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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:otosenine
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Accession:CHEBI:136467 term browser browse the term
Definition:A pyrrolizine alkaloid that is produced by several Jacobaea and Senecio species.
Synonyms:exact_synonym: (1R,3'S,4S,6R,7R,11Z)-7-hydroxy-3',6,7,14-tetramethyl-3H,8H,17H-spiro[2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-4,2'-oxirane]-3,8,17-trione
 related_synonym: (-)-Octosenine;   Formula=C19H27NO7;   InChI=1S/C19H27NO7/c1-11-9-19(12(2)27-19)17(23)26-14-6-8-20(4)7-5-13(15(14)21)10-25-16(22)18(11,3)24/h5,11-12,14,24H,6-10H2,1-4H3/b13-5-/t11-,12+,14-,18-,19+/m1/s1;   InChIKey=CZQLULNMKQAIQL-GZSSMBGUSA-N;   Othosenin;   Othosenine;   SMILES=[C@@]12([C@H](C)O1)C(O[C@H]3C(C(=CCN(CC3)C)COC([C@]([C@@H](C2)C)(C)O)=O)=O)=O;   Tomentosine;   d-Otocenime;   d-Otosenine
 xref: AGR:IND605427552;   CAS:16958-29-5
 xref_mesh: MESH:C432462
 xref: PMID:11449528;   PMID:12182538;   PMID:17402047;   PMID:17404929;   PMID:17913058;   PMID:3210016;   PMID:4427963;   PMID:488324;   PMID:9581524;   Reaxys:4890096



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otosenine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G H2ax H2A.X variant histone increases expression ISO otosenine results in increased expression of H2AX protein CTD PMID:31154085 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      biological role 20000
        biochemical role 19624
          metabolite 19605
            alkaloid 5700
              pyrrolizine alkaloid 304
                otosenine 1
                  florosenine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            organic molecule 19809
                              organic cyclic compound 19572
                                organic heterocyclic compound 18799
                                  organic heteromonocyclic compound 17157
                                    saturated organic heteromonocyclic parent 9807
                                      oxirane 9778
                                        epoxide 9777
                                          spiro-epoxide 25
                                            otosenine 1
                                              florosenine 0
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