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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tapentadol
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Accession:CHEBI:135935 term browser browse the term
Synonyms:related_synonym: Formula=C14H23NO;   InChI=1S/C14H23NO/c1-5-14(11(2)10-15(3)4)12-7-6-8-13(16)9-12/h6-9,11,14,16H,5,10H2,1-4H3/t11-,14+/m0/s1;   InChIKey=KWTWDQCKEHXFFR-SMDDNHRTSA-N;   SMILES=[C@H]([C@H](CN(C)C)C)(CC)C1=CC(O)=CC=C1;   nucynta;   tapentadol HCl;   tapentadol hydrochloride
 xref: CAS:175591-09-0;   Drug_Central:4283
 xref_mesh: MESH:C523979


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tapentadol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDOC aldolase, fructose-bisphosphate C increases expression EXP tapentadol results in increased expression of ALDOC mRNA CTD PMID:27317026 NCBI chr17:28,573,115...28,576,963
Ensembl chr17:28,573,115...28,576,948
JBrowse link
G BCHE butyrylcholinesterase decreases activity ISO tapentadol results in decreased activity of BCHE protein CTD PMID:28689766 NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462
JBrowse link
G CASP3 caspase 3 increases activity EXP tapentadol results in increased activity of CASP3 protein CTD PMID:27317026 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP9 caspase 9 affects activity EXP tapentadol affects the activity of CASP9 protein CTD PMID:27317026 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CKB creatine kinase B decreases expression EXP tapentadol results in decreased expression of CKB mRNA CTD PMID:27317026 NCBI chr14:103,519,667...103,522,833
Ensembl chr14:103,519,667...103,522,833
JBrowse link
G GPT glutamic--pyruvic transaminase increases activity ISO tapentadol results in increased activity of GPT protein CTD PMID:28689766 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G LDHA lactate dehydrogenase A decreases expression EXP tapentadol results in decreased expression of LDHA mRNA CTD PMID:27317026 NCBI chr11:18,394,563...18,408,425
Ensembl chr11:18,394,560...18,408,425
JBrowse link
G NDUFS1 NADH:ubiquinone oxidoreductase core subunit S1 decreases expression EXP tapentadol results in decreased expression of NDUFS1 mRNA CTD PMID:27317026 NCBI chr 2:206,114,817...206,159,444
Ensembl chr 2:206,114,817...206,159,509
JBrowse link
G OPRD1 opioid receptor delta 1 affects binding ISO tapentadol binds to OPRD1 protein CTD PMID:17656655 NCBI chr 1:28,812,170...28,871,267
Ensembl chr 1:28,812,142...28,871,267
JBrowse link
G OPRK1 opioid receptor kappa 1 affects binding ISO tapentadol binds to OPRK1 protein CTD PMID:17656655 NCBI chr 8:53,225,724...53,251,637
Ensembl chr 8:53,225,724...53,251,637
JBrowse link
G OPRM1 opioid receptor mu 1 multiple interactions
affects binding
EXP
ISO
tapentadol binds to and results in increased activity of OPRM1 protein
tapentadol binds to OPRM1 protein
CTD PMID:17656655 NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867
JBrowse link
G PDK3 pyruvate dehydrogenase kinase 3 increases expression EXP tapentadol results in increased expression of PDK3 mRNA CTD PMID:27317026 NCBI chr  X:24,465,286...24,550,466
Ensembl chr  X:24,465,270...24,550,466
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24779
    role 24695
      chemical role 22999
        environmental contaminant 20074
          benzene 6000
            alkylbenzene 3496
              tapentadol 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 24779
    subatomic particle 24738
      composite particle 24738
        hadron 24738
          baryon 24738
            nucleon 24738
              atomic nucleus 24738
                atom 24738
                  main group element atom 24603
                    main group molecular entity 24603
                      s-block molecular entity 23910
                        hydrogen molecular entity 23749
                          hydrides 21960
                            organic hydride 21448
                              organic fundamental parent 21448
                                hydrocarbon 21127
                                  cyclic hydrocarbon 19954
                                    monocyclic hydrocarbon 6171
                                      annulene 6000
                                        aromatic annulene 6000
                                          benzene 6000
                                            alkylbenzene 3496
                                              tapentadol 12
paths to the root