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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:VX nerve agent
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Accession:CHEBI:136185 term browser browse the term
Definition:A organic thiophosphate that is the ethyl ester of S-{2-[di(propan-2-yl)amino]ethyl} O hydrogen methylphosphonothioate. A toxic nerve agent used in chemical warfare.
Synonyms:exact_synonym: S-{2-[di(propan-2-yl)amino]ethyl} O-ethyl methylphosphonothioate
 related_synonym: Ethyl S-2-diisopropylaminoethyl methylphosphonothiolate;   Ethyl-S-diisopropylaminoethyl methylthiophosphonate;   Formula=C11H26NO2PS;   InChI=1S/C11H26NO2PS/c1-7-14-15(6,13)16-9-8-12(10(2)3)11(4)5/h10-11H,7-9H2,1-6H3;   InChIKey=JJIUCEJQJXNMHV-UHFFFAOYSA-N;   O-Ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate;   O-ethyl-S-[2-(N,N-diisopropylamino)ethyl] ester;   S-(2-Diisopropylaminoethyl) O-ethyl methyl phosphonothiolate;   SMILES=CC(N(CCSP(OCC)(=O)C)C(C)C)C;   VX
 xref: CAS:50782-69-9;   Chemspider:36386
 xref_mesh: MESH:C009680
 xref: PMID:20947456;   PMID:21862421;   PMID:21905719;   PMID:22042427;   PMID:23083335;   PMID:23126561;   PMID:23402290;   PMID:23872337;   PMID:24517492;   PMID:24633585;   PMID:24766293;   PMID:24854058;   PMID:24972874;   PMID:26327407;   PMID:26561750;   PMID:27113675;   PMID:27594690;   PMID:27627873;   PMID:28098192;   PMID:28179194;   PMID:28267914;   Reaxys:1949015;   Wikipedia:VX_(nerve_agent)


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VX nerve agent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity
multiple interactions
increases metabolic processing
decreases response to substance		 ISO
EXP		 VX analog results in decreased activity of ACHE protein; VX results in decreased activity of ACHE protein
4-amino-2-((diethylamino)methyl)phenol analog inhibits the reaction [VX results in decreased activity of ACHE protein]; ACHE protein mutant form promotes the reaction [asoxime chloride results in decreased susceptibility to VX]; asoxime chloride affects the reaction [VX results in decreased activity of ACHE protein]; asoxime chloride inhibits the reaction [VX results in decreased activity of ACHE protein]; benzohydroxamic acid analog inhibits the reaction [VX results in decreased activity of ACHE protein]; Cholinesterase Reactivators inhibits the reaction [VX binds to and results in decreased activity of ACHE protein]; Cholinesterase Reactivators inhibits the reaction [VX results in decreased activity of ACHE protein]; diacetylmonoxime inhibits the reaction [VX binds to and results in decreased activity of ACHE protein]; HLo 7 affects the reaction [VX results in decreased activity of ACHE protein]; isonitrosoacetone inhibits the reaction [VX binds to and results in decreased activity of ACHE protein]; isonitrosoacetone inhibits the reaction [VX results in decreased activity of ACHE protein]; N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [VX binds to and results in decreased activity of ACHE protein]; N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [VX results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [VX results in decreased activity of ACHE protein]; Oximes analog inhibits the reaction [VX results in decreased activity of ACHE protein]; Pralidoxime Compounds analog inhibits the reaction [VX results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [VX analog results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [VX binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [VX results in decreased activity of ACHE protein]; pralidoxime metabolite inhibits the reaction [VX results in decreased activity of ACHE protein]; pyridine-4-aldoxime analog inhibits the reaction [VX results in decreased activity of ACHE protein]; Pyridinium Compounds inhibits the reaction [VX results in decreased activity of ACHE protein]; pyridoxaloxime analog inhibits the reaction [VX results in decreased activity of ACHE protein]; RS194B analog inhibits the reaction [VX binds to and results in decreased activity of ACHE protein]; RS194B inhibits the reaction [VX binds to and results in decreased activity of ACHE protein]; RS41A inhibits the reaction [VX binds to and results in decreased activity of ACHE protein]; VX binds to and results in decreased activity of ACHE protein
VX results in increased metabolism of ACHE protein
ACHE results in decreased susceptibility to VX
1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene inhibits the reaction [VX results in decreased activity of ACHE protein]; [asoxime chloride co-treated with 1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene] inhibits the reaction [VX results in decreased activity of ACHE protein]; [asoxime chloride co-treated with Trimedoxime] inhibits the reaction [VX results in decreased activity of ACHE protein]; asoxime chloride inhibits the reaction [VX results in decreased activity of ACHE protein]; Trimedoxime inhibits the reaction [VX results in decreased activity of ACHE protein]; VX binds to and results in increased phosphorylation of and results in decreased activity of ACHE protein
1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene inhibits the reaction [VX results in decreased activity of ACHE protein]; [asoxime chloride co-treated with 1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene] inhibits the reaction [VX results in decreased activity of ACHE protein]; [asoxime chloride co-treated with Trimedoxime] inhibits the reaction [VX results in decreased activity of ACHE protein]; asoxime chloride inhibits the reaction [VX results in decreased activity of ACHE protein]; Cholinesterase Reactivators inhibits the reaction [VX analog results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [VX analog results in decreased activity of ACHE protein]; Pyridinium Compounds inhibits the reaction [VX analog results in decreased activity of ACHE protein]; Trimedoxime inhibits the reaction [VX analog results in decreased activity of ACHE protein]; Trimedoxime inhibits the reaction [VX results in decreased activity of ACHE protein]		 CTD PMID:1609424 PMID:12415428 PMID:14631503 PMID:16167316 PMID:17299830 More... NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation EXP VX results in increased phosphorylation of AKT1 protein CTD PMID:34653647 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bche butyrylcholinesterase decreases activity
multiple interactions		 ISO
EXP		 VX analog results in decreased activity of BCHE protein; VX metabolite results in decreased activity of BCHE protein; VX results in decreased activity of BCHE protein
[BCHE protein co-treated with asoxime chloride co-treated with pro-diazepam co-treated with Atropine] results in decreased susceptibility to VX; asoxime chloride inhibits the reaction [VX results in decreased activity of BCHE protein]; Obidoxime Chloride inhibits the reaction [VX results in decreased activity of BCHE protein]; Oximes analog inhibits the reaction [VX results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [VX analog results in decreased activity of BCHE protein]; pyridoxaloxime analog inhibits the reaction [VX results in decreased activity of BCHE protein]		 CTD PMID:17698511 PMID:18617161 PMID:19428953 PMID:22407886 PMID:22981459 More... NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression ISO VX results in increased expression of BDNF mRNA; VX results in increased expression of BDNF protein CTD PMID:22240983 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp3 caspase 3 increases activity EXP VX results in increased activity of CASP3 protein CTD PMID:34653647 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 decreases expression EXP VX results in decreased expression of CHRM2 protein CTD PMID:29127449 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Ddc dopa decarboxylase affects binding ISO VX binds to [DDC protein binds to Pyridoxal Phosphate]; VX binds to DDC protein CTD PMID:35151785 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Gad1 glutamate decarboxylase 1 affects binding ISO VX binds to [GAD1 protein binds to Pyridoxal Phosphate]; VX binds to GAD1 protein CTD PMID:35151785 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gad2 glutamate decarboxylase 2 affects binding ISO VX binds to [GAD2 protein binds to Pyridoxal Phosphate]; VX binds to GAD2 protein CTD PMID:35151785 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Hdc histidine decarboxylase affects binding ISO VX binds to [HDC protein binds to Pyridoxal Phosphate]; VX binds to HDC protein CTD PMID:35151785 NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases activity EXP VX results in decreased activity of IDH2 protein CTD PMID:28267914 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025 		JBrowse link
G Krt10 keratin 10 affects binding ISO VX binds to KRT10 protein CTD PMID:22521715 NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701 		JBrowse link
G Pepd peptidase D increases hydrolysis ISO PEPD protein results in increased hydrolysis of VX CTD PMID:22120822 NCBI chr 1:87,536,650...87,681,233
Ensembl chr 1:87,536,609...87,681,231 		JBrowse link
G Pon1 paraoxonase 1 decreases response to substance
increases hydrolysis		 ISO PON1 protein mutant form results in decreased susceptibility to VX
PON1 protein mutant form results in increased hydrolysis of VX; PON1 protein results in increased hydrolysis of VX		 CTD PMID:20176005 PMID:23159884 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 EXP VX results in increased expression of PTGS2 mRNA; VX results in increased expression of PTGS2 protein
[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased susceptibility to VX		 CTD PMID:22306367 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression EXP VX results in decreased expression of VEGFA protein CTD PMID:34653647 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
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  CHEBI ontology 19818
    role 19790
      biological role 19788
        aetiopathogenetic role 19148
          neurotoxin 18047
            VX nerve agent 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      chalcogen 19548
                        oxygen atom 19524
                          oxygen molecular entity 19524
                            hydroxides 19312
                              oxoacid 18688
                                pnictogen oxoacid 11811
                                  phosphorus oxoacid 10786
                                    phosphoric acids 9770
                                      phosphoric acid 9770
                                        phosphoric acid derivative 9514
                                          phosphate 9512
                                            organic phosphate 9512
                                              organic thiophosphate 5891
                                                VX nerve agent 16
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