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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:beta-bitter acid
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Accession:CHEBI:136848 term browser browse the term
Definition:An alicyclic ketone obtained by prenylation at positions 4, 6 and 6 of any 2-acylphloroglucinol. beta-bitter acids are well known for their contribution to the bitter taste of beer.
Synonyms:related_synonym: Formula=C22H29O4R;   SMILES=C=1(C(C(C(C(*)=O)=C(C1CC=C(C)C)O)=O)(CC=C(C)C)CC=C(C)C)O;   beta-bitter acids
 xref: MetaCyc:BETA-ACIDS;   PMID:25564559;   PMID:27976466
 cyclic_relationship: is_conjugate_acid_of CHEBI:134348


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lupulone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator affects expression ISO lupulon affects the expression of BAX protein CTD PMID:17434926 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO lupulon affects the expression of BCL2 protein CTD PMID:17434926 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO lupulon results in increased expression of FAS protein CTD PMID:17434926 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand increases expression ISO lupulon results in increased expression of FASLG protein CTD PMID:17434926 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO lupulon results in increased expression of TNFRSF10A protein CTD PMID:17434926 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      biological role 19902
        biochemical role 19598
          metabolite 19585
            eukaryotic metabolite 19403
              plant metabolite 17988
                beta-bitter acid 5
                  adlupulone 0
                  colupulone 0
                  lupulone 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            organic molecule 19764
                              organic cyclic compound 19553
                                organic aromatic compound 19414
                                  phenols 18680
                                    phenolic donor 601
                                      phloroglucinol 65
                                        2-acylphloroglucinol 5
                                          beta-bitter acid 5
                                            adlupulone 0
                                            colupulone 0
                                            lupulone 5
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