CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: dapoxetine
Accession: CHEBI:135962
browse the term
Synonyms: related_synonym: Formula=C21H23NO; InChI=1S/C21H23NO/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21/h3-14,20H,15-16H2,1-2H3/t20-/m0/s1; InChIKey=USRHYDPUVLEVMC-FQEVSTJZSA-N; LY-210448; SMILES=O(CC[C@H](N(C)C)C1=CC=CC=C1)C=2C3=C(C=CC2)C=CC=C3; dapoxetine hydrochloride; priligy
xref: CAS:119356-77-3; Drug_Central:4381
xref_mesh: MESH:C080598
G
Ar
androgen receptor
multiple interactions
EXP
dapoxetine inhibits the reaction [Testosterone results in increased expression of AR mRNA]
CTD
PMID:27687055
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
G
Bax
BCL2 associated X, apoptosis regulator
multiple interactions
EXP
dapoxetine inhibits the reaction [Testosterone results in decreased expression of BAX protein]
CTD
PMID:27687055
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
G
Bcl2
BCL2, apoptosis regulator
multiple interactions
EXP
dapoxetine inhibits the reaction [Testosterone results in increased expression of BCL2 protein]
CTD
PMID:27687055
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
G
Casp3
caspase 3
multiple interactions
EXP
dapoxetine inhibits the reaction [Testosterone results in decreased expression of CASP3 protein modified form]
CTD
PMID:27687055
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
G
Nos2
nitric oxide synthase 2
multiple interactions
EXP
dapoxetine inhibits the reaction [Testosterone results in increased expression of NOS2 protein]
CTD
PMID:27687055
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
G
Pcna
proliferating cell nuclear antigen
multiple interactions
EXP
dapoxetine inhibits the reaction [Testosterone results in increased expression of PCNA mRNA]
CTD
PMID:27687055
NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP
dapoxetine inhibits the reaction [Testosterone results in increased expression of PTGS2 protein]
CTD
PMID:27687055
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
G
Tnf
tumor necrosis factor
multiple interactions
EXP
dapoxetine inhibits the reaction [Testosterone results in increased expression of TNF protein]
CTD
PMID:27687055
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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