CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: linsidomine
Accession: CHEBI:136004
browse the term
Synonyms: related_synonym: Formula=C6H10N4O2; InChI=1S/C6H10N4O2/c7-6-5-10(8-12-6)9-1-3-11-4-2-9/h5,7H,1-4H2; InChIKey=FKDHHVKWGRFRTG-UHFFFAOYSA-N; SMILES=C1CN(CCO1)[N+]2=CC(O[N-]2)=N; linsidomine HCl; linsidomine hydrochloride
xref: CAS:33876-97-0; Drug_Central:4589
xref_mesh: MESH:C002385
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Abca5
ATP binding cassette subfamily A member 5
increases oxidation
EXP
linsidomine results in increased oxidation of ABCA5 protein
CTD
PMID:28086193
NCBI chr10:98,573,226...98,645,028
Ensembl chr10:98,576,039...98,644,938
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Acp5
acid phosphatase 5, tartrate resistant
increases oxidation
EXP
linsidomine results in increased oxidation of ACP5 protein
CTD
PMID:28086193
NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
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Agrn
agrin
increases oxidation
EXP
linsidomine results in increased oxidation of AGRN protein
CTD
PMID:28086193
NCBI chr 5:173,589,910...173,622,813
Ensembl chr 5:173,589,819...173,622,645
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Akt1
AKT serine/threonine kinase 1
increases metabolic processing increases phosphorylation multiple interactions
ISO EXP
linsidomine results in increased metabolism of AKT1 protein linsidomine results in increased phosphorylation of AKT1 protein wortmannin inhibits the reaction [linsidomine results in increased phosphorylation of AKT1 protein] linsidomine inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]
CTD
PMID:17302912 PMID:19682478
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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Ap2a2
adaptor related protein complex 2 subunit alpha 2
increases oxidation
EXP
linsidomine results in increased oxidation of AP2A2 protein
CTD
PMID:28086193
NCBI chr 1:214,534,217...214,607,497
Ensembl chr 1:214,534,284...214,606,169
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Apba1
amyloid beta precursor protein binding family A member 1
increases oxidation
EXP
linsidomine results in increased oxidation of APBA1 protein
CTD
PMID:28086193
NCBI chr 1:241,594,565...241,796,512
Ensembl chr 1:241,594,565...241,796,513
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Apob
apolipoprotein B
increases oxidation
EXP
linsidomine results in increased oxidation of APOB protein
CTD
PMID:28086193
NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
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Arnt2
aryl hydrocarbon receptor nuclear translocator 2
increases oxidation
EXP
linsidomine results in increased oxidation of ARNT2 protein
CTD
PMID:28086193
NCBI chr 1:146,399,217...146,556,437
Ensembl chr 1:146,399,217...146,556,171
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Atf4
activating transcription factor 4
increases expression
ISO
linsidomine results in increased expression of ATF4 mRNA
CTD
PMID:21703327
NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
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Avp
arginine vasopressin
increases expression
EXP
linsidomine results in increased expression of AVP mRNA
CTD
PMID:10460269
NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
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Avpr1b
arginine vasopressin receptor 1B
increases oxidation
EXP
linsidomine results in increased oxidation of AVPR1B protein
CTD
PMID:28086193
NCBI chr13:48,367,307...48,378,831
Ensembl chr13:48,367,307...48,378,831
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Bax
BCL2 associated X, apoptosis regulator
increases expression multiple interactions
ISO
linsidomine results in increased expression of BAX Selegiline inhibits the reaction [linsidomine results in increased expression of BAX protein] MT1A inhibits the reaction [linsidomine results in increased expression of BAX]
CTD
PMID:12880480 PMID:16291239
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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Bcl2
BCL2, apoptosis regulator
decreases expression multiple interactions
ISO
linsidomine results in decreased expression of BCL2; linsidomine results in decreased expression of BCL2 protein [linsidomine results in increased abundance of Nitric Oxide] which results in increased expression of BCL2 mRNA; [linsidomine results in increased abundance of Nitric Oxide] which results in increased expression of BCL2 protein; Selegiline inhibits the reaction [linsidomine results in decreased expression of BCL2 protein] MT1A inhibits the reaction [linsidomine results in decreased expression of BCL2]; Plant Extracts inhibits the reaction [linsidomine results in decreased expression of BCL2 protein]
CTD
PMID:7706495 PMID:12880480 PMID:16291239 PMID:23174672
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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Brca2
BRCA2, DNA repair associated
increases oxidation
EXP
linsidomine results in increased oxidation of BRCA2 protein
CTD
PMID:28086193
NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
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Cacna1c
calcium voltage-gated channel subunit alpha1 C
multiple interactions
ISO
[linsidomine co-treated with Peroxynitrous Acid] results in increased nitrosation of CACNA1C protein
CTD
PMID:17551092
NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
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Cacna1e
calcium voltage-gated channel subunit alpha1 E
increases oxidation
EXP
linsidomine results in increased oxidation of CACNA1E protein
CTD
PMID:28086193
NCBI chr13:71,899,445...72,534,992
Ensembl chr13:71,906,702...72,367,980
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Cacna1h
calcium voltage-gated channel subunit alpha1 H
increases oxidation
EXP
linsidomine results in increased oxidation of CACNA1H protein
CTD
PMID:28086193
NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617
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Cacnb2
calcium voltage-gated channel auxiliary subunit beta 2
increases oxidation
EXP
linsidomine results in increased oxidation of CACNB2 protein
CTD
PMID:28086193
NCBI chr17:81,673,862...82,019,219
Ensembl chr17:81,798,756...82,017,682
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Calca
calcitonin-related polypeptide alpha
increases response to substance
EXP
CALCA protein results in increased susceptibility to linsidomine
CTD
PMID:8581270
NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
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Carm1
coactivator-associated arginine methyltransferase 1
increases oxidation
EXP
linsidomine results in increased oxidation of CARM1 protein
CTD
PMID:28086193
NCBI chr 8:22,577,723...22,622,555
Ensembl chr 8:22,577,715...22,622,560
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Casp3
caspase 3
increases activity multiple interactions increases expression increases cleavage
ISO EXP
linsidomine results in increased activity of CASP3 protein Melatonin inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA]; MT1A inhibits the reaction [linsidomine results in increased activity of CASP3 protein]; Plant Extracts inhibits the reaction [linsidomine results in increased cleavage of CASP3 protein]; Plant Extracts inhibits the reaction [linsidomine results in increased expression of CASP3 protein modified form]; Selegiline inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA]; Selegiline inhibits the reaction [linsidomine results in increased expression of CASP3 protein]; Ubiquinone inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA] linsidomine results in increased expression of CASP3 mRNA; linsidomine results in increased expression of CASP3 protein; linsidomine results in increased expression of CASP3 protein modified form
CTD
PMID:12880480 PMID:15686499 PMID:16291239 PMID:19038279 PMID:23174672
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Cat
catalase
multiple interactions
ISO
linsidomine results in decreased activity of and results in decreased expression of CAT protein; Plant Extracts inhibits the reaction [linsidomine results in decreased activity of and results in decreased expression of CAT protein] CAT protein inhibits the reaction [linsidomine results in decreased expression of CCND1 mRNA]; CAT protein inhibits the reaction [linsidomine results in decreased expression of CCND1 protein]
CTD
PMID:12600834 PMID:23174672
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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Ccnd1
cyclin D1
multiple interactions decreases expression
ISO
CAT protein inhibits the reaction [linsidomine results in decreased expression of CCND1 mRNA]; CAT protein inhibits the reaction [linsidomine results in decreased expression of CCND1 protein] linsidomine results in decreased expression of CCND1 mRNA; linsidomine results in decreased expression of CCND1 protein
CTD
PMID:12600834
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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Cep83
centrosomal protein 83
increases oxidation
EXP
linsidomine results in increased oxidation of CEP83 protein
CTD
PMID:28086193
NCBI chr 7:35,739,553...35,847,618
Ensembl chr 7:35,773,928...35,847,617
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Cep95
centrosomal protein 95
increases oxidation
EXP
linsidomine results in increased oxidation of CEP95 protein
CTD
PMID:28086193
NCBI chr10:94,988,362...95,017,774
Ensembl chr10:94,988,362...95,016,344
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Clrn1
clarin 1
increases oxidation
EXP
linsidomine results in increased oxidation of CLRN1 protein
CTD
PMID:28086193
NCBI chr 2:149,049,925...149,088,787
Ensembl chr 2:149,049,925...149,088,787
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Clu
clusterin
increases oxidation
EXP
linsidomine results in increased oxidation of CLU protein
CTD
PMID:28086193
NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
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Crh
corticotropin releasing hormone
multiple interactions increases expression
EXP
CRH protein affects the reaction [linsidomine results in increased secretion of POMC protein alternative form] linsidomine results in increased expression of CRH mRNA
CTD
PMID:10460269
NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
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Crhr1
corticotropin releasing hormone receptor 1
increases expression
EXP
linsidomine results in increased expression of CRHR1 mRNA
CTD
PMID:10460269
NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645
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Cttnbp2
cortactin binding protein 2
increases oxidation
EXP
linsidomine results in increased oxidation of CTTNBP2 protein
CTD
PMID:28086193
NCBI chr 4:42,932,897...43,096,454
Ensembl chr 4:42,932,903...43,096,399
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Cycs
cytochrome c, somatic
affects localization multiple interactions
ISO
linsidomine affects the localization of CYCS protein Selegiline inhibits the reaction [linsidomine affects the localization of CYCS protein]
CTD
PMID:12880480
NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
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Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
linsidomine results in increased expression of DDIT3 mRNA
CTD
PMID:21703327
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
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Ddx52
DExD-box helicase 52
increases oxidation
EXP
linsidomine results in increased oxidation of DDX52 protein
CTD
PMID:28086193
NCBI chr10:71,253,667...71,276,397
Ensembl chr10:71,253,598...71,277,277
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Dlgap4
DLG associated protein 4
increases oxidation
EXP
linsidomine results in increased oxidation of DLGAP4 protein
CTD
PMID:28086193
NCBI chr 3:152,752,091...152,846,118
Ensembl chr 3:152,752,091...152,846,118
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Dnah7
dynein, axonemal, heavy chain 7
increases oxidation
EXP
linsidomine results in increased oxidation of DNAH7 protein
CTD
PMID:28086193
NCBI chr 9:60,070,087...60,330,121 NCBI chr 9:59,564,253...59,595,347
Ensembl chr 9:60,070,739...60,330,125 Ensembl chr 9:60,070,739...60,330,125
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Dnmt1
DNA methyltransferase 1
increases oxidation
EXP
linsidomine results in increased oxidation of DNMT1 protein
CTD
PMID:28086193
NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
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Dscam
DS cell adhesion molecule
increases oxidation
EXP
linsidomine results in increased oxidation of DSCAM protein
CTD
PMID:28086193
NCBI chr11:37,004,776...37,599,866
Ensembl chr11:37,004,902...37,253,776
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E2f2
E2F transcription factor 2
decreases activity
ISO
linsidomine results in decreased activity of E2F2 protein
CTD
PMID:12600834
NCBI chr 5:154,516,611...154,540,228
Ensembl chr 5:154,522,119...154,540,265
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Eaf2
ELL associated factor 2
increases oxidation
EXP
linsidomine results in increased oxidation of EAF2 protein
CTD
PMID:28086193
NCBI chr11:66,878,658...66,923,092
Ensembl chr11:66,878,658...66,923,092
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Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
increases phosphorylation
ISO
linsidomine results in increased phosphorylation of EIF2AK3 protein
CTD
PMID:21703327
NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
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Eif2s1
eukaryotic translation initiation factor 2 subunit alpha
increases phosphorylation
ISO
linsidomine results in increased phosphorylation of EIF2S1 protein
CTD
PMID:21703327
NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
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Ephx2
epoxide hydrolase 2
increases oxidation
EXP
linsidomine results in increased oxidation of EPHX2 protein
CTD
PMID:28086193
NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
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Evl
Enah/Vasp-like
increases oxidation
EXP
linsidomine results in increased oxidation of EVL protein
CTD
PMID:28086193
NCBI chr 6:132,470,283...132,590,242
Ensembl chr 6:132,510,757...132,590,241
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Fam221b
family with sequence similarity 221, member B
increases oxidation
EXP
linsidomine results in increased oxidation of FAM221B protein
CTD
PMID:28086193
NCBI chr 5:59,156,079...59,165,440
Ensembl chr 5:59,156,071...59,165,160
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Faslg
Fas ligand
multiple interactions
ISO
[linsidomine results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [linsidomine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of FASLG promoter]
CTD
PMID:10811113
NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
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Fasn
fatty acid synthase
increases oxidation
EXP
linsidomine results in increased oxidation of FASN protein
CTD
PMID:28086193
NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
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Fra10ac1
FRA10A associated CGG repeat 1
increases oxidation
EXP
linsidomine results in increased oxidation of FRA10AC1 protein
CTD
PMID:28086193
NCBI chr 1:256,881,688...256,913,617
Ensembl chr 1:256,881,771...256,914,260
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Gabra5
gamma-aminobutyric acid type A receptor subunit alpha 5
increases oxidation
EXP
linsidomine results in increased oxidation of GABRA5 protein
CTD
PMID:28086193
NCBI chr 1:112,833,941...112,947,482
Ensembl chr 1:112,833,944...112,947,451
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Glg1
golgi glycoprotein 1
increases oxidation
EXP
linsidomine results in increased oxidation of GLG1 protein
CTD
PMID:28086193
NCBI chr19:42,983,879...43,088,074
Ensembl chr19:42,983,869...43,090,841
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Golga4
golgin A4
increases oxidation
EXP
linsidomine results in increased oxidation of GOLGA4 protein
CTD
PMID:28086193
NCBI chr 8:127,171,221...127,248,938
Ensembl chr 8:127,171,537...127,248,538
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Grm7
glutamate metabotropic receptor 7
increases oxidation
EXP
linsidomine results in increased oxidation of GRM7 protein
CTD
PMID:28086193
NCBI chr 4:142,452,616...143,368,460
Ensembl chr 4:142,780,987...143,367,578
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Gsta2
glutathione S-transferase alpha 2
increases expression
EXP
linsidomine results in increased expression of GSTA2; linsidomine results in increased expression of GSTA2 protein
CTD
PMID:12446173 PMID:15357004
NCBI chr 8:85,640,081...85,645,621
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Gucy2d
guanylate cyclase 2D, retinal
increases oxidation
EXP
linsidomine results in increased oxidation of GUCY2E protein
CTD
PMID:28086193
NCBI chr10:55,835,695...55,851,235
Ensembl chr10:55,835,695...55,851,235
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Hadha
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
increases oxidation
EXP
linsidomine results in increased oxidation of HADHA protein
CTD
PMID:28086193
NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175
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Hgs
hepatocyte growth factor-regulated tyrosine kinase substrate
increases oxidation
EXP
linsidomine results in increased oxidation of HGS protein
CTD
PMID:28086193
NCBI chr10:109,638,944...109,657,460
Ensembl chr10:109,638,767...109,657,456
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Hist1h2bg
histone cluster 1, H2bg
increases oxidation
EXP
linsidomine results in increased oxidation of HIST1H2BG protein
CTD
PMID:28086193
NCBI chr17:43,817,316...43,817,717
Ensembl chr17:43,817,378...43,817,720
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Hmox1
heme oxygenase 1
multiple interactions increases expression
ISO
[linsidomine co-treated with Nitroprusside] results in increased expression of HMOX1 mRNA; [linsidomine co-treated with S-Nitrosoglutathione] results in increased expression of HMOX1 mRNA linsidomine results in increased expression of HMOX1 mRNA
CTD
PMID:8764571 PMID:10423162
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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Hnrnpm
heterogeneous nuclear ribonucleoprotein M
increases oxidation
EXP
linsidomine results in increased oxidation of HNRNPM protein
CTD
PMID:28086193
NCBI chr 7:18,516,253...18,554,536
Ensembl chr 7:18,516,512...18,554,227
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Hormad1
HORMA domain containing 1
increases oxidation
EXP
linsidomine results in increased oxidation of HORMAD1 protein
CTD
PMID:28086193
NCBI chr 2:197,681,820...197,720,197
Ensembl chr 2:197,682,000...197,719,254
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Il6
interleukin 6
multiple interactions increases secretion
ISO
TLR4 gene mutant form inhibits the reaction [linsidomine results in increased secretion of IL6 protein]
CTD
PMID:29175419
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Ilk
integrin-linked kinase
increases oxidation
EXP
linsidomine results in increased oxidation of ILK protein
CTD
PMID:28086193
NCBI chr 1:170,578,941...170,585,192
Ensembl chr 1:170,578,889...170,585,189
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Insr
insulin receptor
multiple interactions increases metabolic processing
ISO
linsidomine inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein] linsidomine results in increased metabolism of INSR protein
CTD
PMID:19682478
NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
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Iqsec3
IQ motif and Sec7 domain ArfGEF 3
increases oxidation
EXP
linsidomine results in increased oxidation of IQSEC3 protein
CTD
PMID:28086193
NCBI chr 4:153,948,052...154,044,493
Ensembl chr 4:153,948,055...154,044,493
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Irs1
insulin receptor substrate 1
multiple interactions
ISO
linsidomine inhibits the reaction [INS1 protein results in increased phosphorylation of IRS1 protein]; linsidomine results in increased metabolism of and results in decreased expression of IRS1 protein
CTD
PMID:19682478
NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
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Itpr1
inositol 1,4,5-trisphosphate receptor, type 1
multiple interactions increases expression
ISO
Cycloheximide inhibits the reaction [linsidomine results in increased expression of ITPR1 mRNA]; Dactinomycin inhibits the reaction [linsidomine results in increased expression of ITPR1 mRNA]
CTD
PMID:17241155
NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748
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Itpr3
inositol 1,4,5-trisphosphate receptor, type 3
increases oxidation
EXP
linsidomine results in increased oxidation of ITPR3 protein
CTD
PMID:28086193
NCBI chr20:5,645,894...5,711,702
Ensembl chr20:5,646,097...5,711,702
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Kat6a
lysine acetyltransferase 6A
increases oxidation
EXP
linsidomine results in increased oxidation of KAT6A protein
CTD
PMID:28086193
NCBI chr16:73,942,669...74,020,750
Ensembl chr16:73,943,455...74,023,005
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Keap1
Kelch-like ECH-associated protein 1
affects response to substance
ISO
KEAP1 mRNA affects the susceptibility to linsidomine
CTD
PMID:16092930
NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
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Khdrbs2
KH RNA binding domain containing, signal transduction associated 2
increases oxidation
EXP
linsidomine results in increased oxidation of KHDRBS2 protein
CTD
PMID:28086193
NCBI chr 9:39,501,431...40,008,707
Ensembl chr 9:39,539,530...40,008,680
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Klk8
kallikrein related-peptidase 8
increases oxidation
EXP
linsidomine results in increased oxidation of KLK8 protein
CTD
PMID:28086193
NCBI chr 1:99,735,168...99,742,011
Ensembl chr 1:99,734,993...99,742,009
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Mprip
myosin phosphatase Rho interacting protein
increases oxidation
EXP
linsidomine results in increased oxidation of MPRIP protein
CTD
PMID:28086193
NCBI chr10:46,018,397...46,133,580
Ensembl chr10:46,018,659...46,133,571
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Mt1
metallothionein 1
multiple interactions decreases response to substance increases expression
ISO
MT1A inhibits the reaction [linsidomine results in decreased expression of BCL2]; MT1A inhibits the reaction [linsidomine results in increased activity of CASP3 protein]; MT1A inhibits the reaction [linsidomine results in increased expression of BAX] Selegiline inhibits the reaction [linsidomine results in increased expression of MT1 protein] MT1 protein results in decreased susceptibility to linsidomine
CTD
PMID:12880480 PMID:16291239
NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
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Mtfr1
mitochondrial fission regulator 1
increases oxidation
EXP
linsidomine results in increased oxidation of MTFR1 protein
CTD
PMID:28086193
NCBI chr 2:104,005,696...104,040,914
Ensembl chr 2:104,020,955...104,039,198
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Mtor
mechanistic target of rapamycin kinase
increases oxidation
EXP
linsidomine results in increased oxidation of MTOR protein
CTD
PMID:28086193
NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
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Mybpc3
myosin binding protein C3
increases oxidation
EXP
linsidomine results in increased oxidation of MYBPC3 protein
CTD
PMID:28086193
NCBI chr 3:79,940,509...79,958,731
Ensembl chr 3:79,940,561...79,958,730
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Nat1
N-acetyltransferase 1
decreases activity
ISO
linsidomine results in decreased activity of NAT1 protein
CTD
PMID:14672957
NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573
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Nbr1
NBR1, autophagy cargo receptor
increases oxidation
EXP
linsidomine results in increased oxidation of NBR1 protein
CTD
PMID:28086193
NCBI chr10:89,455,202...89,483,791
Ensembl chr10:89,459,650...89,484,080
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Nf1
neurofibromin 1
increases oxidation
EXP
linsidomine results in increased oxidation of NF1 protein
CTD
PMID:28086193
NCBI chr10:66,732,460...66,928,706
Ensembl chr10:66,690,133...66,928,903
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Nfe2l2
nuclear factor, erythroid 2-like 2
multiple interactions decreases response to substance
ISO EXP
[linsidomine results in increased expression of NFE2L2 protein] which results in decreased susceptibility to Oxidopamine linsidomine results in increased localization of and results in increased activity of NFE2L2 protein NFE2L2 results in decreased susceptibility to linsidomine 1,2-dithiol-3-thione promotes the reaction [NFE2L2 results in decreased susceptibility to linsidomine] NFE2L2 protein results in decreased susceptibility to linsidomine
CTD
PMID:12446173 PMID:16092930 PMID:18367636
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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Nos1
nitric oxide synthase 1
increases expression increases oxidation
EXP
linsidomine results in increased expression of NOS1 mRNA linsidomine results in increased oxidation of NOS1 protein
CTD
PMID:19038279 PMID:28086193
NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
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Nos2
nitric oxide synthase 2
increases expression multiple interactions
ISO
linsidomine results in increased expression of NOS2 protein [linsidomine results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites; [Plant Extracts inhibits the reaction [linsidomine results in increased expression of NOS2 protein]] which results in decreased chemical synthesis of Nitrites; Plant Extracts inhibits the reaction [linsidomine results in increased expression of NOS2 protein]
CTD
PMID:23174672
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
increases expression
EXP
linsidomine results in increased expression of NR4A1 mRNA
CTD
PMID:10460269
NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
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Oma1
OMA1 zinc metallopeptidase
increases oxidation
EXP
linsidomine results in increased oxidation of OMA1 protein
CTD
PMID:28086193
NCBI chr 5:122,847,624...122,900,475
Ensembl chr 5:122,847,645...122,900,475
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions decreases expression
ISO
Selegiline inhibits the reaction [linsidomine results in decreased expression of PARP1 protein]
CTD
PMID:12880480
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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Pcna
proliferating cell nuclear antigen
decreases expression
ISO
linsidomine results in decreased expression of PCNA protein
CTD
PMID:12600834
NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
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Pds5a
PDS5 cohesin associated factor A
increases oxidation
EXP
linsidomine results in increased oxidation of PDS5A protein
CTD
PMID:28086193
NCBI chr14:44,185,445...44,282,308
Ensembl chr14:44,185,446...44,280,079
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Pepd
peptidase D
multiple interactions
ISO
linsidomine results in increased phosphorylation of and results in increased activity of PEPD protein
CTD
PMID:16167338
NCBI chr 1:90,820,670...91,285,128
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Per2
period circadian regulator 2
decreases response to substance
ISO
PER2 protein mutant form results in decreased susceptibility to linsidomine
CTD
PMID:25628599
NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
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Pi4ka
phosphatidylinositol 4-kinase alpha
increases oxidation
EXP
linsidomine results in increased oxidation of PI4KA protein
CTD
PMID:28086193
NCBI chr11:87,858,323...87,975,549
Ensembl chr11:87,858,453...87,973,422
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Pif1
PIF1 5'-to-3' DNA helicase
increases oxidation
EXP
linsidomine results in increased oxidation of PIF1 protein
CTD
PMID:28086193
NCBI chr 8:71,124,477...71,133,460
Ensembl chr 8:71,125,414...71,132,629
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Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
multiple interactions
ISO
linsidomine inhibits the reaction [INS1 protein binds to PIK3R1 protein]; linsidomine inhibits the reaction [INS1 protein results in increased activity of PIK3R1 protein]
CTD
PMID:19682478
NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
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Plb1
phospholipase B1
increases oxidation
EXP
linsidomine results in increased oxidation of PLB1 protein
CTD
PMID:28086193
NCBI chr 6:25,375,699...25,507,108
Ensembl chr 6:25,397,537...25,507,073
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Plekhg5
pleckstrin homology and RhoGEF domain containing G5
increases oxidation
EXP
linsidomine results in increased oxidation of PLEKHG5 protein
CTD
PMID:28086193
NCBI chr 5:169,244,778...169,288,310
Ensembl chr 5:169,244,778...169,288,309
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Pomc
proopiomelanocortin
multiple interactions increases secretion
EXP
CRH protein affects the reaction [linsidomine results in increased secretion of POMC protein alternative form]
CTD
PMID:10460269
NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
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Ppp1r37
protein phosphatase 1, regulatory subunit 37
increases oxidation
EXP
linsidomine results in increased oxidation of PPP1R37 protein
CTD
PMID:28086193
NCBI chr 1:80,439,718...80,471,527
Ensembl chr 1:80,439,718...80,471,527
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Prkca
protein kinase C, alpha
multiple interactions
EXP
[linsidomine co-treated with Staurosporine] results in decreased expression of PRKCA protein; Staurosporine inhibits the reaction [linsidomine results in increased phosphorylation of PRKCA protein]
CTD
PMID:11994256
NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
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Prkn
parkin RBR E3 ubiquitin protein ligase
increases expression multiple interactions
ISO
linsidomine results in increased expression of PRKN protein Selegiline inhibits the reaction [linsidomine results in increased expression of PRKN protein]
CTD
PMID:12880480
NCBI chr 1:48,880,015...50,069,998
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Pten
phosphatase and tensin homolog
increases oxidation
EXP
linsidomine results in increased oxidation of PTEN protein
CTD
PMID:17302912
NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
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Rab29
RAB29, member RAS oncogene family
increases oxidation
EXP
linsidomine results in increased oxidation of RAB29 protein
CTD
PMID:28086193
NCBI chr13:48,644,575...48,650,229
Ensembl chr13:48,644,604...48,650,220
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Ran
RAN, member RAS oncogene family
increases oxidation
EXP
linsidomine results in increased oxidation of RAN protein
CTD
PMID:28086193
NCBI chr12:31,319,556...31,324,105
Ensembl chr12:31,320,624...31,323,810
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Rb1
RB transcriptional corepressor 1
decreases phosphorylation
ISO
linsidomine results in decreased phosphorylation of RB1 protein
CTD
PMID:12600834
NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [linsidomine affects the activity of RELA protein]; linsidomine affects the localization of and affects the activity of RELA protein
CTD
PMID:29175419
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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Rexo5
RNA exonuclease 5
increases oxidation
EXP
linsidomine results in increased oxidation of REXO5 protein
CTD
PMID:28086193
NCBI chr 1:189,549,960...189,643,698
Ensembl chr 1:189,549,960...189,622,094
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Ryr2
ryanodine receptor 2
increases oxidation
EXP
linsidomine results in increased oxidation of RYR2 protein
CTD
PMID:28086193
NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
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Sclt1
sodium channel and clathrin linker 1
increases oxidation
EXP
linsidomine results in increased oxidation of SCLT1 protein
CTD
PMID:28086193
NCBI chr 2:128,523,376...128,675,668
Ensembl chr 2:128,523,636...128,675,408
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Scn8a
sodium voltage-gated channel alpha subunit 8
increases oxidation
EXP
linsidomine results in increased oxidation of SCN8A protein
CTD
PMID:28086193
NCBI chr 7:142,575,629...142,683,659
Ensembl chr 7:142,575,672...142,684,114
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Secisbp2
SECIS binding protein 2
increases oxidation
EXP
linsidomine results in increased oxidation of SECISBP2 protein
CTD
PMID:28086193
NCBI chr17:13,555,348...13,586,595
Ensembl chr17:13,555,349...13,586,554
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Sfrp4
secreted frizzled-related protein 4
increases oxidation
EXP
linsidomine results in increased oxidation of SFRP4 protein
CTD
PMID:28086193
NCBI chr17:47,383,983...47,394,065
Ensembl chr17:47,297,489...47,394,328
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Slc12a2
solute carrier family 12 member 2
multiple interactions increases activity
EXP
linsidomine results in increased phosphorylation of and results in increased expression of SLC12A2 protein linsidomine results in increased activity of SLC12A2 protein
CTD
PMID:25817889
NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
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Smc1a
structural maintenance of chromosomes 1A
increases oxidation
EXP
linsidomine results in increased oxidation of SMC1A protein
CTD
PMID:28086193
NCBI chr X:21,710,976...21,755,708
Ensembl chr X:21,711,019...21,755,525
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Snca
synuclein alpha
increases expression multiple interactions
ISO
linsidomine results in increased expression of SNCA protein Selegiline inhibits the reaction [linsidomine results in increased expression of SNCA protein]
CTD
PMID:12880480
NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
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Sod1
superoxide dismutase 1
multiple interactions
ISO
linsidomine results in decreased activity of and results in decreased expression of SOD1 protein; Plant Extracts inhibits the reaction [linsidomine results in decreased activity of and results in decreased expression of SOD1 protein]
CTD
PMID:23174672
NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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Sod2
superoxide dismutase 2
multiple interactions increases response to substance increases expression
ISO
Acetylcysteine inhibits the reaction [linsidomine results in increased expression of SOD2 mRNA]; Cysteine inhibits the reaction [linsidomine results in increased expression of SOD2 mRNA] SOD2 protein results in increased susceptibility to linsidomine
CTD
PMID:9741582 PMID:10511315
NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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Speg
striated muscle enriched protein kinase
increases oxidation
EXP
linsidomine results in increased oxidation of SPEG protein
CTD
PMID:28086193
NCBI chr 9:82,571,333...82,628,684
Ensembl chr 9:82,571,269...82,628,709
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Svep1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
increases oxidation
EXP
linsidomine results in increased oxidation of SVEP1 protein
CTD
PMID:28086193
NCBI chr 5:75,147,245...75,320,873
Ensembl chr 5:75,143,867...75,319,765
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Synrg
synergin, gamma
increases oxidation
EXP
linsidomine results in increased oxidation of SYNRG protein
CTD
PMID:28086193
NCBI chr10:71,278,698...71,357,791
G
Sytl4
synaptotagmin-like 4
increases oxidation
EXP
linsidomine results in increased oxidation of SYTL4 protein
CTD
PMID:28086193
NCBI chr X:104,763,961...104,814,152
Ensembl chr X:104,765,294...104,814,145
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Tgfb1
transforming growth factor, beta 1
multiple interactions increases activity decreases expression
EXP
2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [linsidomine results in decreased expression of TGFB1 mRNA]; 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [linsidomine results in decreased expression of TGFB1 protein] linsidomine results in increased activity of TGFB1 protein linsidomine results in decreased expression of TGFB1 mRNA; linsidomine results in decreased expression of TGFB1 protein
CTD
PMID:11994256
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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Tlr4
toll-like receptor 4
multiple interactions
ISO
TLR4 gene mutant form inhibits the reaction [linsidomine results in increased secretion of IL6 protein]; TLR4 gene mutant form inhibits the reaction [linsidomine results in increased secretion of TNF protein]
CTD
PMID:29175419
NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
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Tnf
tumor necrosis factor
increases secretion multiple interactions
ISO
linsidomine results in increased secretion of TNF protein TLR4 gene mutant form inhibits the reaction [linsidomine results in increased secretion of TNF protein]
CTD
PMID:29175419
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Trim40
tripartite motif-containing 40
increases oxidation
EXP
linsidomine results in increased oxidation of TRIM40 protein
CTD
PMID:28086193
NCBI chr20:2,169,674...2,178,477
Ensembl chr20:2,169,545...2,178,601
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Trpm1
transient receptor potential cation channel, subfamily M, member 1
increases oxidation
EXP
linsidomine results in increased oxidation of TRPM1 protein
CTD
PMID:28086193
NCBI chr 1:124,983,391...125,101,759
Ensembl chr 1:124,983,452...125,099,573
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Trpm7
transient receptor potential cation channel, subfamily M, member 7
increases oxidation
EXP
linsidomine results in increased oxidation of TRPM7 protein
CTD
PMID:28086193
NCBI chr 3:119,258,189...119,347,084
Ensembl chr 3:119,259,467...119,330,345
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Unc13a
unc-13 homolog A
increases oxidation
EXP
linsidomine results in increased oxidation of UNC13A protein
CTD
PMID:28086193
NCBI chr16:20,056,398...20,103,951
Ensembl chr16:20,056,765...20,097,287
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Vgf
VGF nerve growth factor inducible
increases oxidation
EXP
linsidomine results in increased oxidation of VGF protein
CTD
PMID:28086193
NCBI chr12:22,677,302...22,680,630
Ensembl chr12:22,677,607...22,680,630
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Vim
vimentin
increases oxidation
EXP
linsidomine results in increased oxidation of VIM protein
CTD
PMID:28086193
NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
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Wdr7
WD repeat domain 7
increases oxidation
EXP
linsidomine results in increased oxidation of WDR7 protein
CTD
PMID:28086193
NCBI chr18:59,096,636...59,396,312
Ensembl chr18:59,096,643...59,396,318
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Whrn
whirlin
increases oxidation
EXP
linsidomine results in increased oxidation of WHRN protein
CTD
PMID:28086193
NCBI chr 5:79,235,541...79,317,206
Ensembl chr 5:79,234,950...79,317,206
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Ythdc1
YTH domain containing 1
increases oxidation
EXP
linsidomine results in increased oxidation of YTHDC1 protein
CTD
PMID:28086193
NCBI chr14:22,971,834...23,002,326
Ensembl chr14:22,971,836...23,002,011
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Zfp148
zinc finger protein 148
increases oxidation
EXP
linsidomine results in increased oxidation of ZFP148 protein
CTD
PMID:28086193
NCBI chr11:70,509,909...70,618,422
Ensembl chr11:70,514,750...70,618,347
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Zfp518a
zinc finger protein 518A
increases oxidation
EXP
linsidomine results in increased oxidation of ZFP518A protein
CTD
PMID:28086193
NCBI chr 1:260,152,881...260,178,360
Ensembl chr 1:260,153,645...260,178,349
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