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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pimecrolimus
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Accession:CHEBI:135888 term browser browse the term
Synonyms:related_synonym: Formula=C43H68ClNO11;   InChI=1S/C43H68ClNO11/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)45-16-12-11-13-32(45)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-31(44)35(22-29)52-7/h18,20,25,27-33,35-39,46,51H,10-17,19,21-23H2,1-9H3/b24-18+,26-20+/t25-,27+,28+,29-,30+,31-,32-,33-,35+,36-,37-,38+,39+,43+/m0/s1;   InChIKey=KASDHRXLYQOAKZ-XDSKOBMDSA-N;   SMILES=O(C)[C@@H]1[C@@]2(O[C@@]([C@@H](C1)C)(O)C(=O)C(=O)N3[C@](C(=O)O[C@H](/C(=C/[C@H]4C[C@@H](OC)[C@H](CC4)Cl)/C)[C@@H]([C@H](CC([C@@H](C=C(C[C@@H](C[C@@H]2OC)C)C)CC)=O)O)C)(CCCC3)[H])[H];   elidel;   picrolimus
 xref: CAS:137071-32-0;   Drug_Central:2168
 xref_mesh: MESH:C117268


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pimecrolimus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO pimecrolimus results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO pimecrolimus inhibits the reaction [Rifampin results in increased expression of ABCB1 mRNA] CTD PMID:29356861 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions ISO pimecrolimus inhibits the reaction [Rifampin results in increased expression of AKR1B10 mRNA] CTD PMID:29356861 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Csf2 colony stimulating factor 2 increases secretion ISO pimecrolimus results in increased secretion of CSF2 protein CTD PMID:15086553 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO pimecrolimus results in increased expression of CYP2B6 mRNA CTD PMID:29356861 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO pimecrolimus inhibits the reaction [Rifampin results in increased expression of CYP2C8 mRNA] CTD PMID:29356861 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases expression ISO pimecrolimus results in increased expression of CYP3A4 mRNA CTD PMID:29356861 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Ephx1 epoxide hydrolase 1 multiple interactions ISO pimecrolimus inhibits the reaction [Rifampin results in increased expression of EPHX1 mRNA] CTD PMID:29356861 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO pimecrolimus inhibits the reaction [Rifampin results in increased expression of FASN mRNA] CTD PMID:29356861 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO pimecrolimus results in decreased expression of ICAM1 protein CTD PMID:12296857 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma decreases expression ISO pimecrolimus results in decreased expression of IFNG protein CTD PMID:12296857 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1a interleukin 1 alpha increases secretion ISO pimecrolimus results in increased secretion of IL1A protein CTD PMID:15086553 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases expression ISO pimecrolimus results in decreased expression of IL2RA protein CTD PMID:12296857 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO pimecrolimus inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; pimecrolimus promotes the reaction [NCOA1 protein binds to NR1I2 protein] CTD PMID:29356861 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
affects binding
ISO pimecrolimus inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; pimecrolimus inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; pimecrolimus inhibits the reaction [TO-901317 results in increased activity of NR1I2 protein]; pimecrolimus promotes the reaction [NCOA1 protein binds to NR1I2 protein]
pimecrolimus binds to NR1I2 protein
CTD PMID:29356861 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Tnf tumor necrosis factor decreases expression
increases secretion
ISO pimecrolimus results in decreased expression of TNF protein
pimecrolimus results in increased secretion of TNF protein
CTD PMID:12296857 PMID:15086553 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf4 TNF receptor superfamily member 4 decreases expression ISO pimecrolimus results in decreased expression of TNFRSF4 protein CTD PMID:12296857 NCBI chr 5:173,447,784...173,450,474
Ensembl chr 5:173,447,784...173,450,474
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO pimecrolimus inhibits the reaction [Rifampin results in increased expression of UGT1A3 mRNA] CTD PMID:29356861 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19841
      atom 19839
        nonmetal atom 19720
          nitrogen atom 18613
            nitrogen molecular entity 18613
              amide 17452
                cyclic amide 8034
                  lactam 8034
                    pimecrolimus 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18113
                                        carboacyl group 17377
                                          univalent carboacyl group 17377
                                            carbamoyl group 17164
                                              carboxamide 17164
                                                lactam 8034
                                                  pimecrolimus 18
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