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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:theaflavin
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Accession:CHEBI:136609 term browser browse the term
Definition:A biflavonoid that is 3,4,5-trihydroxybenzocyclohepten-6-one which is substituted at positions 1 and 8 by (2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl groups. It is the main red pigment in black tea.
Synonyms:exact_synonym: 3,4,5-trihydroxy-1,8-bis[(2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]-6H-benzocyclohepten-6-one
 related_synonym: 1,8-bis((2R,3R)-3,5,7-trihydroxy-2H-1-benzopyran-2-yl)-3,4,6-trihydroxy-5H-benzocyclohepten-5-one;   1,8-bis(3-alpha,5,7-trihydroxy-2-alpha-chromanyl)-5H-benzocyclohepten-5-one;   3,4,5-trihydroxy-1,8-bis[(2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]-6H-benzo[7]annulen-6-one;   Formula=C29H24O12;   InChI=1S/C29H24O12/c30-11-3-17(32)15-8-21(36)28(40-23(15)5-11)10-1-13-14(7-20(35)27(39)25(13)26(38)19(34)2-10)29-22(37)9-16-18(33)4-12(31)6-24(16)41-29/h1-7,21-22,28-33,35-37,39H,8-9H2,(H,34,38)/t21-,22-,28-,29-/m1/s1;   InChIKey=IPMYMEWFZKHGAX-ZKSIBHASSA-N;   SMILES=[C@@]1(OC=2C=C(O)C=C(O)C2C[C@H]1O)([H])C3=CC(=O)C(=C4C(=C3)C([C@]5(OC=6C=C(O)C=C(O)C6C[C@H]5O)[H])=CC(O)=C4O)O;   theaflavine
 xref: CAS:4670-05-7;   Chemspider:102754;   FooDB:FDB012511;   HMDB:HMDB0005788;   KNApSAcK:C00009348
 xref_mesh: MESH:C056068
 xref: PMID:26386739;   PMID:26851019;   PMID:27237789;   PMID:27756182;   PMID:27838465;   PMID:28190756;   PMID:28381812;   PMID:28639145;   PMID:28939421;   Patent:KR20080052675;   Reaxys:25497520;   Wikipedia:Theaflavin



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theaflavin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions EXP theaflavin inhibits the reaction [Tetrachlorodibenzodioxin binds to and affects the activity of AHR protein] CTD PMID:15914905 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Apc APC regulator of WNT signaling pathway multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of APC mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of APC protein] CTD PMID:27058323 NCBI chr18:26,138,382...26,196,021
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Apoe apolipoprotein E multiple interactions ISO theaflavin inhibits the reaction [APOE gene mutant form results in decreased activity of NOS3 protein]; theaflavin inhibits the reaction [APOE gene mutant form results in increased expression of PTGR1 protein]; theaflavin inhibits the reaction [APOE gene mutant form results in increased expression of SELP protein] CTD PMID:20093625 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of BCL2 mRNA] CTD PMID:18656336 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA] CTD PMID:27058323 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cd44 CD44 molecule multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CD44 protein] CTD PMID:27058323 NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of CDH1 mRNA] CTD PMID:27058323 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [theaflavin co-treated with Polylactic Acid-Polyglycolic Acid Copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CDKN1A mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CDKN1A mRNA] CTD PMID:23717041 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 protein] CTD PMID:27058323 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Egf epidermal growth factor multiple interactions ISO theaflavin inhibits the reaction [EGF protein results in increased expression of FAS mRNA]; theaflavin inhibits the reaction [EGF protein results in increased expression of FAS protein] CTD PMID:12931129 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO
EXP
theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of EGFR mRNA]
[theaflavin co-treated with theaflavine gallate co-treated with theaflavin-3,3'-digallate] inhibits the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased phosphorylation of EGFR protein]; [theaflavin co-treated with theaflavine gallate co-treated with theaflavin-3,3'-digallate] inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EGFR mRNA]
CTD PMID:21475988 PMID:27058323 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit multiple interactions ISO [theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ERCC1 mRNA] CTD PMID:23717041 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO theaflavin inhibits the reaction [EGF protein results in increased expression of FAS mRNA]; theaflavin inhibits the reaction [EGF protein results in increased expression of FAS protein] CTD PMID:12931129 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO [theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of GADD45A mRNA] CTD PMID:23717041 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gli1 GLI family zinc finger 1 multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of GLI1 protein] CTD PMID:27058323 NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:63,156,926...63,169,251
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA]; theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of HRAS protein] CTD PMID:18656336 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Ins1 insulin 1 multiple interactions ISO theaflavin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]; theaflavin inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose] CTD PMID:18591783 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO [theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA] CTD PMID:23717041 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP [theaflavin co-treated with theaflavine gallate co-treated with theaflavin-3,3'-digallate] inhibits the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased phosphorylation of MUC5AC protein]; [theaflavin co-treated with theaflavine gallate co-treated with theaflavin-3,3'-digallate] inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC mRNA] CTD PMID:21475988 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO theaflavin inhibits the reaction [Benzo(a)pyrene results in increased expression of MYC mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of MYC mRNA] CTD PMID:18656336 PMID:27058323 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myh6 myosin heavy chain 6 increases expression ISO theaflavin results in increased expression of MYHC mRNA CTD PMID:32830510 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
JBrowse link
G Myod1 myogenic differentiation 1 increases expression ISO theaflavin results in increased expression of MYOD1 mRNA CTD PMID:32830510 NCBI chr 1:106,021,161...106,023,871
Ensembl chr 1:96,884,948...96,887,554
JBrowse link
G Myog myogenin increases expression ISO theaflavin results in increased expression of MYOG mRNA CTD PMID:32830510 NCBI chr13:48,297,476...48,300,065
Ensembl chr13:45,745,436...45,748,039
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO theaflavin inhibits the reaction [APOE gene mutant form results in decreased activity of NOS3 protein] CTD PMID:20093625 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions ISO theaflavin inhibits the reaction [APOE gene mutant form results in increased expression of PTGR1 protein] CTD PMID:20093625 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PTGS2 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PTGS2 mRNA] CTD PMID:23717041 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Selp selectin P multiple interactions ISO theaflavin inhibits the reaction [APOE gene mutant form results in increased expression of SELP protein] CTD PMID:20093625 NCBI chr13:79,009,379...79,044,994
Ensembl chr13:76,476,295...76,511,845
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of SFRP1 mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of SFRP1 protein] CTD PMID:27058323 NCBI chr16:75,278,325...75,316,736
Ensembl chr16:68,575,763...68,614,286
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO theaflavin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein] CTD PMID:18591783 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Smo smoothened, frizzled class receptor multiple interactions ISO theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of SMO mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of SMO protein] CTD PMID:27058323 NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:58,343,529...58,373,829
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TRP53 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TRP53 mRNA]; theaflavin promotes the reaction [Benzo(a)pyrene results in increased expression of TRP53 mRNA] CTD PMID:18656336 PMID:23717041 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions ISO [theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC1 mRNA] CTD PMID:23717041 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
JBrowse link
G Xrcc3 X-ray repair cross complementing 3 multiple interactions ISO [theaflavin co-treated with Polylactic Acid-Polyglycolic Acid Copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC3 mRNA]; theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of XRCC3 mRNA] CTD PMID:23717041 NCBI chr 6:136,684,558...136,694,822
Ensembl chr 6:130,863,959...130,872,444
JBrowse link

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  CHEBI ontology 20856
    role 20816
      chemical role 20394
        antioxidant 16461
          theaflavin 33
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  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            organic molecule 20649
                              organic cyclic compound 20400
                                organic heterocyclic compound 19383
                                  oxacycle 18292
                                    benzopyran 12079
                                      1-benzopyran 11825
                                        flavonoid oligomer 209
                                          biflavonoid 160
                                            theaflavin 33
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