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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:migalastat
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Accession:CHEBI:135923 term browser browse the term
Synonyms:related_synonym: 1-Deoxygalactonojirimycin;   1-Deoxygalactonojirimycin hydrochloride;   Formula=C6H13NO4;   GR181413A;   InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5+,6-/m1/s1;   InChIKey=LXBIFEVIBLOUGU-DPYQTVNSSA-N;   SMILES=[C@H]1([C@H]([C@H]([C@H](NC1)CO)O)O)O;   galafold;   migalastat HCl;   migalastat hydrochloride
 xref: CAS:108147-54-2;   Drug_Central:5110
 xref_mesh: MESH:C090092


show annotations for term's descendants           Sort by:
 
migalastat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gla galactosidase, alpha multiple interactions ISO [GLA protein mutant form binds to GLA protein mutant form] which results in decreased susceptibility to migalastat CTD PMID:22773828 NCBI chr  X:105,405,915...105,417,331
Ensembl chr  X:105,406,792...105,417,323
JBrowse link
G Lct lactase decreases activity
multiple interactions
EXP migalastat results in decreased activity of LCT protein
[migalastat results in decreased activity of LCT protein] which results in decreased hydrolysis of isoquercitrin; [migalastat results in decreased activity of LCT protein] which results in decreased hydrolysis of spiraeoside; [migalastat results in decreased activity of LCT protein] which results in decreased uptake of Quercetin
CTD PMID:12663055 NCBI chr13:44,998,414...45,040,593
Ensembl chr13:44,998,414...45,040,593
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    chemical entity 19773
      atom 19772
        nonmetal atom 19651
          nitrogen atom 18622
            nitrogen molecular entity 18622
              organonitrogen compound 18366
                organonitrogen heterocyclic compound 17522
                  piperidines 7570
                    migalastat 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19579
                        carbon atom 19569
                          organic molecular entity 19569
                            organic molecule 19502
                              organic cyclic compound 19329
                                organic heterocyclic compound 18544
                                  organic heteromonocyclic compound 16992
                                    piperidines 7570
                                      migalastat 2
paths to the root