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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ormeloxifene
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Accession:CHEBI:135742 term browser browse the term
Synonyms:related_synonym: Formula=C30H35NO3;   InChI=1S/C30H35NO3/c1-30(2)29(23-9-5-4-6-10-23)28(26-16-15-25(32-3)21-27(26)34-30)22-11-13-24(14-12-22)33-20-19-31-17-7-8-18-31/h4-6,9-16,21,28-29H,7-8,17-20H2,1-3H3;   InChIKey=XZEUAXYWNKYKPL-UHFFFAOYSA-N;   SMILES=C1(C(C(C=2C(O1)=CC(=CC2)OC)C3=CC=C(C=C3)OCCN4CCCC4)C5=CC=CC=C5)(C)C;   centchroman;   centron;   ormeloxifen
 xref: CAS:31477-60-8;   Drug_Central:570
 xref_mesh: MESH:D002486



show annotations for term's descendants           Sort by:
ormeloxifene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bglap bone gamma-carboxyglutamate protein affects expression EXP ormeloxifene affects the expression of BGLAP protein CTD PMID:15261309 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions EXP [Estradiol co-treated with ormeloxifene] promotes the reaction [NCOR1 protein binds to ESR1 protein]; [Estradiol co-treated with ormeloxifene] promotes the reaction [NRIP1 protein binds to ESR1 protein]; [Estradiol co-treated with ormeloxifene] results in decreased expression of ESR1 protein; ormeloxifene inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]]; ormeloxifene promotes the reaction [NCOR1 protein binds to ESR1 protein] CTD PMID:19460436 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions EXP ormeloxifene inhibits the reaction [ESR2 protein binds to NCOA1 protein] CTD PMID:19460436 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions EXP ormeloxifene inhibits the reaction [ESR2 protein binds to NCOA1 protein]; ormeloxifene inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]] CTD PMID:19460436 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions EXP [Estradiol co-treated with ormeloxifene] promotes the reaction [NCOR1 protein binds to ESR1 protein]; ormeloxifene promotes the reaction [NCOR1 protein binds to ESR1 protein] CTD PMID:19460436 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 multiple interactions EXP [Estradiol co-treated with ormeloxifene] promotes the reaction [NRIP1 protein binds to ESR1 protein] CTD PMID:19460436 NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
JBrowse link
G Pgr progesterone receptor multiple interactions
increases expression
EXP [Centchroman co-treated with Estradiol] results in decreased expression of PGR protein; ormeloxifene inhibits the reaction [Estradiol results in increased expression of PGR mRNA]
Centchroman results in increased expression of PGR protein; ormeloxifene results in increased expression of PGR mRNA
CTD PMID:15914137 PMID:19460436 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Tgfb3 transforming growth factor, beta 3 affects expression EXP ormeloxifene affects the expression of TGFB3 mRNA CTD PMID:16797179 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    chemical entity 19916
      atom 19916
        nonmetal atom 19852
          carbon atom 19806
            organic molecular entity 19806
              flavonoids 11429
                ormeloxifene 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            heteroorganic entity 19548
                              organochalcogen compound 19303
                                organooxygen compound 19217
                                  ether 17308
                                    ormeloxifene 8
paths to the root