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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ethylisopropylamiloride
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Accession:CHEBI:136538 term browser browse the term
Definition:A member of the class of pyrazines that is amiloride in which the amino substitutent of the pyrazine ring that is adjacent to the chloro substituent has been substituted by an ethyl group and by an isopropyl group.
Synonyms:exact_synonym: 3-amino-N-carbamimidoyl-6-chloro-5-[ethyl(isopropyl)amino]pyrazine-2-carboxamide
 related_synonym: 3-amino-N-(aminoiminomethyl)-6-chloro-5-(ethyl(1-methylethyl)amino)pyrazinecarboxamide;   5-(N-ethyl-N-isopropyl)amiloride;   5-(ethylisopropyl)amiloride;   EIPA;   Formula=C11H18ClN7O;   InChI=1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20);   InChIKey=QDERNBXNXJCIQK-UHFFFAOYSA-N;   N-amidino-3-amino-5-ethylisopropylamino-6-chloropyrazine carboxamide;   SMILES=C=1(C(=NC(=C(N1)Cl)N(C(C)C)CC)N)C(NC(N)=N)=O;   ethyl isopropyl amiloride
 xref: CAS:1154-25-2
 xref_mesh: MESH:C039614
 xref: PMID:10482815;   PMID:12897821;   PMID:15968466;   PMID:20338684;   PMID:23075671;   PMID:23864606;   PMID:25985899;   PMID:26547075;   PMID:9486355

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ethylisopropylamiloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin decreases uptake ISO ethylisopropylamiloride results in decreased uptake of ALB protein CTD PMID:16313995 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Aoc1 amine oxidase, copper containing 1 affects binding
multiple interactions
decreases activity		 ISO ethylisopropylamiloride binds to AOC1 protein
ethylisopropylamiloride inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]
ethylisopropylamiloride results in decreased activity of AOC1 protein		 CTD PMID:2217167, PMID:8144586 NCBI chr 4:78,496,043...78,515,582
Ensembl chr 4:78,496,043...78,515,584 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO ethylisopropylamiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein] CTD PMID:12107048 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP ethylisopropylamiloride inhibits the reaction [ferric nitrilotriacetate results in increased expression of COL1A1 protein]; ethylisopropylamiloride inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of COL1A1 protein] CTD PMID:11159895 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO ethylisopropylamiloride results in decreased activity of CYP1A1 protein CTD PMID:15081870 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO ethylisopropylamiloride results in decreased activity of CYP1A2 protein CTD PMID:15081870 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO ethylisopropylamiloride results in decreased activity of CYP1B1 protein CTD PMID:15081870 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Fah fumarylacetoacetate hydrolase affects splicing ISO ethylisopropylamiloride affects the splicing of FAH mutant form CTD PMID:23895425 NCBI chr 1:146,713,663...146,736,339
Ensembl chr 1:146,713,676...146,736,261 		JBrowse link
G Ifng interferon gamma multiple interactions ISO ethylisopropylamiloride inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with IFNG protein] results in increased secretion of IL12B protein] CTD PMID:11420121 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO ethylisopropylamiloride inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with IFNG protein] results in increased secretion of IL12B protein] CTD PMID:11420121 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO ethylisopropylamiloride inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein] CTD PMID:12065299 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO ethylisopropylamiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12107048 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO ethylisopropylamiloride inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:17237260 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO ethylisopropylamiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] CTD PMID:12107048 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 decreases activity
multiple interactions		 ISO
EXP		 ethylisopropylamiloride results in decreased activity of SLC9A1 protein
[ethylisopropylamiloride results in decreased activity of SLC9A1 protein] which results in increased abundance of Doxorubicin		 CTD PMID:12562776, PMID:15729714, PMID:17552965 NCBI chr 5:151,573,122...151,626,360
Ensembl chr 5:151,573,092...151,627,316 		JBrowse link
G Srsf3 serine and arginine rich splicing factor 3 increases expression ISO ethylisopropylamiloride results in increased expression of SRSF3 protein CTD PMID:17924536 NCBI chr20:6,288,285...6,298,218
Ensembl chr20:6,288,267...6,298,213 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO ethylisopropylamiloride results in decreased expression of VEGFA mRNA; ethylisopropylamiloride results in decreased expression of VEGFA protein CTD PMID:16884771 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            diuretic 1121
              amiloride 80
                ethylisopropylamiloride 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                monocarboxylic acid amide 14553
                                                  ethylisopropylamiloride 17
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