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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:erucifoline
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Accession:CHEBI:136462 term browser browse the term
Definition:A pyrrolizine alkaloid that is produced by several Jacobaea species and displays toxicity towards insect herbivores.
Synonyms:exact_synonym: (5aR,8Z,9aS,10aR,13bR)-8-ethylidene-9a-(hydroxymethyl)-10a-methyl-2,4,5,5a,8,9,9a,10a,13,13b-decahydrooxireno[8,9][1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-7,11-dione
 related_synonym: Formula=C18H23NO6;   InChI=1S/C18H23NO6/c1-3-11-8-18(10-20)17(2,25-18)16(22)23-9-12-4-6-19-7-5-13(14(12)19)24-15(11)21/h3-4,13-14,20H,5-10H2,1-2H3/b11-3-/t13-,14-,17+,18+/m1/s1;   InChIKey=NOQVBHHOUTTZGE-LUZNJDLOSA-N;   SMILES=C/1(\\C[C@]2(O[C@]2(C(=O)OCC3=CCN4CC[C@@H](OC1=O)[C@@]34[H])C)CO)=C/C
 xref: AGR:IND22014228;   CAS:40158-95-0;   Chemspider:57579891
 xref_mesh: MESH:C459639
 xref: PMID:11978435;   PMID:15081286;   PMID:21819407;   PMID:21969251;   PMID:24981118;   PMID:25607464;   PMID:28267991;   PMID:29377789;   Reaxys:5456751



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erucifoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G H2ax H2A.X variant histone increases expression ISO erucifoline results in increased expression of H2AX protein CTD PMID:31154085 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20039
    role 19990
      application 19729
        pesticide 17184
          insecticide 15259
            erucifoline 1
              acetylerucifoline 0
              acetylerucifoline N-oxide 0
              erucifoline N-oxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20039
    subatomic particle 20037
      composite particle 20037
        hadron 20037
          baryon 20037
            nucleon 20037
              atomic nucleus 20037
                atom 20037
                  main group element atom 19938
                    p-block element atom 19938
                      carbon group element atom 19861
                        carbon atom 19852
                          organic molecular entity 19852
                            organic molecule 19798
                              organic cyclic compound 19560
                                organic heterocyclic compound 18776
                                  organic heteropolycyclic compound 18245
                                    organic heterobicyclic compound 17128
                                      pyrrolizines 510
                                        pyrrolizine alkaloid 304
                                          senecionan 304
                                            erucifoline 1
                                              acetylerucifoline 0
                                              acetylerucifoline N-oxide 0
                                              erucifoline N-oxide 0
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