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ONTOLOGY REPORT - ANNOTATIONS


Term:ethylisopropylamiloride
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Accession:CHEBI:136538 term browser browse the term
Definition:A member of the class of pyrazines that is amiloride in which the amino substitutent of the pyrazine ring that is adjacent to the chloro substituent has been substituted by an ethyl group and by an isopropyl group.
Synonyms:exact_synonym: 3-amino-N-carbamimidoyl-6-chloro-5-[ethyl(isopropyl)amino]pyrazine-2-carboxamide
 related_synonym: 3-amino-N-(aminoiminomethyl)-6-chloro-5-(ethyl(1-methylethyl)amino)pyrazinecarboxamide;   5-(N-ethyl-N-isopropyl)amiloride;   5-(ethylisopropyl)amiloride;   EIPA;   Formula=C11H18ClN7O;   InChI=1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20);   InChIKey=QDERNBXNXJCIQK-UHFFFAOYSA-N;   N-amidino-3-amino-5-ethylisopropylamino-6-chloropyrazine carboxamide;   SMILES=C=1(C(=NC(=C(N1)Cl)N(C(C)C)CC)N)C(NC(N)=N)=O;   ethyl isopropyl amiloride
 xref: CAS:1154-25-2 "ChemIDplus"
 xref_mesh: MESH:C039614
 xref: PMID:10482815 "Europe PMC";   PMID:12897821 "Europe PMC";   PMID:15968466 "Europe PMC";   PMID:20338684 "Europe PMC";   PMID:23075671 "Europe PMC";   PMID:23864606 "Europe PMC";   PMID:25985899 "Europe PMC";   PMID:26547075 "Europe PMC";   PMID:9486355 "Europe PMC"


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ethylisopropylamiloride term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:6480464
G Aoc1 amine oxidase, copper containing 1 JBrowse link 4 78,496,043 78,515,582 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 6 2,308,179 2,316,739 RGD:6480464
G Fah fumarylacetoacetate hydrolase JBrowse link 1 146,713,663 146,736,339 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Slc9a1 solute carrier family 9 member A1 JBrowse link 5 151,573,122 151,626,360 RGD:6480464
G Srsf3 serine and arginine rich splicing factor 3 JBrowse link 20 6,288,285 6,298,218 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pharmaceutical 19097
          drug 19097
            diuretic 967
              amiloride 80
                ethylisopropylamiloride 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        carboacyl group 16943
                                          univalent carboacyl group 16943
                                            carbamoyl group 16622
                                              carboxamide 16622
                                                monocarboxylic acid amide 13180
                                                  ethylisopropylamiloride 17
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