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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:S100 calcium-binding protein B inhibitor
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Accession:CHEBI:136651 term browser browse the term
Definition:Any inhibitor of S100 calcium-binding protein B.
Synonyms:related_synonym: S100 calcium-binding protein B inhibitors;   S100B inhibitor;   S100B inhibitors
 xref: Wikipedia:S100B


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pentamidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AR androgen receptor multiple interactions EXP Pentamidine binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G ASIC5 acid sensing ion channel subunit family member 5 decreases activity ISO Pentamidine results in decreased activity of ASIC5 protein CTD PMID:21828194 NCBI chr 4:155,829,699...155,867,303
Ensembl chr 4:155,829,729...155,866,277
JBrowse link
G ASNS asparagine synthetase (glutamine-hydrolyzing) increases expression EXP Pentamidine results in increased expression of ASNS mRNA CTD PMID:15342952 NCBI chr 7:97,851,677...97,928,441
Ensembl chr 7:97,851,677...97,872,542
JBrowse link
G ATM ATM serine/threonine kinase affects localization
decreases activity
EXP Pentamidine affects the localization of ATM protein modified form
Pentamidine results in decreased activity of ATM protein
CTD PMID:20144237 NCBI chr11:108,222,484...108,369,102
Ensembl chr11:108,222,832...108,369,102
Ensembl chr11:108,222,832...108,369,102
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP [Pentamidine co-treated with lipopolysaccharide, E. coli O26-B6] results in decreased expression of CXCL8 mRNA CTD PMID:29594315 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases activity EXP Pentamidine results in decreased activity of CYP2C19 protein CTD PMID:11124226 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 decreases activity EXP Pentamidine results in decreased activity of CYP2C9 protein CTD PMID:11124226 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 decreases activity EXP Pentamidine results in decreased activity of CYP2D6 protein CTD PMID:11124226 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases activity EXP Pentamidine results in decreased activity of CYP3A4 protein CTD PMID:11124226 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DEPP1 DEPP1 autophagy regulator increases expression EXP Pentamidine results in increased expression of DEPP1 mRNA CTD PMID:15342952 NCBI chr10:44,976,128...44,978,809
Ensembl chr10:44,970,981...44,978,809
JBrowse link
G FABP1 fatty acid binding protein 1 decreases expression EXP Pentamidine results in decreased expression of FABP1 mRNA CTD PMID:15342952 NCBI chr 2:88,122,982...88,128,062
Ensembl chr 2:88,122,982...88,128,062
JBrowse link
G FNDC4 fibronectin type III domain containing 4 increases expression EXP Pentamidine results in increased expression of FNDC4 mRNA CTD PMID:15342952 NCBI chr 2:27,491,883...27,495,502
Ensembl chr 2:27,491,883...27,495,200
JBrowse link
G H2AX H2A.X variant histone affects localization EXP Pentamidine affects the localization of H2AX protein modified form CTD PMID:20144237 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,854...119,095,467
JBrowse link
G HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 affects expression EXP Pentamidine affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr 6:32,659,467...32,666,657
Ensembl chr 6:32,659,467...32,668,383
JBrowse link
G HPN hepsin increases expression EXP Pentamidine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr19:35,040,506...35,066,573
Ensembl chr19:35,040,506...35,066,571
JBrowse link
G IFNG interferon gamma multiple interactions ISO
EXP
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG protein
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA
CTD PMID:15588918 PMID:29594315 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IFNGR1 interferon gamma receptor 1 increases expression EXP Pentamidine results in increased expression of IFNGR1 mRNA; Pentamidine results in increased expression of IFNGR1 protein CTD PMID:12803856 NCBI chr 6:137,197,484...137,220,351
Ensembl chr 6:137,197,484...137,219,449
Ensembl chr 6:137,197,484...137,219,449
JBrowse link
G IL10 interleukin 10 multiple interactions
decreases expression
ISO [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL10 protein
Pentamidine results in decreased expression of IL10 protein
CTD PMID:15588918 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL1B interleukin 1 beta decreases expression EXP Pentamidine results in decreased expression of IL1B mRNA CTD PMID:29594315 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL2 interleukin 2 multiple interactions ISO
EXP
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 protein
[Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA
CTD PMID:15588918 PMID:29594315 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL4 interleukin 4 multiple interactions ISO [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL4 protein CTD PMID:15588918 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G INHBE inhibin subunit beta E increases expression EXP Pentamidine results in increased expression of INHBE mRNA CTD PMID:15342952 NCBI chr12:57,455,307...57,458,025
Ensembl chr12:57,452,323...57,459,280
JBrowse link
G KAT5 lysine acetyltransferase 5 multiple interactions
decreases activity
EXP Pentamidine inhibits the reaction [KAT5 protein results in increased acetylation of TP53 protein]
Pentamidine results in decreased activity of KAT5 protein
CTD PMID:20144237 NCBI chr11:65,712,018...65,719,604
Ensembl chr11:65,711,996...65,719,604
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
EXP Pentamidine affects the localization of and affects the activity of KCNH2 protein; Pentamidine affects the localization of and results in decreased activity of KCNH2 protein; Pentamidine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Pentamidine results in decreased activity of KCNH2 protein
CTD PMID:15340016 PMID:15711590 PMID:21158687 NCBI chr 7:150,944,956...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G LSS lanosterol synthase decreases expression EXP Pentamidine results in decreased expression of LSS mRNA CTD PMID:15342952 NCBI chr21:46,188,446...46,228,774
Ensembl chr21:46,188,141...46,228,824
JBrowse link
G MRE11 MRE11 homolog, double strand break repair nuclease decreases activity EXP Pentamidine results in decreased activity of MRE11 protein CTD PMID:20144237 NCBI chr11:94,415,570...94,512,701
Ensembl chr11:94,415,578...94,493,908
Ensembl chr11:94,415,578...94,493,908
JBrowse link
G NBN nibrin affects localization EXP Pentamidine affects the localization of NBN protein CTD PMID:20144237 NCBI chr 8:89,933,331...89,984,698
Ensembl chr 8:89,933,336...90,003,228
Ensembl chr 8:89,933,336...90,003,228
JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 increases expression EXP Pentamidine results in increased expression of NR0B2 mRNA CTD PMID:15342952 NCBI chr 1:26,911,489...26,914,110
Ensembl chr 1:26,911,489...26,913,975
JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 increases activity EXP Pentamidine results in increased activity of NR1H4 protein CTD PMID:22414727 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414
JBrowse link
G NUPR1 nuclear protein 1, transcriptional regulator increases expression EXP Pentamidine results in increased expression of NUPR1 mRNA CTD PMID:15342952 NCBI chr16:28,532,708...28,538,974
Ensembl chr16:28,532,708...28,539,174
Ensembl chr16:28,532,708...28,539,174
JBrowse link
G SERPINA3 serpin family A member 3 increases expression EXP Pentamidine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 NCBI chr14:94,612,391...94,624,053
Ensembl chr14:94,612,384...94,624,055
Ensembl chr14:94,612,384...94,624,055
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Pentamidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G SLC2A3 solute carrier family 2 member 3 decreases expression EXP Pentamidine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 NCBI chr12:7,919,230...7,936,187
Ensembl chr12:7,919,230...7,936,187
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP Pentamidine inhibits the reaction [KAT5 protein results in increased acetylation of TP53 protein] CTD PMID:20144237 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G WIPI1 WD repeat domain, phosphoinositide interacting 1 increases expression EXP Pentamidine results in increased expression of WIPI1 mRNA CTD PMID:15342952 NCBI chr17:68,421,281...68,457,496
Ensembl chr17:68,420,948...68,457,513
JBrowse link

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  CHEBI ontology 24370
    role 24278
      biological role 24245
        biochemical role 23626
          S100 calcium-binding protein B inhibitor 35
            pentamidine 35
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