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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benidipine
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Accession:CHEBI:135806 term browser browse the term
Synonyms:related_synonym: Formula=C28H31N3O6;   InChI=1S/C28H31N3O6/c1-18-24(27(32)36-3)26(21-11-7-12-22(15-21)31(34)35)25(19(2)29-18)28(33)37-23-13-8-14-30(17-23)16-20-9-5-4-6-10-20/h4-7,9-12,15,23,26,29H,8,13-14,16-17H2,1-3H3/t23-,26?/m1/s1;   InChIKey=QZVNQOLPLYWLHQ-GEPVFLLWSA-N;   SMILES=C(O[C@H]1CN(CC2=CC=CC=C2)CCC1)(=O)C=3C(C(C(OC)=O)=C(NC3C)C)C4=CC([N+](=O)[O-])=CC=C4;   benidipine HCl;   benidipine hydrochloride;   coniel
 xref: CAS:105979-17-7;   Drug_Central:3880
 xref_mesh: MESH:C061004


show annotations for term's descendants           Sort by:
benidipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO benidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:11895100 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Agt angiotensinogen multiple interactions ISO [Valsartan co-treated with benidipine] inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; benidipine inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; benidipine inhibits the reaction [AGT protein results in increased expression of CYP11B1 mRNA]; benidipine inhibits the reaction [AGT protein results in increased uptake of Calcium] CTD PMID:18331727 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Ahr aryl hydrocarbon receptor increases activity ISO benidipine results in increased activity of AHR protein CTD PMID:27732883 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ar androgen receptor decreases activity ISO benidipine results in decreased activity of AR protein CTD PMID:25257666 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain affects expression ISO benidipine affects the expression of COL4A1 mRNA CTD PMID:15721868 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 multiple interactions ISO benidipine inhibits the reaction [AGT protein results in increased expression of CYP11B1 mRNA]; benidipine inhibits the reaction [Potassium Chloride results in increased expression of CYP11B1 mRNA] CTD PMID:18331727 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 multiple interactions ISO benidipine inhibits the reaction [Potassium Chloride results in increased expression of CYP11B2 mRNA] CTD PMID:18331727 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases expression		 ISO benidipine results in decreased activity of CYP1A1 protein
benidipine results in increased expression of CYP1A1 mRNA		 CTD PMID:10805063 PMID:27732883 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO benidipine results in increased expression of CYP1A2 mRNA CTD PMID:27732883 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO benidipine results in increased expression of CYP2B6 mRNA; benidipine results in increased expression of CYP2B6 protein CTD PMID:27732883 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity ISO benidipine results in decreased activity of CYP2C9 protein CTD PMID:10805063 PMID:27732883 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO benidipine results in decreased activity of CYP2C19 protein CTD PMID:10805063 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO benidipine results in decreased activity of CYP2D6 protein CTD PMID:10805063 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO benidipine results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
increases expression
multiple interactions		 ISO benidipine results in decreased activity of CYP3A4 protein
benidipine results in increased expression of CYP3A4 mRNA
benidipine results in increased expression of and results in decreased activity of CYP3A4 protein		 CTD PMID:10805063 PMID:27732883 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Dynll1 dynein light chain LC8-type 1 affects expression ISO benidipine affects the expression of DYNLL1 mRNA CTD PMID:15721868 NCBI chr12:41,312,367...41,314,742
Ensembl chr12:41,312,367...41,314,741 		JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO benidipine results in decreased activity of ESR1 protein CTD PMID:25257666 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO benidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Nppb natriuretic peptide B affects expression ISO benidipine affects the expression of NPPB mRNA CTD PMID:15721868 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity
decreases activity
multiple interactions		 ISO benidipine results in increased activity of NR1H4 protein
benidipine results in decreased activity of NR1H4 protein
benidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; benidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]		 CTD PMID:25257666 PMID:27773686 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO benidipine results in increased activity of NR1I2 protein CTD PMID:27732883 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    chemical entity 19816
      atom 19816
        nonmetal atom 19749
          nitrogen atom 18922
            nitrogen molecular entity 18922
              organonitrogen compound 18757
                organonitrogen heterocyclic compound 18027
                  piperidines 7711
                    benidipine 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic molecule 19656
                              organic cyclic compound 19461
                                organic heterocyclic compound 18817
                                  organic heteromonocyclic compound 17582
                                    piperidines 7711
                                      benidipine 21
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