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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:linsidomine
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Accession:CHEBI:136004 term browser browse the term
Synonyms:related_synonym: Formula=C6H10N4O2;   InChI=1S/C6H10N4O2/c7-6-5-10(8-12-6)9-1-3-11-4-2-9/h5,7H,1-4H2;   InChIKey=FKDHHVKWGRFRTG-UHFFFAOYSA-N;   SMILES=C1CN(CCO1)[N+]2=CC(O[N-]2)=N;   linsidomine HCl;   linsidomine hydrochloride
 xref: CAS:33876-97-0;   Drug_Central:4589
 xref_mesh: MESH:C002385

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linsidomine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca5 ATP binding cassette subfamily A member 5 increases oxidation EXP linsidomine results in increased oxidation of ABCA5 protein CTD PMID:28086193 NCBI chr10:98,573,226...98,645,028
Ensembl chr10:98,576,039...98,644,938 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant increases oxidation EXP linsidomine results in increased oxidation of ACP5 protein CTD PMID:28086193 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396 		JBrowse link
G Agrn agrin increases oxidation EXP linsidomine results in increased oxidation of AGRN protein CTD PMID:28086193 NCBI chr 5:173,589,910...173,622,813
Ensembl chr 5:173,589,819...173,622,645 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases metabolic processing
increases phosphorylation
multiple interactions		 ISO
EXP		 linsidomine results in increased metabolism of AKT1 protein
linsidomine results in increased phosphorylation of AKT1 protein
wortmannin inhibits the reaction [linsidomine results in increased phosphorylation of AKT1 protein]
linsidomine inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]		 CTD PMID:17302912 PMID:19682478 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Ap2a2 adaptor related protein complex 2 subunit alpha 2 increases oxidation EXP linsidomine results in increased oxidation of AP2A2 protein CTD PMID:28086193 NCBI chr 1:214,534,217...214,607,497
Ensembl chr 1:214,534,284...214,606,169 		JBrowse link
G Apba1 amyloid beta precursor protein binding family A member 1 increases oxidation EXP linsidomine results in increased oxidation of APBA1 protein CTD PMID:28086193 NCBI chr 1:241,594,565...241,796,512
Ensembl chr 1:241,594,565...241,796,513 		JBrowse link
G Apob apolipoprotein B increases oxidation EXP linsidomine results in increased oxidation of APOB protein CTD PMID:28086193 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997 		JBrowse link
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 increases oxidation EXP linsidomine results in increased oxidation of ARNT2 protein CTD PMID:28086193 NCBI chr 1:146,399,217...146,556,437
Ensembl chr 1:146,399,217...146,556,171 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO linsidomine results in increased expression of ATF4 mRNA CTD PMID:21703327 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772 		JBrowse link
G Avp arginine vasopressin increases expression EXP linsidomine results in increased expression of AVP mRNA CTD PMID:10460269 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460 		JBrowse link
G Avpr1b arginine vasopressin receptor 1B increases oxidation EXP linsidomine results in increased oxidation of AVPR1B protein CTD PMID:28086193 NCBI chr13:48,367,307...48,378,831
Ensembl chr13:48,367,307...48,378,831 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO linsidomine results in increased expression of BAX
Selegiline inhibits the reaction [linsidomine results in increased expression of BAX protein]
MT1A inhibits the reaction [linsidomine results in increased expression of BAX]		 CTD PMID:12880480 PMID:16291239 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO linsidomine results in decreased expression of BCL2; linsidomine results in decreased expression of BCL2 protein
[linsidomine results in increased abundance of Nitric Oxide] which results in increased expression of BCL2 mRNA; [linsidomine results in increased abundance of Nitric Oxide] which results in increased expression of BCL2 protein; Selegiline inhibits the reaction [linsidomine results in decreased expression of BCL2 protein]
MT1A inhibits the reaction [linsidomine results in decreased expression of BCL2]; Plant Extracts inhibits the reaction [linsidomine results in decreased expression of BCL2 protein]		 CTD PMID:7706495 PMID:12880480 PMID:16291239 PMID:23174672 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Brca2 BRCA2, DNA repair associated increases oxidation EXP linsidomine results in increased oxidation of BRCA2 protein CTD PMID:28086193 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions ISO [linsidomine co-treated with Peroxynitrous Acid] results in increased nitrosation of CACNA1C protein CTD PMID:17551092 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913 		JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E increases oxidation EXP linsidomine results in increased oxidation of CACNA1E protein CTD PMID:28086193 NCBI chr13:71,899,445...72,534,992
Ensembl chr13:71,906,702...72,367,980 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H increases oxidation EXP linsidomine results in increased oxidation of CACNA1H protein CTD PMID:28086193 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617 		JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 increases oxidation EXP linsidomine results in increased oxidation of CACNB2 protein CTD PMID:28086193 NCBI chr17:81,673,862...82,019,219
Ensembl chr17:81,798,756...82,017,682 		JBrowse link
G Calca calcitonin-related polypeptide alpha increases response to substance EXP CALCA protein results in increased susceptibility to linsidomine CTD PMID:8581270 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911 		JBrowse link
G Carm1 coactivator-associated arginine methyltransferase 1 increases oxidation EXP linsidomine results in increased oxidation of CARM1 protein CTD PMID:28086193 NCBI chr 8:22,577,723...22,622,555
Ensembl chr 8:22,577,715...22,622,560 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases expression
increases cleavage		 ISO
EXP		 linsidomine results in increased activity of CASP3 protein
Melatonin inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA]; MT1A inhibits the reaction [linsidomine results in increased activity of CASP3 protein]; Plant Extracts inhibits the reaction [linsidomine results in increased cleavage of CASP3 protein]; Plant Extracts inhibits the reaction [linsidomine results in increased expression of CASP3 protein modified form]; Selegiline inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA]; Selegiline inhibits the reaction [linsidomine results in increased expression of CASP3 protein]; Ubiquinone inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA]
linsidomine results in increased expression of CASP3 mRNA; linsidomine results in increased expression of CASP3 protein; linsidomine results in increased expression of CASP3 protein modified form		 CTD PMID:12880480 PMID:15686499 PMID:16291239 PMID:19038279 PMID:23174672 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cat catalase multiple interactions ISO linsidomine results in decreased activity of and results in decreased expression of CAT protein; Plant Extracts inhibits the reaction [linsidomine results in decreased activity of and results in decreased expression of CAT protein]
CAT protein inhibits the reaction [linsidomine results in decreased expression of CCND1 mRNA]; CAT protein inhibits the reaction [linsidomine results in decreased expression of CCND1 protein]		 CTD PMID:12600834 PMID:23174672 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 ISO CAT protein inhibits the reaction [linsidomine results in decreased expression of CCND1 mRNA]; CAT protein inhibits the reaction [linsidomine results in decreased expression of CCND1 protein]
linsidomine results in decreased expression of CCND1 mRNA; linsidomine results in decreased expression of CCND1 protein		 CTD PMID:12600834 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cep83 centrosomal protein 83 increases oxidation EXP linsidomine results in increased oxidation of CEP83 protein CTD PMID:28086193 NCBI chr 7:35,739,553...35,847,618
Ensembl chr 7:35,773,928...35,847,617 		JBrowse link
G Cep95 centrosomal protein 95 increases oxidation EXP linsidomine results in increased oxidation of CEP95 protein CTD PMID:28086193 NCBI chr10:94,988,362...95,017,774
Ensembl chr10:94,988,362...95,016,344 		JBrowse link
G Clrn1 clarin 1 increases oxidation EXP linsidomine results in increased oxidation of CLRN1 protein CTD PMID:28086193 NCBI chr 2:149,049,925...149,088,787
Ensembl chr 2:149,049,925...149,088,787 		JBrowse link
G Clu clusterin increases oxidation EXP linsidomine results in increased oxidation of CLU protein CTD PMID:28086193 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857 		JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases expression		 EXP CRH protein affects the reaction [linsidomine results in increased secretion of POMC protein alternative form]
linsidomine results in increased expression of CRH mRNA		 CTD PMID:10460269 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 increases expression EXP linsidomine results in increased expression of CRHR1 mRNA CTD PMID:10460269 NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645 		JBrowse link
G Cttnbp2 cortactin binding protein 2 increases oxidation EXP linsidomine results in increased oxidation of CTTNBP2 protein CTD PMID:28086193 NCBI chr 4:42,932,897...43,096,454
Ensembl chr 4:42,932,903...43,096,399 		JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions		 ISO linsidomine affects the localization of CYCS protein
Selegiline inhibits the reaction [linsidomine affects the localization of CYCS protein]		 CTD PMID:12880480 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO linsidomine results in increased expression of DDIT3 mRNA CTD PMID:21703327 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Ddx52 DExD-box helicase 52 increases oxidation EXP linsidomine results in increased oxidation of DDX52 protein CTD PMID:28086193 NCBI chr10:71,253,667...71,276,397
Ensembl chr10:71,253,598...71,277,277 		JBrowse link
G Dlgap4 DLG associated protein 4 increases oxidation EXP linsidomine results in increased oxidation of DLGAP4 protein CTD PMID:28086193 NCBI chr 3:152,752,091...152,846,118
Ensembl chr 3:152,752,091...152,846,118 		JBrowse link
G Dnah7 dynein, axonemal, heavy chain 7 increases oxidation EXP linsidomine results in increased oxidation of DNAH7 protein CTD PMID:28086193 NCBI chr 9:60,070,087...60,330,121
NCBI chr 9:59,564,253...59,595,347
Ensembl chr 9:60,070,739...60,330,125
Ensembl chr 9:60,070,739...60,330,125 		JBrowse link
G Dnmt1 DNA methyltransferase 1 increases oxidation EXP linsidomine results in increased oxidation of DNMT1 protein CTD PMID:28086193 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495 		JBrowse link
G Dscam DS cell adhesion molecule increases oxidation EXP linsidomine results in increased oxidation of DSCAM protein CTD PMID:28086193 NCBI chr11:37,004,776...37,599,866
Ensembl chr11:37,004,902...37,253,776 		JBrowse link
G E2f2 E2F transcription factor 2 decreases activity ISO linsidomine results in decreased activity of E2F2 protein CTD PMID:12600834 NCBI chr 5:154,516,611...154,540,228
Ensembl chr 5:154,522,119...154,540,265 		JBrowse link
G Eaf2 ELL associated factor 2 increases oxidation EXP linsidomine results in increased oxidation of EAF2 protein CTD PMID:28086193 NCBI chr11:66,878,658...66,923,092
Ensembl chr11:66,878,658...66,923,092 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation ISO linsidomine results in increased phosphorylation of EIF2AK3 protein CTD PMID:21703327 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO linsidomine results in increased phosphorylation of EIF2S1 protein CTD PMID:21703327 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041 		JBrowse link
G Ephx2 epoxide hydrolase 2 increases oxidation EXP linsidomine results in increased oxidation of EPHX2 protein CTD PMID:28086193 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279 		JBrowse link
G Evl Enah/Vasp-like increases oxidation EXP linsidomine results in increased oxidation of EVL protein CTD PMID:28086193 NCBI chr 6:132,470,283...132,590,242
Ensembl chr 6:132,510,757...132,590,241 		JBrowse link
G Fam221b family with sequence similarity 221, member B increases oxidation EXP linsidomine results in increased oxidation of FAM221B protein CTD PMID:28086193 NCBI chr 5:59,156,079...59,165,440
Ensembl chr 5:59,156,071...59,165,160 		JBrowse link
G Faslg Fas ligand multiple interactions ISO [linsidomine results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [linsidomine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of FASLG promoter] CTD PMID:10811113 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Fasn fatty acid synthase increases oxidation EXP linsidomine results in increased oxidation of FASN protein CTD PMID:28086193 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Fra10ac1 FRA10A associated CGG repeat 1 increases oxidation EXP linsidomine results in increased oxidation of FRA10AC1 protein CTD PMID:28086193 NCBI chr 1:256,881,688...256,913,617
Ensembl chr 1:256,881,771...256,914,260 		JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 increases oxidation EXP linsidomine results in increased oxidation of GABRA5 protein CTD PMID:28086193 NCBI chr 1:112,833,941...112,947,482
Ensembl chr 1:112,833,944...112,947,451 		JBrowse link
G Glg1 golgi glycoprotein 1 increases oxidation EXP linsidomine results in increased oxidation of GLG1 protein CTD PMID:28086193 NCBI chr19:42,983,879...43,088,074
Ensembl chr19:42,983,869...43,090,841 		JBrowse link
G Golga4 golgin A4 increases oxidation EXP linsidomine results in increased oxidation of GOLGA4 protein CTD PMID:28086193 NCBI chr 8:127,171,221...127,248,938
Ensembl chr 8:127,171,537...127,248,538 		JBrowse link
G Grm7 glutamate metabotropic receptor 7 increases oxidation EXP linsidomine results in increased oxidation of GRM7 protein CTD PMID:28086193 NCBI chr 4:142,452,616...143,368,460
Ensembl chr 4:142,780,987...143,367,578 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP linsidomine results in increased expression of GSTA2; linsidomine results in increased expression of GSTA2 protein CTD PMID:12446173 PMID:15357004 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gucy2d guanylate cyclase 2D, retinal increases oxidation EXP linsidomine results in increased oxidation of GUCY2E protein CTD PMID:28086193 NCBI chr10:55,835,695...55,851,235
Ensembl chr10:55,835,695...55,851,235 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha increases oxidation EXP linsidomine results in increased oxidation of HADHA protein CTD PMID:28086193 NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175 		JBrowse link
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate increases oxidation EXP linsidomine results in increased oxidation of HGS protein CTD PMID:28086193 NCBI chr10:109,638,944...109,657,460
Ensembl chr10:109,638,767...109,657,456 		JBrowse link
G Hist1h2bg histone cluster 1, H2bg increases oxidation EXP linsidomine results in increased oxidation of HIST1H2BG protein CTD PMID:28086193 NCBI chr17:43,817,316...43,817,717
Ensembl chr17:43,817,378...43,817,720 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO [linsidomine co-treated with Nitroprusside] results in increased expression of HMOX1 mRNA; [linsidomine co-treated with S-Nitrosoglutathione] results in increased expression of HMOX1 mRNA
linsidomine results in increased expression of HMOX1 mRNA		 CTD PMID:8764571 PMID:10423162 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hnrnpm heterogeneous nuclear ribonucleoprotein M increases oxidation EXP linsidomine results in increased oxidation of HNRNPM protein CTD PMID:28086193 NCBI chr 7:18,516,253...18,554,536
Ensembl chr 7:18,516,512...18,554,227 		JBrowse link
G Hormad1 HORMA domain containing 1 increases oxidation EXP linsidomine results in increased oxidation of HORMAD1 protein CTD PMID:28086193 NCBI chr 2:197,681,820...197,720,197
Ensembl chr 2:197,682,000...197,719,254 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion		 ISO TLR4 gene mutant form inhibits the reaction [linsidomine results in increased secretion of IL6 protein] CTD PMID:29175419 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Ilk integrin-linked kinase increases oxidation EXP linsidomine results in increased oxidation of ILK protein CTD PMID:28086193 NCBI chr 1:170,578,941...170,585,192
Ensembl chr 1:170,578,889...170,585,189 		JBrowse link
G Insr insulin receptor multiple interactions
increases metabolic processing		 ISO linsidomine inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]
linsidomine results in increased metabolism of INSR protein		 CTD PMID:19682478 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414 		JBrowse link
G Iqsec3 IQ motif and Sec7 domain ArfGEF 3 increases oxidation EXP linsidomine results in increased oxidation of IQSEC3 protein CTD PMID:28086193 NCBI chr 4:153,948,052...154,044,493
Ensembl chr 4:153,948,055...154,044,493 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO linsidomine inhibits the reaction [INS1 protein results in increased phosphorylation of IRS1 protein]; linsidomine results in increased metabolism of and results in decreased expression of IRS1 protein CTD PMID:19682478 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions
increases expression		 ISO Cycloheximide inhibits the reaction [linsidomine results in increased expression of ITPR1 mRNA]; Dactinomycin inhibits the reaction [linsidomine results in increased expression of ITPR1 mRNA] CTD PMID:17241155 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748 		JBrowse link
G Itpr3 inositol 1,4,5-trisphosphate receptor, type 3 increases oxidation EXP linsidomine results in increased oxidation of ITPR3 protein CTD PMID:28086193 NCBI chr20:5,645,894...5,711,702
Ensembl chr20:5,646,097...5,711,702 		JBrowse link
G Kat6a lysine acetyltransferase 6A increases oxidation EXP linsidomine results in increased oxidation of KAT6A protein CTD PMID:28086193 NCBI chr16:73,942,669...74,020,750
Ensembl chr16:73,943,455...74,023,005 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 affects response to substance ISO KEAP1 mRNA affects the susceptibility to linsidomine CTD PMID:16092930 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779 		JBrowse link
G Khdrbs2 KH RNA binding domain containing, signal transduction associated 2 increases oxidation EXP linsidomine results in increased oxidation of KHDRBS2 protein CTD PMID:28086193 NCBI chr 9:39,501,431...40,008,707
Ensembl chr 9:39,539,530...40,008,680 		JBrowse link
G Klk8 kallikrein related-peptidase 8 increases oxidation EXP linsidomine results in increased oxidation of KLK8 protein CTD PMID:28086193 NCBI chr 1:99,735,168...99,742,011
Ensembl chr 1:99,734,993...99,742,009 		JBrowse link
G Mprip myosin phosphatase Rho interacting protein increases oxidation EXP linsidomine results in increased oxidation of MPRIP protein CTD PMID:28086193 NCBI chr10:46,018,397...46,133,580
Ensembl chr10:46,018,659...46,133,571 		JBrowse link
G Mt1 metallothionein 1 multiple interactions
decreases response to substance
increases expression		 ISO MT1A inhibits the reaction [linsidomine results in decreased expression of BCL2]; MT1A inhibits the reaction [linsidomine results in increased activity of CASP3 protein]; MT1A inhibits the reaction [linsidomine results in increased expression of BAX]
Selegiline inhibits the reaction [linsidomine results in increased expression of MT1 protein]
MT1 protein results in decreased susceptibility to linsidomine		 CTD PMID:12880480 PMID:16291239 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724 		JBrowse link
G Mtfr1 mitochondrial fission regulator 1 increases oxidation EXP linsidomine results in increased oxidation of MTFR1 protein CTD PMID:28086193 NCBI chr 2:104,005,696...104,040,914
Ensembl chr 2:104,020,955...104,039,198 		JBrowse link
G Mtor mechanistic target of rapamycin kinase increases oxidation EXP linsidomine results in increased oxidation of MTOR protein CTD PMID:28086193 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Mybpc3 myosin binding protein C3 increases oxidation EXP linsidomine results in increased oxidation of MYBPC3 protein CTD PMID:28086193 NCBI chr 3:79,940,509...79,958,731
Ensembl chr 3:79,940,561...79,958,730 		JBrowse link
G Nat1 N-acetyltransferase 1 decreases activity ISO linsidomine results in decreased activity of NAT1 protein CTD PMID:14672957 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573 		JBrowse link
G Nbr1 NBR1, autophagy cargo receptor increases oxidation EXP linsidomine results in increased oxidation of NBR1 protein CTD PMID:28086193 NCBI chr10:89,455,202...89,483,791
Ensembl chr10:89,459,650...89,484,080 		JBrowse link
G Nf1 neurofibromin 1 increases oxidation EXP linsidomine results in increased oxidation of NF1 protein CTD PMID:28086193 NCBI chr10:66,732,460...66,928,706
Ensembl chr10:66,690,133...66,928,903 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
decreases response to substance		 ISO
EXP		 [linsidomine results in increased expression of NFE2L2 protein] which results in decreased susceptibility to Oxidopamine
linsidomine results in increased localization of and results in increased activity of NFE2L2 protein
NFE2L2 results in decreased susceptibility to linsidomine
1,2-dithiol-3-thione promotes the reaction [NFE2L2 results in decreased susceptibility to linsidomine]
NFE2L2 protein results in decreased susceptibility to linsidomine		 CTD PMID:12446173 PMID:16092930 PMID:18367636 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nos1 nitric oxide synthase 1 increases expression
increases oxidation		 EXP linsidomine results in increased expression of NOS1 mRNA
linsidomine results in increased oxidation of NOS1 protein		 CTD PMID:19038279 PMID:28086193 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions		 ISO linsidomine results in increased expression of NOS2 protein
[linsidomine results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites; [Plant Extracts inhibits the reaction [linsidomine results in increased expression of NOS2 protein]] which results in decreased chemical synthesis of Nitrites; Plant Extracts inhibits the reaction [linsidomine results in increased expression of NOS2 protein]		 CTD PMID:23174672 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression EXP linsidomine results in increased expression of NR4A1 mRNA CTD PMID:10460269 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216 		JBrowse link
G Oma1 OMA1 zinc metallopeptidase increases oxidation EXP linsidomine results in increased oxidation of OMA1 protein CTD PMID:28086193 NCBI chr 5:122,847,624...122,900,475
Ensembl chr 5:122,847,645...122,900,475 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
decreases expression		 ISO Selegiline inhibits the reaction [linsidomine results in decreased expression of PARP1 protein] CTD PMID:12880480 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO linsidomine results in decreased expression of PCNA protein CTD PMID:12600834 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Pds5a PDS5 cohesin associated factor A increases oxidation EXP linsidomine results in increased oxidation of PDS5A protein CTD PMID:28086193 NCBI chr14:44,185,445...44,282,308
Ensembl chr14:44,185,446...44,280,079 		JBrowse link
G Pepd peptidase D multiple interactions ISO linsidomine results in increased phosphorylation of and results in increased activity of PEPD protein CTD PMID:16167338 NCBI chr 1:90,820,670...91,285,128 JBrowse link
G Per2 period circadian regulator 2 decreases response to substance ISO PER2 protein mutant form results in decreased susceptibility to linsidomine CTD PMID:25628599 NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359 		JBrowse link
G Pi4ka phosphatidylinositol 4-kinase alpha increases oxidation EXP linsidomine results in increased oxidation of PI4KA protein CTD PMID:28086193 NCBI chr11:87,858,323...87,975,549
Ensembl chr11:87,858,453...87,973,422 		JBrowse link
G Pif1 PIF1 5'-to-3' DNA helicase increases oxidation EXP linsidomine results in increased oxidation of PIF1 protein CTD PMID:28086193 NCBI chr 8:71,124,477...71,133,460
Ensembl chr 8:71,125,414...71,132,629 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO linsidomine inhibits the reaction [INS1 protein binds to PIK3R1 protein]; linsidomine inhibits the reaction [INS1 protein results in increased activity of PIK3R1 protein] CTD PMID:19682478 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867 		JBrowse link
G Plb1 phospholipase B1 increases oxidation EXP linsidomine results in increased oxidation of PLB1 protein CTD PMID:28086193 NCBI chr 6:25,375,699...25,507,108
Ensembl chr 6:25,397,537...25,507,073 		JBrowse link
G Plekhg5 pleckstrin homology and RhoGEF domain containing G5 increases oxidation EXP linsidomine results in increased oxidation of PLEKHG5 protein CTD PMID:28086193 NCBI chr 5:169,244,778...169,288,310
Ensembl chr 5:169,244,778...169,288,309 		JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases secretion		 EXP CRH protein affects the reaction [linsidomine results in increased secretion of POMC protein alternative form] CTD PMID:10460269 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967 		JBrowse link
G Ppp1r37 protein phosphatase 1, regulatory subunit 37 increases oxidation EXP linsidomine results in increased oxidation of PPP1R37 protein CTD PMID:28086193 NCBI chr 1:80,439,718...80,471,527
Ensembl chr 1:80,439,718...80,471,527 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP [linsidomine co-treated with Staurosporine] results in decreased expression of PRKCA protein; Staurosporine inhibits the reaction [linsidomine results in increased phosphorylation of PRKCA protein] CTD PMID:11994256 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase increases expression
multiple interactions		 ISO linsidomine results in increased expression of PRKN protein
Selegiline inhibits the reaction [linsidomine results in increased expression of PRKN protein]		 CTD PMID:12880480 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Pten phosphatase and tensin homolog increases oxidation EXP linsidomine results in increased oxidation of PTEN protein CTD PMID:17302912 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832 		JBrowse link
G Rab29 RAB29, member RAS oncogene family increases oxidation EXP linsidomine results in increased oxidation of RAB29 protein CTD PMID:28086193 NCBI chr13:48,644,575...48,650,229
Ensembl chr13:48,644,604...48,650,220 		JBrowse link
G Ran RAN, member RAS oncogene family increases oxidation EXP linsidomine results in increased oxidation of RAN protein CTD PMID:28086193 NCBI chr12:31,319,556...31,324,105
Ensembl chr12:31,320,624...31,323,810 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO linsidomine results in decreased phosphorylation of RB1 protein CTD PMID:12600834 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [linsidomine affects the activity of RELA protein]; linsidomine affects the localization of and affects the activity of RELA protein CTD PMID:29175419 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Rexo5 RNA exonuclease 5 increases oxidation EXP linsidomine results in increased oxidation of REXO5 protein CTD PMID:28086193 NCBI chr 1:189,549,960...189,643,698
Ensembl chr 1:189,549,960...189,622,094 		JBrowse link
G Ryr2 ryanodine receptor 2 increases oxidation EXP linsidomine results in increased oxidation of RYR2 protein CTD PMID:28086193 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606 		JBrowse link
G Sclt1 sodium channel and clathrin linker 1 increases oxidation EXP linsidomine results in increased oxidation of SCLT1 protein CTD PMID:28086193 NCBI chr 2:128,523,376...128,675,668
Ensembl chr 2:128,523,636...128,675,408 		JBrowse link
G Scn8a sodium voltage-gated channel alpha subunit 8 increases oxidation EXP linsidomine results in increased oxidation of SCN8A protein CTD PMID:28086193 NCBI chr 7:142,575,629...142,683,659
Ensembl chr 7:142,575,672...142,684,114 		JBrowse link
G Secisbp2 SECIS binding protein 2 increases oxidation EXP linsidomine results in increased oxidation of SECISBP2 protein CTD PMID:28086193 NCBI chr17:13,555,348...13,586,595
Ensembl chr17:13,555,349...13,586,554 		JBrowse link
G Sfrp4 secreted frizzled-related protein 4 increases oxidation EXP linsidomine results in increased oxidation of SFRP4 protein CTD PMID:28086193 NCBI chr17:47,383,983...47,394,065
Ensembl chr17:47,297,489...47,394,328 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions
increases activity		 EXP linsidomine results in increased phosphorylation of and results in increased expression of SLC12A2 protein
linsidomine results in increased activity of SLC12A2 protein		 CTD PMID:25817889 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261 		JBrowse link
G Smc1a structural maintenance of chromosomes 1A increases oxidation EXP linsidomine results in increased oxidation of SMC1A protein CTD PMID:28086193 NCBI chr  X:21,710,976...21,755,708
Ensembl chr  X:21,711,019...21,755,525 		JBrowse link
G Snca synuclein alpha increases expression
multiple interactions		 ISO linsidomine results in increased expression of SNCA protein
Selegiline inhibits the reaction [linsidomine results in increased expression of SNCA protein]		 CTD PMID:12880480 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO linsidomine results in decreased activity of and results in decreased expression of SOD1 protein; Plant Extracts inhibits the reaction [linsidomine results in decreased activity of and results in decreased expression of SOD1 protein] CTD PMID:23174672 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases response to substance
increases expression		 ISO Acetylcysteine inhibits the reaction [linsidomine results in increased expression of SOD2 mRNA]; Cysteine inhibits the reaction [linsidomine results in increased expression of SOD2 mRNA]
SOD2 protein results in increased susceptibility to linsidomine		 CTD PMID:9741582 PMID:10511315 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Speg striated muscle enriched protein kinase increases oxidation EXP linsidomine results in increased oxidation of SPEG protein CTD PMID:28086193 NCBI chr 9:82,571,333...82,628,684
Ensembl chr 9:82,571,269...82,628,709 		JBrowse link
G Svep1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 increases oxidation EXP linsidomine results in increased oxidation of SVEP1 protein CTD PMID:28086193 NCBI chr 5:75,147,245...75,320,873
Ensembl chr 5:75,143,867...75,319,765 		JBrowse link
G Synrg synergin, gamma increases oxidation EXP linsidomine results in increased oxidation of SYNRG protein CTD PMID:28086193 NCBI chr10:71,278,698...71,357,791 JBrowse link
G Sytl4 synaptotagmin-like 4 increases oxidation EXP linsidomine results in increased oxidation of SYTL4 protein CTD PMID:28086193 NCBI chr  X:104,763,961...104,814,152
Ensembl chr  X:104,765,294...104,814,145 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases activity
decreases expression		 EXP 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [linsidomine results in decreased expression of TGFB1 mRNA]; 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [linsidomine results in decreased expression of TGFB1 protein]
linsidomine results in increased activity of TGFB1 protein
linsidomine results in decreased expression of TGFB1 mRNA; linsidomine results in decreased expression of TGFB1 protein		 CTD PMID:11994256 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO TLR4 gene mutant form inhibits the reaction [linsidomine results in increased secretion of IL6 protein]; TLR4 gene mutant form inhibits the reaction [linsidomine results in increased secretion of TNF protein] CTD PMID:29175419 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Tnf tumor necrosis factor increases secretion
multiple interactions		 ISO linsidomine results in increased secretion of TNF protein
TLR4 gene mutant form inhibits the reaction [linsidomine results in increased secretion of TNF protein]		 CTD PMID:29175419 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Trim40 tripartite motif-containing 40 increases oxidation EXP linsidomine results in increased oxidation of TRIM40 protein CTD PMID:28086193 NCBI chr20:2,169,674...2,178,477
Ensembl chr20:2,169,545...2,178,601 		JBrowse link
G Trpm1 transient receptor potential cation channel, subfamily M, member 1 increases oxidation EXP linsidomine results in increased oxidation of TRPM1 protein CTD PMID:28086193 NCBI chr 1:124,983,391...125,101,759
Ensembl chr 1:124,983,452...125,099,573 		JBrowse link
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 increases oxidation EXP linsidomine results in increased oxidation of TRPM7 protein CTD PMID:28086193 NCBI chr 3:119,258,189...119,347,084
Ensembl chr 3:119,259,467...119,330,345 		JBrowse link
G Unc13a unc-13 homolog A increases oxidation EXP linsidomine results in increased oxidation of UNC13A protein CTD PMID:28086193 NCBI chr16:20,056,398...20,103,951
Ensembl chr16:20,056,765...20,097,287 		JBrowse link
G Vgf VGF nerve growth factor inducible increases oxidation EXP linsidomine results in increased oxidation of VGF protein CTD PMID:28086193 NCBI chr12:22,677,302...22,680,630
Ensembl chr12:22,677,607...22,680,630 		JBrowse link
G Vim vimentin increases oxidation EXP linsidomine results in increased oxidation of VIM protein CTD PMID:28086193 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212 		JBrowse link
G Wdr7 WD repeat domain 7 increases oxidation EXP linsidomine results in increased oxidation of WDR7 protein CTD PMID:28086193 NCBI chr18:59,096,636...59,396,312
Ensembl chr18:59,096,643...59,396,318 		JBrowse link
G Whrn whirlin increases oxidation EXP linsidomine results in increased oxidation of WHRN protein CTD PMID:28086193 NCBI chr 5:79,235,541...79,317,206
Ensembl chr 5:79,234,950...79,317,206 		JBrowse link
G Ythdc1 YTH domain containing 1 increases oxidation EXP linsidomine results in increased oxidation of YTHDC1 protein CTD PMID:28086193 NCBI chr14:22,971,834...23,002,326
Ensembl chr14:22,971,836...23,002,011 		JBrowse link
G Zfp148 zinc finger protein 148 increases oxidation EXP linsidomine results in increased oxidation of ZFP148 protein CTD PMID:28086193 NCBI chr11:70,509,909...70,618,422
Ensembl chr11:70,514,750...70,618,347 		JBrowse link
G Zfp518a zinc finger protein 518A increases oxidation EXP linsidomine results in increased oxidation of ZFP518A protein CTD PMID:28086193 NCBI chr 1:260,152,881...260,178,360
Ensembl chr 1:260,153,645...260,178,349 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    chemical entity 19761
      atom 19759
        nonmetal atom 19641
          nitrogen atom 18572
            nitrogen molecular entity 18572
              organonitrogen compound 18361
                organonitrogen heterocyclic compound 17521
                  oxazinane 830
                    morpholines 830
                      linsidomine 131
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic molecule 19493
                              organic cyclic compound 19318
                                organic heterocyclic compound 18510
                                  organic heteromonocyclic compound 16986
                                    oxazinane 830
                                      morpholines 830
                                        linsidomine 131
paths to the root