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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-methoxy-17beta-estradiol
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Accession:CHEBI:136975 term browser browse the term
Definition:A 17beta-hydroxy steroid that is 17beta-estradiol in which the hydrogen at position 4 has been replaced by a methoxy group.
Synonyms:exact_synonym: 4-methoxyestra-1,3,5(10)-triene-3,17beta-diol
 related_synonym: (17beta)-4-methoxyestra-1,3,5(10)-triene-3,17-diol;   4-MeOE2;   4-Methoxy-3,17beta-dihydroxy-1,3,5[10]-estratriene;   4-Methoxyestradiol;   4-Methoxyestradiol-17beta;   Formula=C19H26O3;   InChI=1S/C19H26O3/c1-19-10-9-12-11-5-7-16(20)18(22-2)14(11)4-3-13(12)15(19)6-8-17(19)21/h5,7,12-13,15,17,20-21H,3-4,6,8-10H2,1-2H3/t12-,13-,15+,17+,19+/m1/s1;   InChIKey=BCWZIZLVBYHFES-PYEWSWHRSA-N;   SMILES=C=1C=2[C@]3(CC[C@]4([C@]([C@@]3(CCC2C(=C(C1)O)OC)[H])(CC[C@@H]4O)[H])C)[H]
 xref: CAS:26788-23-8;   HMDB:HMDB0012782
 xref_mesh: MESH:C045018
 xref: PMID:10403516;   PMID:12810639;   PMID:14962508;   PMID:15472229;   PMID:17397890;   PMID:20823587;   PMID:21344307;   PMID:21561814;   PMID:22159223;   PMID:23319542;   PMID:23319543;   PMID:23757313;   PMID:25433128;   PMID:26180245;   PMID:26460631;   PMID:28219710;   Reaxys:5753018


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4-methoxy-17beta-estradiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases abundance
multiple interactions		 ISO CYP1B1 protein results in increased abundance of 4-methoxyestradiol
Tetrachlorodibenzodioxin promotes the reaction [CYP1B1 protein results in increased abundance of 4-methoxyestradiol]; Tetradecanoylphorbol Acetate promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [CYP1B1 protein results in increased abundance of 4-methoxyestradiol]]		 CTD PMID:9706865 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19765
    role 19738
      biological role 19736
        molecular messenger 18583
          hormone 18436
            sex hormone 18240
              estrogen 18190
                4-methoxy-17beta-estradiol 1
                  4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19765
    subatomic particle 19763
      composite particle 19763
        hadron 19763
          baryon 19763
            nucleon 19763
              atomic nucleus 19763
                atom 19763
                  main group element atom 19712
                    p-block element atom 19712
                      carbon group element atom 19658
                        carbon atom 19654
                          organic molecular entity 19654
                            organic molecule 19616
                              organic cyclic compound 19425
                                organic polycyclic compound 17182
                                  steroid 14388
                                    hydroxy steroid 14106
                                      3-hydroxy steroid 12186
                                        phenolic steroid 10618
                                          estradiol 10613
                                            17beta-estradiol 10613
                                              4-methoxy-17beta-estradiol 1
                                                4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
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