Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:antidote to sarin poisoning
go back to main search page
Accession:CHEBI:136860 term browser browse the term
Definition:A role borne by a molecule that acts to counteract or neutralise the nerve agent sarin.


show annotations for term's descendants           Sort by:
 
atropine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Atropine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Atropine results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO [Parathion co-treated with Atropine] results in increased expression of ABL1 mRNA CTD PMID:17390078 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO
EXP
Atropine inhibits the reaction [[Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine]; Atropine inhibits the reaction [Carbachol results in increased metabolism of and results in increased secretion of ACHE protein]; Atropine inhibits the reaction [Paraoxon results in increased expression of ACHE protein]
[Atropine co-treated with Obidoxime Chloride] inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein; [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; [tariquidar co-treated with asoxime chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]
[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [[1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide co-treated with cucurbit(7)uril] co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Atropine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Atropine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]
CTD PMID:2241428, PMID:10421444, PMID:17963125, PMID:20105433, PMID:21600273, PMID:21787676, PMID:22783142, PMID:23047022, PMID:24881594, PMID:26751814, PMID:31794810 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Adcy5 adenylate cyclase 5 increases response to substance ISO ADCY5 protein results in increased susceptibility to Atropine CTD PMID:12869393 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320
JBrowse link
G Aqp5 aquaporin 5 multiple interactions ISO Atropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein] CTD PMID:26208470 NCBI chr 7:141,249,044...141,252,576
Ensembl chr 7:141,249,044...141,252,578
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the expression of BAX mRNA] CTD PMID:21971501 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member multiple interactions ISO Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]] CTD PMID:10537051 NCBI chr19:43,932,543...43,967,452
Ensembl chr19:43,932,554...43,955,783
JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP
ISO
[Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein
[BCHE protein co-treated with asoxime chloride co-treated with pro-diazepam co-treated with Atropine] results in decreased susceptibility to VX
CTD PMID:17963125, PMID:22981459 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions ISO BDKRB2 affects the susceptibility to [Propranolol co-treated with Atropine] CTD PMID:10614985 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions EXP Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of BMP6 mRNA] CTD PMID:18472332 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E multiple interactions EXP Atropine inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]] CTD PMID:12663092 NCBI chr13:71,899,445...72,534,992
Ensembl chr13:71,906,702...72,367,980
JBrowse link
G Calca calcitonin-related polypeptide alpha affects activity EXP Atropine affects the activity of CALCA protein CTD PMID:7906887, PMID:10075105 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Casp3 caspase 3 increases expression EXP Atropine results in increased expression of CASP3 mRNA CTD PMID:19815060 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 protein] CTD PMID:22245128 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccna1 cyclin A1 increases expression
multiple interactions
ISO Atropine results in increased expression of CCNA1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNA1 mRNA
CTD PMID:17390078 NCBI chr 2:144,456,689...144,503,570
Ensembl chr 2:144,458,153...144,467,912
JBrowse link
G Ccnd3 cyclin D3 multiple interactions ISO [Parathion co-treated with Atropine] results in increased expression of CCND3 mRNA CTD PMID:17390078 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 increases expression
multiple interactions
ISO Atropine results in increased expression of CCNE1 mRNA
[Parathion co-treated with Atropine] results in increased expression of CCNE1 mRNA
CTD PMID:17390078 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccne2 cyclin E2 multiple interactions
increases expression
ISO [Parathion co-treated with Atropine] results in increased expression of CCNE2 mRNA
Atropine results in increased expression of CCNE2 mRNA
CTD PMID:17390078 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Cd40 CD40 molecule multiple interactions ISO Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein] CTD PMID:16879495 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cdc20 cell division cycle 20 multiple interactions
increases expression
ISO [Parathion co-treated with Atropine] results in increased expression of CDC20 mRNA
Atropine results in increased expression of CDC20 mRNA
CTD PMID:17390078 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Cdc6 cell division cycle 6 multiple interactions ISO [Parathion co-treated with Atropine] results in increased expression of CDC6 mRNA CTD PMID:17390078 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
increases expression
ISO [Parathion co-treated with Atropine] results in increased expression of CDK1 mRNA
Atropine results in increased expression of CDK1 mRNA
CTD PMID:17390078 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] CTD PMID:9311626 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions
decreases activity
ISO Atropine binds to and results in decreased activity of CHRM1 protein; Atropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
Atropine results in decreased activity of CHRM1 protein
Atropine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]
CTD PMID:16439611, PMID:18316702, PMID:31830555 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO Atropine binds to and results in decreased activity of CHRM2 protein CTD PMID:15140916 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions
decreases activity
ISO Atropine binds to and results in decreased activity of CHRM3 protein; Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]
Atropine results in decreased activity of CHRM3 protein
CTD PMID:15140916, PMID:20708676, PMID:31830555 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions
affects binding
ISO [WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Atropine binds to CHRM4 protein] CTD PMID:16709648 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 multiple interactions ISO Atropine inhibits the reaction [Acetylcholine results in increased activity of CHRM5 protein] CTD PMID:31323226 NCBI chr 3:103,966,451...104,018,815
Ensembl chr 3:103,966,451...104,018,861
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions
affects binding
ISO
EXP
Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]]
Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]
CTD PMID:15733544, PMID:21791372 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit affects binding
multiple interactions
ISO
EXP
Atropine binds to [CHRNA4 protein binds to CHRNB2 protein]
Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]]
Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD PMID:15733544, PMID:21791372 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein] CTD PMID:21971501 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crh corticotropin releasing hormone multiple interactions EXP
ISO
Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]; Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]; Atropine inhibits the reaction [methamidophos results in increased expression of CRH mRNA]; Atropine inhibits the reaction [methamidophos results in increased secretion of CRH protein]
[Atropine co-treated with SR 140333 co-treated with SR 48968] results in decreased activity of CRH protein
CTD PMID:12039681, PMID:12906840 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein mutant form]; Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein] CTD PMID:17390078 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 protein] CTD PMID:22245128 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Dvl2 dishevelled segment polarity protein 2 multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of DVL2 protein] CTD PMID:17390078 NCBI chr10:56,609,810...56,619,269
Ensembl chr10:56,610,051...56,619,269
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO EDN1 protein results in decreased activity of [Atropine co-treated with Histamine] CTD PMID:12906840 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of EGFR protein] CTD PMID:17390078 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 multiple interactions EXP Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA] CTD PMID:7968354 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Egr2 early growth response 2 multiple interactions EXP Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA] CTD PMID:7968354 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025
JBrowse link
G Ezr ezrin multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of EZR protein] CTD PMID:17390078 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP
ISO
Atropine results in increased expression of FOS protein
Atropine inhibits the reaction [Paraoxon results in increased expression of FOS mRNA]
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased expression of FOS protein]; Atropine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]
CTD PMID:7968354, PMID:8281324, PMID:21787676, PMID:21971501 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions EXP Atropine inhibits the reaction [[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein] CTD PMID:16959836 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066
JBrowse link
G Glra1 glycine receptor, alpha 1 multiple interactions ISO Atropine binds to and results in decreased activity of GLRA1 protein CTD PMID:15081878 NCBI chr10:40,851,955...40,954,364
Ensembl chr10:40,855,559...40,953,651
JBrowse link
G Grm4 glutamate metabotropic receptor 4 multiple interactions ISO Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr20:6,745,682...6,791,521
Ensembl chr20:6,745,682...6,791,519
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 protein] CTD PMID:22245128 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B protein] CTD PMID:22245128 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 mRNA]; [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 protein] CTD PMID:22245128 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of JUN protein] CTD PMID:21971501 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Atropine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA] CTD PMID:7968354 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr 3:41,019,898...41,181,070
Ensembl chr 3:41,019,898...41,181,070
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of KIT protein] CTD PMID:17390078 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Ltf lactotransferrin multiple interactions ISO Atropine inhibits the reaction [methylcholine results in increased secretion of LTF protein] CTD PMID:11112886 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK1 protein] CTD PMID:21971501 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK14 protein] CTD PMID:21971501 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK3 protein] CTD PMID:21971501 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK8 protein] CTD PMID:21971501 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 multiple interactions
increases expression
ISO [Parathion co-treated with Atropine] results in increased expression of MCM4 mRNA
Atropine results in increased expression of MCM4 mRNA
CTD PMID:17390078 NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 increases expression
multiple interactions
ISO Atropine results in increased expression of MCM6 mRNA
[Parathion co-treated with Atropine] results in increased expression of MCM6 mRNA
CTD PMID:17390078 NCBI chr13:45,042,882...45,068,073
Ensembl chr13:45,042,882...45,068,077
JBrowse link
G Nefh neurofilament heavy affects expression EXP Atropine affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression ISO Atropine results in increased expression of NLRP3 mRNA CTD PMID:28138970 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Atropine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Atropine inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA] CTD PMID:15610444, PMID:16944022 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Notch4 notch receptor 4 multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of NOTCH4 protein] CTD PMID:17390078 NCBI chr20:4,329,794...4,353,868
Ensembl chr20:4,329,811...4,353,785
JBrowse link
G Nppa natriuretic peptide A affects activity EXP Atropine affects the activity of NPPA protein modified form CTD PMID:1363893 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 multiple interactions EXP Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein] CTD PMID:12007927 NCBI chr 3:177,223,779...177,231,663
Ensembl chr 3:177,225,737...177,231,663
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Atropine inhibits the reaction [Malathion results in increased expression of PCNA]; Atropine inhibits the reaction [Parathion results in increased expression of PCNA] CTD PMID:12762645 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pnoc prepronociceptin multiple interactions EXP Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein] CTD PMID:12007927 NCBI chr15:48,805,841...48,833,071
Ensembl chr15:48,805,228...48,833,285
JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP Atropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein] CTD PMID:7588217 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Atropine co-treated with Glucose] binds to PPARA protein; Atropine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] CTD PMID:18812576 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Atropine affects the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]; Atropine inhibits the reaction [Indomethacin results in increased expression of PTGS2]; Atropine inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA] CTD PMID:15104355, PMID:15610444, PMID:16259740, PMID:16804302 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]] CTD PMID:10537051 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Pxn paxillin multiple interactions ISO Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]] CTD PMID:10537051 NCBI chr12:46,797,953...46,845,107
Ensembl chr12:46,797,954...46,845,080
JBrowse link
G Rac3 Rac family small GTPase 3 multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of RAC3 protein] CTD PMID:17390078 NCBI chr10:109,903,920...109,906,596
Ensembl chr10:109,904,259...109,906,232
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of RELA protein] CTD PMID:21971501 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of RHOA protein] CTD PMID:17390078 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Atropine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091, PMID:21641380 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Atropine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Atropine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:16263091, PMID:21599003, PMID:23770354 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 increases uptake
multiple interactions
ISO SLC22A3 protein results in increased uptake of Atropine
Atropine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]
CTD PMID:16263091 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO Atropine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] CTD PMID:21641380 NCBI chr10:39,334,972...39,373,508 JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Atropine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Atropine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of SOCS3 mRNA] CTD PMID:22245128 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Spn sialophorin increases response to substance ISO SPN protein results in increased susceptibility to Atropine CTD PMID:18711009 NCBI chr 1:198,572,999...198,585,664
Ensembl chr 1:198,572,999...198,577,226
JBrowse link
G Tat tyrosine aminotransferase multiple interactions EXP [Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein] CTD PMID:7761789 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA] CTD PMID:18472332 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF protein] CTD PMID:22245128 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Atropine inhibits the reaction [Malathion results in increased expression of TP53 protein]; Atropine inhibits the reaction [Parathion results in increased expression of TP53 protein] CTD PMID:12762645 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trio trio Rho guanine nucleotide exchange factor multiple interactions ISO Atropine inhibits the reaction [Parathion results in increased expression of TRIO protein] CTD PMID:17390078 NCBI chr 2:80,471,398...80,769,313
Ensembl chr 2:80,473,202...80,667,481
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 decreases response to substance ISO TRPA1 gene mutant form results in decreased susceptibility to Atropine CTD PMID:29627347 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions EXP [pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein] CTD PMID:15891268 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of VCAM1 mRNA] CTD PMID:22245128 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
biperiden term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Biperiden results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions EXP Biperiden binds to and results in decreased activity of CHRM1 protein CTD PMID:21336581 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
pralidoxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase affects binding
multiple interactions
ISO
EXP
pralidoxime binds to ACHE protein
pralidoxime inhibits the reaction [Chlorfenvinphos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Chlorpyrifos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Cholinesterase Inhibitors binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [cyclohexyl methylphosphonofluoridate binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [cyclohexyl methylphosphonofluoridate results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Diazinon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [dicrotophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Dimethoate results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [dimethoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [ethylparaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [heptenophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [leptophos oxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Malathion results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [methamidophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [methyl demeton results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [methylparaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Obidoxime Chloride results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Organophosphates binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Organophosphorus Compounds results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein mutant form]; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Phosphamidon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Sarin analog results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Sarin binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Sarin results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Soman results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [tabun binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [tabun results in decreased activity of ACHE protein mutant form]; pralidoxime inhibits the reaction [tabun results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [VX analog results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [VX binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [VX results in decreased activity of ACHE protein]; pralidoxime metabolite inhibits the reaction [Sarin results in decreased activity of ACHE protein]; pralidoxime metabolite inhibits the reaction [VX results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [Carbaryl results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [Propoxur results in decreased activity of ACHE protein]
[Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Methyl Parathion co-treated with pralidoxime] results in decreased expression of ACHE protein; [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein; [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Sarin analog results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Sarin results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [VX analog results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]
pralidoxime binds to and results in decreased activity of ACHE protein; pralidoxime inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Malathion results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [tabun results in decreased activity of ACHE protein]
CTD PMID:1494302, PMID:8134223, PMID:8783813, PMID:15669039, PMID:16025528, PMID:16112538, PMID:16598855, PMID:17265452, PMID:17963125, PMID:18070496, PMID:18344198, PMID:18804659, PMID:19917271, PMID:20096273, PMID:20156430, PMID:20227398, PMID:20382137, PMID:20406208, PMID:20412789, PMID:20433814, PMID:20688148, PMID:20971170, PMID:21673941, PMID:21723318, PMID:21983245, PMID:22783142, PMID:22960624, PMID:22975155, PMID:23073172, PMID:23111374, PMID:23123249, PMID:23962483, PMID:25451328, PMID:25743373, PMID:26070418, PMID:26210933, PMID:26368669, PMID:26751814, PMID:27129421, PMID:27138243, PMID:27551891, PMID:29614332, PMID:29772260, PMID:29920286, PMID:31276662 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Bche butyrylcholinesterase multiple interactions
affects binding
ISO
EXP
pralidoxime binds to and results in decreased activity of BCHE protein
[Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime] results in decreased expression of BCHE protein; pralidoxime affects the reaction [4-nitrophenyl 2-propylmethylphosphonate results in decreased activity of BCHE protein]; pralidoxime affects the reaction [ethyl 4-nitrophenyl methylphosphonate results in decreased activity of BCHE protein]
BCHE protein binds to pralidoxime
pralidoxime binds to and affects the activity of BCHE protein; pralidoxime inhibits the reaction [Chlorpyrifos results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Cholinesterase Inhibitors binds to and results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Isoflurophate inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]]; pralidoxime inhibits the reaction [Isoflurophate results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Organophosphates binds to and results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [quinalphos results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Sarin analog inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]]; pralidoxime inhibits the reaction [Sarin analog results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [VX analog results in decreased activity of BCHE protein]
CTD PMID:423703, PMID:16598855, PMID:17963125, PMID:18825528, PMID:20227398, PMID:21802514, PMID:22922115, PMID:24052565, PMID:26705700, PMID:27551891, PMID:29614332, PMID:29920286, PMID:31173753, PMID:32278739 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Cat catalase multiple interactions ISO [Malathion co-treated with pralidoxime] results in increased activity of CAT protein CTD PMID:21723318 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Pon1 paraoxonase 1 multiple interactions EXP pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein] CTD PMID:29098328 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO pralidoxime inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions EXP [pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein] CTD PMID:15891268 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      application 19385
        pharmaceutical 19255
          drug 19255
            protective agent 16359
              antidote 7642
                antidote to sarin poisoning 93
                  atropine + 90
                  biperiden + 2
                  pralidoxime + 6
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.