Term: | amrubicin |
|
Accession: | CHEBI:135779
|
browse the term
|
Definition: | A synthetic anthracycline antibiotic with molecular formula C25H25NO9. A specific inhibitor of topoisomerase II, it is used (particularly as the hydrochloride salt) in the treatment of cancer, especially lung cancer, where it is a prodrug for the active metabolite, ambrucinol. |
Synonyms: | exact_synonym: | (1S,3S)-3-acetyl-3-amino-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 2-deoxy-beta-D-erythro-pentopyranoside |
| related_synonym: | (7S,9S)-9-acetyl-9-amino-7-{[(2S,4S,5R)-4,5-dihydroxytetrahydro-2H-pyran-2-yl]oxy}-6,11-dihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione; Formula=C25H25NO9; InChI=1S/C25H25NO9/c1-10(27)25(26)7-13-18(16(8-25)35-17-6-14(28)15(29)9-34-17)24(33)20-19(23(13)32)21(30)11-4-2-3-5-12(11)22(20)31/h2-5,14-17,28-29,32-33H,6-9,26H2,1H3/t14-,15+,16-,17-,25-/m0/s1; InChIKey=VJZITPJGSQKZMX-XDPRQOKASA-N; SM-5887; SMILES=O([C@H]1C[C@H](O)[C@@H](CO1)O)[C@@H]2C=3C(=C(O)C4=C(C3O)C(=O)C=5C(C4=O)=CC=CC5)C[C@](C2)(C(C)=O)N; amrubicina; amrubicine; amrubicinum |
| xref: | CAS:110267-81-7; Drug_Central:202; KEGG:D08854; PMID:31505087; PMID:31557562; PMID:31901017; PMID:32462731; PMID:32569168; PMID:32582522; PMID:32606979; PMID:9849587; Wikipedia:Amrubicin |
|
|