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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sarpogrelate
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Accession:CHEBI:135697 term browser browse the term
Synonyms:related_synonym: Formula=C24H31NO6;   InChI=1S/C24H31NO6/c1-25(2)16-21(31-24(28)14-13-23(26)27)17-30-22-10-5-4-8-19(22)12-11-18-7-6-9-20(15-18)29-3/h4-10,15,21H,11-14,16-17H2,1-3H3,(H,26,27);   InChIKey=FFYNAVGJSYHHFO-UHFFFAOYSA-N;   MCI-9042;   SMILES=C(C(=O)O)CC(OC(COC=1C=CC=CC1CCC=2C=CC=C(C2)OC)([H])CN(C)C)=O;   anplag;   sarpogrelate HCl;   sarpogrelate hydrochloride
 xref: CAS:125926-17-2;   Drug_Central:2423
 xref_mesh: MESH:C064294


show annotations for term's descendants           Sort by:
sarpogrelate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 multiple interactions ISO sarpogrelate inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; sarpogrelate metabolite inhibits the reaction [Serotonin results in increased expression of ACAT1 protein] CTD PMID:16157345 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO sarpogrelate results in increased expression of ADIPOQ protein CTD PMID:18235151 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions ISO sarpogrelate inhibits the reaction [Prazosin binds to ADRA1A protein] CTD PMID:11937776 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Adra1b adrenoceptor alpha 1B multiple interactions ISO sarpogrelate inhibits the reaction [Prazosin binds to ADRA1B protein] CTD PMID:11937776 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919 		JBrowse link
G Adra1d adrenoceptor alpha 1D multiple interactions ISO sarpogrelate inhibits the reaction [Prazosin binds to ADRA1D protein] CTD PMID:11937776 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein] CTD PMID:22975078 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 affects expression EXP sarpogrelate affects the expression of ATP2A2 mRNA; sarpogrelate affects the expression of ATP2A2 protein CTD PMID:18088389 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of BAX protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]
Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]		 CTD PMID:34560070 PMID:35202708 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]; sarpogrelate inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]; sarpogrelate inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]		 CTD PMID:34560070 PMID:35202708 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]		 CTD PMID:34560070 PMID:35202708 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]		 CTD PMID:34560070 PMID:35202708 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression		 ISO sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CCL2 protein]
sarpogrelate results in decreased expression of CCL2 protein		 CTD PMID:18235151 PMID:26824242 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity
multiple interactions		 ISO sarpogrelate metabolite results in decreased activity of CYP2D6 protein; sarpogrelate results in decreased activity of CYP2D6 protein
sarpogrelate inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]; sarpogrelate metabolite inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]		 CTD PMID:24167220 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Ddc dopa decarboxylase multiple interactions ISO sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of DDC protein]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of DDC protein]		 CTD PMID:34560070 PMID:35202708 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]
Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]		 CTD PMID:35202708 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Fabp1 fatty acid binding protein 1 multiple interactions ISO sarpogrelate inhibits the reaction [Oxygen deficiency results in increased expression of FABP1 protein] CTD PMID:24107419 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions ISO Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]
Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]		 CTD PMID:35202708 NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]] CTD PMID:35202708 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B multiple interactions EXP sarpogrelate inhibits the reaction [Iodocyanopindolol binds to HTR1B protein]; sarpogrelate metabolite inhibits the reaction [Iodocyanopindolol binds to HTR1B protein] CTD PMID:8937629 NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
affects binding		 ISO
EXP		 sarpogrelate binds to and results in decreased activity of HTR2A protein; sarpogrelate binds to and results in decreased activity of HTR2A protein mutant form; sarpogrelate metabolite binds to and results in decreased activity of HTR2A protein
sarpogrelate binds to HTR2A protein
sarpogrelate binds to HTR2A protein; sarpogrelate metabolite binds to HTR2A protein		 CTD PMID:8937629 PMID:16974069 PMID:17031071 PMID:19672037 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding ISO sarpogrelate binds to HTR2C protein CTD PMID:16880620 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO sarpogrelate inhibits the reaction [Glucose results in increased expression of ICAM1 protein] CTD PMID:23111892 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il18 interleukin 18 decreases expression ISO sarpogrelate results in decreased expression of IL18 protein CTD PMID:15080020 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased secretion of IL1B protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased secretion of IL1B protein]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of IL1B protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of IL1B protein]		 CTD PMID:34560070 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO sarpogrelate inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein] CTD PMID:11076827 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO [sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein] CTD PMID:22975078 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein] CTD PMID:27097221 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA mRNA]; [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of MAOA protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of MAOA protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]] CTD PMID:34560070 PMID:35202708 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Mfn1 mitofusin 1 multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]
Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]]		 CTD PMID:35202708 NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions EXP sarpogrelate inhibits the reaction [Oxygen deficiency results in increased expression of MMP13 mRNA] CTD PMID:25931318 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 multiple interactions ISO Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]
Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]		 CTD PMID:35202708 NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599 		JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b multiple interactions ISO Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]
Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]		 CTD PMID:35202708 NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278 		JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]
Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]]		 CTD PMID:35202708 NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO sarpogrelate inhibits the reaction [Palmitic Acid results in increased activity of MTOR protein]; sarpogrelate inhibits the reaction [Serotonin results in increased activity of MTOR protein] CTD PMID:27133527 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP sarpogrelate promotes the reaction [Oxygen deficiency results in increased expression of NOS3 protein] CTD PMID:25931318 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PECAM1 protein] CTD PMID:27097221 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Pln phospholamban affects expression EXP sarpogrelate affects the expression of PLN mRNA; sarpogrelate affects the expression of PLN protein CTD PMID:18088389 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 protein] CTD PMID:21262218 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein] CTD PMID:34560070 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Serpine2 serpin family E member 2 decreases expression
multiple interactions		 ISO sarpogrelate results in decreased expression of SERPINE2 mRNA
sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]		 CTD PMID:24107419 PMID:27097221 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 affects expression EXP sarpogrelate affects the expression of SLC2A1 protein CTD PMID:21183729 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 affects expression EXP sarpogrelate affects the expression of SLC2A4 protein CTD PMID:21183729 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Sorl1 sortilin related receptor 1 multiple interactions ISO sarpogrelate inhibits the reaction [Serotonin results in increased expression of SORL1 mRNA] CTD PMID:24650663 NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein] CTD PMID:34560070 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein] CTD PMID:24107419 PMID:27097221 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased secretion of TNF protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased secretion of TNF protein]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of TNF protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of TNF protein]		 CTD PMID:34560070 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tph1 tryptophan hydroxylase 1 multiple interactions ISO sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of TPH1 protein]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 mRNA]; [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 protein]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of TPH1 protein]		 CTD PMID:34560070 PMID:35202708 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of sarpogrelate metabolite CTD PMID:23704698 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of sarpogrelate metabolite CTD PMID:23704698 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO sarpogrelate inhibits the reaction [[Glucose co-treated with Serotonin] results in increased expression of VCAM1 protein] CTD PMID:22785018 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    chemical entity 19829
      atom 19829
        nonmetal atom 19767
          carbon atom 19724
            organic molecular entity 19724
              olefinic compound 16979
                stilbenoid 8329
                  sarpogrelate 50
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organochalcogen compound 19240
                                organooxygen compound 19155
                                  carbonyl compound 18874
                                    dicarboxylic acids and O-substituted derivatives 11047
                                      dicarboxylic acid 11041
                                        alpha,omega-dicarboxylic acid 3139
                                          succinic acid 654
                                            succinate ester 125
                                              hemisuccinate 121
                                                sarpogrelate 50
paths to the root