 16555
              LY-2157299 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        carboacyl group 16943
                                          univalent carboacyl group 16943
                                            carbamoyl group 16622
                                              carboxamide 16622
                                                monocarboxylic acid amide 13180
                                                  LY-2157299 9
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.