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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:migalastat
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Accession:CHEBI:135923 term browser browse the term
Synonyms:related_synonym: 1-Deoxygalactonojirimycin;   1-Deoxygalactonojirimycin hydrochloride;   Formula=C6H13NO4;   GR181413A;   InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5+,6-/m1/s1;   InChIKey=LXBIFEVIBLOUGU-DPYQTVNSSA-N;   SMILES=[C@H]1([C@H]([C@H]([C@H](NC1)CO)O)O)O;   galafold;   migalastat HCl;   migalastat hydrochloride
 xref: CAS:108147-54-2;   Drug_Central:5110
 xref_mesh: MESH:C090092


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migalastat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gla galactosidase, alpha multiple interactions ISO [GLA protein mutant form binds to GLA protein mutant form] which results in decreased susceptibility to migalastat CTD PMID:22773828 NCBI chr  X:105,405,915...105,417,331
Ensembl chr  X:105,406,792...105,417,323
JBrowse link
G Lct lactase decreases activity
multiple interactions
EXP migalastat results in decreased activity of LCT protein
[migalastat results in decreased activity of LCT protein] which results in decreased hydrolysis of isoquercitrin; [migalastat results in decreased activity of LCT protein] which results in decreased hydrolysis of spiraeoside; [migalastat results in decreased activity of LCT protein] which results in decreased uptake of Quercetin
CTD PMID:12663055 NCBI chr13:44,998,414...45,040,593
Ensembl chr13:44,998,414...45,040,593
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19786
    chemical entity 19786
      atom 19784
        nonmetal atom 19666
          nitrogen atom 18655
            nitrogen molecular entity 18655
              organonitrogen compound 18407
                organonitrogen heterocyclic compound 17604
                  piperidines 7570
                    migalastat 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19596
                        carbon atom 19586
                          organic molecular entity 19586
                            organic molecule 19519
                              organic cyclic compound 19349
                                organic heterocyclic compound 18574
                                  organic heteromonocyclic compound 17072
                                    piperidines 7570
                                      migalastat 2
paths to the root