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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tapentadol
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Accession:CHEBI:135935 term browser browse the term
Synonyms:related_synonym: Formula=C14H23NO;   InChI=1S/C14H23NO/c1-5-14(11(2)10-15(3)4)12-7-6-8-13(16)9-12/h6-9,11,14,16H,5,10H2,1-4H3/t11-,14+/m0/s1;   InChIKey=KWTWDQCKEHXFFR-SMDDNHRTSA-N;   SMILES=[C@H]([C@H](CN(C)C)C)(CC)C1=CC(O)=CC=C1;   nucynta;   tapentadol HCl;   tapentadol hydrochloride
 xref: CAS:175591-09-0;   Drug_Central:4283
 xref_mesh: MESH:C523979


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tapentadol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldoc aldolase C, fructose-bisphosphate increases expression ISO tapentadol results in increased expression of ALDOC mRNA CTD PMID:27317026 NCBI chr11:78,323,073...78,327,781
Ensembl chr11:78,322,968...78,327,781
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO tapentadol results in decreased activity of BCHE protein CTD PMID:28689766 NCBI chr 3:73,635,805...73,708,436
Ensembl chr 3:73,635,808...73,708,415
JBrowse link
G Casp3 caspase 3 increases activity ISO tapentadol results in increased activity of CASP3 protein CTD PMID:27317026 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp9 caspase 9 affects activity ISO tapentadol affects the activity of CASP9 protein CTD PMID:27317026 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Ckb creatine kinase, brain decreases expression ISO tapentadol results in decreased expression of CKB mRNA CTD PMID:27317026 NCBI chr12:111,669,355...111,672,338
Ensembl chr12:111,669,361...111,672,338
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble increases activity ISO tapentadol results in increased activity of GPT protein CTD PMID:28689766 NCBI chr15:76,696,726...76,699,675
Ensembl chr15:76,695,716...76,699,686
JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO tapentadol results in decreased expression of LDHA mRNA CTD PMID:27317026 NCBI chr 7:46,842,274...46,855,627
Ensembl chr 7:46,841,475...46,855,627
JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 decreases expression ISO tapentadol results in decreased expression of NDUFS1 mRNA CTD PMID:27317026 NCBI chr 1:63,143,592...63,176,822
Ensembl chr 1:63,143,596...63,176,833
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding ISO tapentadol binds to OPRD1 protein CTD PMID:17656655 NCBI chr 4:132,110,188...132,144,486
Ensembl chr 4:132,110,726...132,144,486
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding ISO tapentadol binds to OPRK1 protein CTD PMID:17656655 NCBI chr 1:5,588,450...5,606,134
Ensembl chr 1:5,588,466...5,606,131
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
ISO tapentadol binds to and results in increased activity of OPRM1 protein
tapentadol binds to OPRM1 protein
CTD PMID:17656655 NCBI chr10:6,758,593...7,038,209
Ensembl chr10:6,758,506...7,038,198
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase, isoenzyme 3 increases expression ISO tapentadol results in increased expression of PDK3 mRNA CTD PMID:27317026 NCBI chr  X:93,764,616...93,832,150
Ensembl chr  X:93,764,607...93,832,201
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21746
    role 21724
      chemical role 20849
        environmental contaminant 19357
          benzene 5717
            alkylbenzene 3383
              tapentadol 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 21746
    subatomic particle 21732
      composite particle 21732
        hadron 21732
          baryon 21732
            nucleon 21732
              atomic nucleus 21732
                atom 21732
                  main group element atom 21647
                    main group molecular entity 21647
                      s-block molecular entity 21180
                        hydrogen molecular entity 21117
                          hydrides 20363
                            organic hydride 19898
                              organic fundamental parent 19898
                                hydrocarbon 19745
                                  cyclic hydrocarbon 17894
                                    monocyclic hydrocarbon 5889
                                      annulene 5717
                                        aromatic annulene 5717
                                          benzene 5717
                                            alkylbenzene 3383
                                              tapentadol 12
paths to the root