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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:eupatorin
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Accession:CHEBI:136666 term browser browse the term
Definition:A trimethoxyflavone that is 6-hydroxyluteolin in which the phenolic hydogens at positions 4', 6 and 7 have been replaced by methyl groups.
Synonyms:exact_synonym: 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-6,7-dimethoxy-4H-1-benzopyran-4-one
 related_synonym: 3',5-dihydroxy-4',6,7-trimethoxyflavone;   Eupatorine;   Formula=C18H16O7;   InChI=1S/C18H16O7/c1-22-12-5-4-9(6-10(12)19)13-7-11(20)16-14(25-13)8-15(23-2)18(24-3)17(16)21/h4-8,19,21H,1-3H3;   InChIKey=KLAOKWJLUQKWIF-UHFFFAOYSA-N;   SMILES=O1C=2C(=C(O)C(OC)=C(OC)C2)C(=O)C=C1C3=CC(O)=C(OC)C=C3
 xref: AGR:IND43745404;   AGR:IND605417569;   CAS:855-96-9;   Chemspider:87743;   KNApSAcK:C00003894;   LIPID_MAPS_instance:LMPK12111239
 xref_mesh: MESH:C103110
 xref: PMID:18454852;   PMID:19601638;   PMID:22227008;   PMID:22516932;   PMID:22698713;   PMID:22898066;   PMID:23839090;   PMID:24422962;   PMID:25390937;   PMID:25442272;   PMID:25598631;   PMID:26281557;   PMID:26322527;   PMID:26404257;   PMID:26649063;   PMID:26983579;   PMID:27187805;   PMID:27370961;   PMID:27470387;   PMID:27679866;   PMID:27695261;   PMID:27834876;   PMID:27991400;   PMID:28044092;   PMID:28347190;   PMID:29373904;   PMID:5847037;   PMID:905420;   Reaxys:1355109


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eupatorin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases response to substance
increases metabolic processing
decreases activity
increases expression
ISO CYP1A1 protein results in increased susceptibility to eupatorin
CYP1A1 protein results in increased metabolism of eupatorin analog
eupatorin analog results in decreased activity of CYP1A1 protein
eupatorin results in increased expression of CYP1A1 mRNA
CTD PMID:18454852 PMID:19601638 PMID:21482471 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
increases expression
decreases activity
ISO CYP1B1 protein results in increased metabolism of eupatorin analog
eupatorin results in increased expression of CYP1B1 mRNA
eupatorin results in decreased activity of CYP1B1 protein
CTD PMID:19601638 PMID:21482471 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO eupatorin results in decreased activity of CYP2C19 protein CTD PMID:21093571 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO eupatorin results in decreased activity of CYP2D6 protein CTD PMID:21276781 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO eupatorin results in decreased activity of CYP3A4 protein CTD PMID:21276781 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        anti-inflammatory agent 15831
          eupatorin 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  oxacycle 17587
                                    benzopyran 10402
                                      1-benzopyran 10129
                                        flavonoid 6513
                                          flavones 4203
                                            hydroxyflavone 4191
                                              3'-hydroxyflavonoid 254
                                                luteolin 198
                                                  6-hydroxyluteolin 5
                                                    eupatorin 5
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