antidote to sarin poisoning - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	antidote to sarin poisoning	go back to main search page
Accession:	CHEBI:136860	browse the term
Definition:	A role borne by a molecule that acts to counteract or neutralise the nerve agent sarin.

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Rat (104) Mouse (105) Human (105) Chinchilla (0) Bonobo (0) Dog (2) Squirrel (0) Pig (3) Green Monkey (0) Naked Mole-rat (0) All
Genes (104)

atropine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

Atropine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Atropine results in decreased activity of ABCB11 protein

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions

[Parathion co-treated with Atropine] results in increased expression of ABL1 mRNA

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

acetylcholinesterase

multiple interactions

Atropine inhibits the reaction [[Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine]; Atropine inhibits the reaction [Carbachol results in increased metabolism of and results in increased secretion of ACHE protein]; Atropine inhibits the reaction [Paraoxon results in increased expression of ACHE protein]
[Atropine co-treated with Obidoxime Chloride] inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein; [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; [tariquidar co-treated with asoxime chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]
[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with cucurbit(7)uril] co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]

PMID:2241428 PMID:10421444 PMID:17963125 PMID:20105433 PMID:21600273 More...

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

adenylate cyclase 5

increases response to substance

ADCY5 protein results in increased susceptibility to Atropine

NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974

G

aquaporin 5

multiple interactions

Atropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein]

NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209

G

BCL2 associated X, apoptosis regulator

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the expression of BAX mRNA]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCAR1 scaffold protein, Cas family member

multiple interactions

Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]]

NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907

G

butyrylcholinesterase

multiple interactions

[Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein
[BCHE protein co-treated with asoxime chloride co-treated with pro-diazepam co-treated with Atropine] results in decreased susceptibility to VX

PMID:17963125 PMID:22981459

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

bradykinin receptor B2

multiple interactions

BDKRB2 affects the susceptibility to [Propranolol co-treated with Atropine]

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

bone morphogenetic protein 6

multiple interactions

Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of BMP6 mRNA]

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

calcium voltage-gated channel subunit alpha1 E

multiple interactions

Atropine inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]]

NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450

G

calcitonin-related polypeptide alpha

affects activity

Atropine affects the activity of CALCA protein

PMID:7906887 PMID:10075105

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

caspase 3

increases expression

Atropine results in increased expression of CASP3 mRNA

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

C-C motif chemokine ligand 5

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 protein]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cyclin A1

increases expression
multiple interactions

Atropine results in increased expression of CCNA1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNA1 mRNA

NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157

G

cyclin D3

multiple interactions

[Parathion co-treated with Atropine] results in increased expression of CCND3 mRNA

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

cyclin E1

increases expression
multiple interactions

Atropine results in increased expression of CCNE1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNE1 mRNA

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin E2

multiple interactions
increases expression

[Parathion co-treated with Atropine] results in increased expression of CCNE2 mRNA
Atropine results in increased expression of CCNE2 mRNA

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

CD40 molecule

multiple interactions

Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein]

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

cell division cycle 20

multiple interactions
increases expression

[Parathion co-treated with Atropine] results in increased expression of CDC20 mRNA
Atropine results in increased expression of CDC20 mRNA

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

cell division cycle 6

multiple interactions

[Parathion co-treated with Atropine] results in increased expression of CDC6 mRNA

NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011

G

cyclin-dependent kinase 1

multiple interactions
increases expression

[Parathion co-treated with Atropine] results in increased expression of CDK1 mRNA
Atropine results in increased expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

carboxylesterase 1D

multiple interactions

Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

cholinergic receptor, muscarinic 1

multiple interactions
decreases activity

Atropine binds to and results in decreased activity of CHRM1 protein; Atropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
Atropine results in decreased activity of CHRM1 protein
Atropine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]

PMID:16439611 PMID:18316702 PMID:31830555

NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356

G

cholinergic receptor, muscarinic 2

multiple interactions

Atropine binds to and results in decreased activity of CHRM2 protein

NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103

G

cholinergic receptor, muscarinic 3

multiple interactions
decreases activity

Atropine binds to and results in decreased activity of CHRM3 protein; Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]
Atropine results in decreased activity of CHRM3 protein

PMID:15140916 PMID:20708676 PMID:31830555

NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278

G

cholinergic receptor, muscarinic 4

multiple interactions
affects binding

[WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Atropine binds to CHRM4 protein]

NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159

G

cholinergic receptor, muscarinic 5

multiple interactions

Atropine inhibits the reaction [Acetylcholine results in increased activity of CHRM5 protein]

NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions
affects binding

Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]]
Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]

PMID:15733544 PMID:21791372

NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic beta 2 subunit

affects binding
multiple interactions

Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]]
Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]

PMID:15733544 PMID:21791372

NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619

G

cAMP responsive element binding protein 1

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein]

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

corticotropin releasing hormone

multiple interactions

Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]; Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]; Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein]
[Atropine co-treated with SR 140333 co-treated with SR 48968] results in decreased activity of CRH protein

PMID:12039681 PMID:12906840

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

catenin beta 1

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein mutant form]; Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

C-X-C motif chemokine ligand 3

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 protein]

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

dishevelled segment polarity protein 2

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of DVL2 protein]

NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820

G

endothelin 1

multiple interactions

EDN1 protein results in decreased activity of [Atropine co-treated with Histamine]

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

eukaryotic translation elongation factor 2

multiple interactions

atropine inhibits the reaction [carbachol decreases phosphorylation of EEF2 protein in colon cancer cells]

RGD

NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183

G

epidermal growth factor receptor

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

early growth response 1

multiple interactions

Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA]

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

early growth response 2

multiple interactions

Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA]

NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562

G

ezrin

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of EZR protein]

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

coagulation factor II, thrombin

multiple interactions

[Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in decreased expression of F2 mRNA; [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased activity of F2 protein

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

coagulation factor II (thrombin) receptor

multiple interactions

[Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased expression of F2R protein

NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

Atropine results in increased expression of FOS protein
Atropine inhibits the reaction [Paraoxon results in increased expression of FOS mRNA]
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased expression of FOS protein]; Atropine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]

PMID:7968354 PMID:8281324 PMID:21787676 PMID:21971501

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

ghrelin and obestatin prepropeptide

multiple interactions

Atropine inhibits the reaction [[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein]

NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621

G

glycine receptor, alpha 1

multiple interactions

Atropine binds to and results in decreased activity of GLRA1 protein

NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162

G

glutamate metabotropic receptor 4

multiple interactions

Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]

NCBI chr20:5,484,172...5,572,821
Ensembl chr20:5,481,124...5,572,821

G

intercellular adhesion molecule 1

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 protein]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 1 beta

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

[Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 mRNA]; [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Atropine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

potassium inwardly-rectifying channel, subfamily J, member 3

multiple interactions

Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]

NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124

G

KIT proto-oncogene receptor tyrosine kinase

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of KIT protein]

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

lactotransferrin

multiple interactions

Atropine inhibits the reaction [methylcholine results in increased secretion of LTF protein]

NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795

G

mitogen activated protein kinase 1

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK14 protein]

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

minichromosome maintenance complex component 4

multiple interactions
increases expression

[Parathion co-treated with Atropine] results in increased expression of MCM4 mRNA
Atropine results in increased expression of MCM4 mRNA

NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144

G

minichromosome maintenance complex component 6

increases expression
multiple interactions

Atropine results in increased expression of MCM6 mRNA
[Parathion co-treated with Atropine] results in increased expression of MCM6 mRNA

NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960

G

neurofilament heavy chain

affects expression

Atropine affects the expression of NEFH mRNA

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

G

NLR family, pyrin domain containing 3

increases expression

Atropine results in increased expression of NLRP3 mRNA

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

nitric oxide synthase 2

multiple interactions

Atropine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Atropine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]

PMID:15610444 PMID:16944022

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

notch receptor 4

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of NOTCH4 protein]

NCBI chr20:4,160,362...4,184,466
Ensembl chr20:4,160,445...4,184,465

G

natriuretic peptide A

affects activity

Atropine affects the activity of NPPA protein modified form

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

opioid related nociceptin receptor 1

multiple interactions

Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]

NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920

G

proliferating cell nuclear antigen

multiple interactions

Atropine inhibits the reaction [Malathion results in increased expression of PCNA]; Atropine inhibits the reaction [Parathion results in increased expression of PCNA]

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

prepronociceptin

multiple interactions

Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]

NCBI chr15:39,624,635...39,652,463
Ensembl chr15:39,624,641...39,651,867

G

proopiomelanocortin

multiple interactions

Atropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein]

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

peroxisome proliferator activated receptor alpha

multiple interactions

[Atropine co-treated with Glucose] binds to PPARA protein; Atropine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Atropine affects the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA]

PMID:15104355 PMID:15610444 PMID:16259740 PMID:16804302

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

multiple interactions

Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]]

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

paxillin

multiple interactions

Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]]

NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931

G

Rac family small GTPase 3

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of RAC3 protein]

NCBI chr10:106,002,808...106,005,243
Ensembl chr10:105,993,087...106,005,260

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ras homolog family member A

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of RHOA protein]

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

solute carrier family 22 member 1

multiple interactions

Atropine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

PMID:16263091 PMID:21641380

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 2

multiple interactions

Atropine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]

PMID:16263091 PMID:21599003 PMID:23770354

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 3

increases uptake
multiple interactions

SLC22A3 protein results in increased uptake of Atropine
Atropine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612

G

solute carrier family 22 member 4

multiple interactions

Atropine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]

NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720

G

solute carrier family 47 member 1

multiple interactions

Atropine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 47 member 2

multiple interactions

Atropine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904

G

secretory leukocyte peptidase inhibitor

increases expression

Atropine results in increased expression of SLPI mRNA

NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453

G

suppressor of cytokine signaling 3

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of SOCS3 mRNA]

NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787

G

sialophorin

increases response to substance

SPN protein results in increased susceptibility to Atropine

NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628

G

tyrosine aminotransferase

multiple interactions

[Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein]

NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031

G

transforming growth factor, beta 1

multiple interactions

Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

multiple interactions

Atropine inhibits the reaction [Malathion results in increased expression of TP53 protein]; Atropine inhibits the reaction [Parathion results in increased expression of TP53 protein]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

trio Rho guanine nucleotide exchange factor

multiple interactions

Atropine inhibits the reaction [Parathion results in increased expression of TRIO protein]

NCBI chr 2:78,505,069...78,801,384
Ensembl chr 2:78,505,070...78,803,135

G

transient receptor potential cation channel, subfamily A, member 1

decreases response to substance

TRPA1 gene mutant form results in decreased susceptibility to Atropine

NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570

G

thyroid stimulating hormone subunit beta

multiple interactions

[pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein]

NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559

G

translocator protein

multiple interactions

[Ketamine co-treated with Midazolam co-treated with Valproic Acid] inhibits the reaction [[Sarin co-treated with [Atropine co-treated with trimethylene-bis(4-hydroxyiminomethylpyridinium)]] results in increased expression of TSPO protein]; [Sarin co-treated with [Atropine co-treated with trimethylene-bis(4-hydroxyiminomethylpyridinium)]] results in increased expression of TSPO protein

NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450

G

vascular cell adhesion molecule 1

multiple interactions

[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of VCAM1 mRNA]

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

biperiden

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

Biperiden results in decreased activity of ABCB4 protein

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

bone morphogenetic protein 6

increases expression

Biperiden results in increased expression of BMP6 mRNA

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

cholinergic receptor, muscarinic 1

multiple interactions

Biperiden binds to and results in decreased activity of CHRM1 protein

NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356

G

epiregulin

increases expression

Biperiden results in increased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

interleukin 1 alpha

increases expression

Biperiden results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression

Biperiden results in increased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 24

increases expression

Biperiden results in increased expression of IL24 mRNA

NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

Biperiden results in increased expression of MET mRNA

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

phosphotyrosine interaction domain containing 1

increases expression

Biperiden results in increased expression of PID1 mRNA

NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044

G

solute carrier family 7 member 11

increases expression

Biperiden results in increased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

pralidoxime

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

affects binding
multiple interactions

pralidoxime binds to ACHE protein
pralidoxime binds to and results in decreased activity of ACHE protein; pralidoxime inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Malathion results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [tabun results in decreased activity of ACHE protein]
[Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Methyl Parathion co-treated with pralidoxime] results in decreased expression of ACHE protein; [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein; [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Sarin analog results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Sarin results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [VX analog results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]
pralidoxime inhibits the reaction [Chlorfenvinphos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Chlorpyrifos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Cholinesterase Inhibitors binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [cyclohexyl methylphosphonofluoridate binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [cyclohexyl methylphosphonofluoridate results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Diazinon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [dicrotophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Dimethoate results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [dimethoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [ethylparaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [heptenophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [leptophos oxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Malathion results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [methamidophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [methyl demeton results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [methylparaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Obidoxime Chloride results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Organophosphates binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Organophosphorus Compounds results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein mutant form]; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Phosphamidon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Sarin analog results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Sarin binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Sarin results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Soman results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [tabun binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [tabun results in decreased activity of ACHE protein mutant form]; pralidoxime inhibits the reaction [tabun results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [VX analog results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [VX binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [VX results in decreased activity of ACHE protein]; pralidoxime metabolite inhibits the reaction [Sarin results in decreased activity of ACHE protein]; pralidoxime metabolite inhibits the reaction [VX results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [Carbaryl results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [Propoxur results in decreased activity of ACHE protein]

PMID:1494302 PMID:8134223 PMID:8783813 PMID:15669039 PMID:16025528 More...

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

butyrylcholinesterase

multiple interactions
affects binding

pralidoxime binds to and results in decreased activity of BCHE protein
[Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime] results in decreased expression of BCHE protein; pralidoxime affects the reaction [4-nitrophenyl 2-propylmethylphosphonate results in decreased activity of BCHE protein]; pralidoxime affects the reaction [ethyl 4-nitrophenyl methylphosphonate results in decreased activity of BCHE protein]
BCHE protein binds to pralidoxime
pralidoxime binds to and affects the activity of BCHE protein; pralidoxime inhibits the reaction [Chlorpyrifos results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Cholinesterase Inhibitors binds to and results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Isoflurophate inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]]; pralidoxime inhibits the reaction [Isoflurophate results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Organophosphates binds to and results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [quinalphos results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Sarin analog inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]]; pralidoxime inhibits the reaction [Sarin analog results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [VX analog results in decreased activity of BCHE protein]

PMID:423703 PMID:16598855 PMID:17963125 PMID:18825528 PMID:20227398 More...

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

catalase

multiple interactions

[Malathion co-treated with pralidoxime] results in increased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

paraoxonase 1

multiple interactions

pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein]

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

solute carrier family 22 member 2

multiple interactions

pralidoxime inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

thyroid stimulating hormone subunit beta

multiple interactions

[pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein]

NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19880
role	19850
application	19695
pharmaceutical	19532
drug	19532
protective agent	18242
antidote	9610
antidote to sarin poisoning	104
atropine +	95
biperiden +	10
pralidoxime +	6

paths to the root