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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benidipine
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Accession:CHEBI:135806 term browser browse the term
Synonyms:related_synonym: Formula=C28H31N3O6;   InChI=1S/C28H31N3O6/c1-18-24(27(32)36-3)26(21-11-7-12-22(15-21)31(34)35)25(19(2)29-18)28(33)37-23-13-8-14-30(17-23)16-20-9-5-4-6-10-20/h4-7,9-12,15,23,26,29H,8,13-14,16-17H2,1-3H3/t23-,26?/m1/s1;   InChIKey=QZVNQOLPLYWLHQ-GEPVFLLWSA-N;   SMILES=C(O[C@H]1CN(CC2=CC=CC=C2)CCC1)(=O)C=3C(C(C(OC)=O)=C(NC3C)C)C4=CC([N+](=O)[O-])=CC=C4;   benidipine HCl;   benidipine hydrochloride;   coniel
 xref: CAS:105979-17-7;   Drug_Central:3880
 xref_mesh: MESH:C061004


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benidipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO benidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:11895100 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Agt angiotensinogen multiple interactions ISO [Valsartan co-treated with benidipine] inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; benidipine inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; benidipine inhibits the reaction [AGT protein results in increased expression of CYP11B1 mRNA]; benidipine inhibits the reaction [AGT protein results in increased uptake of Calcium] CTD PMID:18331727 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Ahr aryl hydrocarbon receptor increases activity ISO benidipine results in increased activity of AHR protein CTD PMID:27732883 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ar androgen receptor decreases activity ISO benidipine results in decreased activity of AR protein CTD PMID:25257666 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Col4a1 collagen type IV alpha 1 chain affects expression ISO benidipine affects the expression of COL4A1 mRNA CTD PMID:15721868 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 multiple interactions ISO benidipine inhibits the reaction [AGT protein results in increased expression of CYP11B1 mRNA]; benidipine inhibits the reaction [Potassium Chloride results in increased expression of CYP11B1 mRNA] CTD PMID:18331727 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 multiple interactions ISO benidipine inhibits the reaction [Potassium Chloride results in increased expression of CYP11B2 mRNA] CTD PMID:18331727 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases expression
ISO benidipine results in decreased activity of CYP1A1 protein
benidipine results in increased expression of CYP1A1 mRNA
CTD PMID:10805063 PMID:27732883 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO benidipine results in increased expression of CYP1A2 mRNA CTD PMID:27732883 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO benidipine results in increased expression of CYP2B6 mRNA; benidipine results in increased expression of CYP2B6 protein CTD PMID:27732883 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO benidipine results in decreased activity of CYP2C19 protein CTD PMID:10805063 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO benidipine results in decreased activity of CYP2D6 protein CTD PMID:10805063 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO benidipine results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity
multiple interactions
increases expression
ISO benidipine results in decreased activity of CYP3A4 protein
benidipine results in increased expression of and results in decreased activity of CYP3A4 protein
benidipine results in increased expression of CYP3A4 mRNA
CTD PMID:10805063 PMID:27732883 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Dynll1 dynein light chain LC8-type 1 affects expression ISO benidipine affects the expression of DYNLL1 mRNA CTD PMID:15721868 NCBI chr12:47,074,200...47,076,573
Ensembl chr12:47,074,200...47,076,572
JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO benidipine results in decreased activity of ESR1 protein CTD PMID:25257666 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO benidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nppb natriuretic peptide B affects expression ISO benidipine affects the expression of NPPB mRNA CTD PMID:15721868 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity
decreases activity
multiple interactions
ISO benidipine results in increased activity of NR1H4 protein
benidipine results in decreased activity of NR1H4 protein
benidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; benidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
CTD PMID:25257666 PMID:27773686 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO benidipine results in increased activity of NR1I2 protein CTD PMID:27732883 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    chemical entity 19883
      atom 19881
        nonmetal atom 19760
          nitrogen atom 18646
            nitrogen molecular entity 18646
              organonitrogen compound 18422
                organonitrogen heterocyclic compound 17582
                  piperidines 7569
                    benidipine 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic molecule 19596
                              organic cyclic compound 19407
                                organic heterocyclic compound 18517
                                  organic heteromonocyclic compound 16622
                                    piperidines 7569
                                      benidipine 20
paths to the root