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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tapentadol
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Accession:CHEBI:135935 term browser browse the term
Synonyms:related_synonym: Formula=C14H23NO;   InChI=1S/C14H23NO/c1-5-14(11(2)10-15(3)4)12-7-6-8-13(16)9-12/h6-9,11,14,16H,5,10H2,1-4H3/t11-,14+/m0/s1;   InChIKey=KWTWDQCKEHXFFR-SMDDNHRTSA-N;   SMILES=[C@H]([C@H](CN(C)C)C)(CC)C1=CC(O)=CC=C1;   nucynta;   tapentadol HCl;   tapentadol hydrochloride
 xref: CAS:175591-09-0;   Drug_Central:4283
 xref_mesh: MESH:C523979


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tapentadol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldoc aldolase, fructose-bisphosphate C increases expression ISO tapentadol results in increased expression of ALDOC mRNA CTD PMID:27317026 NCBI chr10:65,586,504...65,590,093
Ensembl chr10:65,586,504...65,590,126
JBrowse link
G Bche butyrylcholinesterase decreases activity EXP tapentadol results in decreased activity of BCHE protein CTD PMID:28689766 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Casp3 caspase 3 increases activity ISO tapentadol results in increased activity of CASP3 protein CTD PMID:27317026 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 affects activity ISO tapentadol affects the activity of CASP9 protein CTD PMID:27317026 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ckb creatine kinase B decreases expression ISO tapentadol results in decreased expression of CKB mRNA CTD PMID:27317026 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP tapentadol results in increased activity of GPT protein CTD PMID:28689766 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO tapentadol results in decreased expression of LDHA mRNA CTD PMID:27317026 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 decreases expression ISO tapentadol results in decreased expression of NDUFS1 mRNA CTD PMID:27317026 NCBI chr 9:69,919,863...69,953,182
Ensembl chr 9:69,919,867...69,953,182
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP tapentadol binds to OPRD1 protein CTD PMID:17656655 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP tapentadol binds to OPRK1 protein CTD PMID:17656655 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
ISO
EXP
tapentadol binds to and results in increased activity of OPRM1 protein
tapentadol binds to OPRM1 protein
CTD PMID:17656655 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 increases expression ISO tapentadol results in increased expression of PDK3 mRNA CTD PMID:27317026 NCBI chr  X:62,836,131...62,904,114
Ensembl chr  X:62,836,131...62,903,554
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      chemical role 19256
        environmental contaminant 18595
          benzene 5643
            alkylbenzene 3365
              tapentadol 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    main group molecular entity 19658
                      s-block molecular entity 19423
                        hydrogen molecular entity 19416
                          hydrides 18755
                            organic hydride 18356
                              organic fundamental parent 18356
                                hydrocarbon 18074
                                  cyclic hydrocarbon 17089
                                    monocyclic hydrocarbon 5816
                                      annulene 5643
                                        aromatic annulene 5643
                                          benzene 5643
                                            alkylbenzene 3365
                                              tapentadol 12
paths to the root