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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alvimopan
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Accession:CHEBI:135686 term browser browse the term
Synonyms:related_synonym: Formula=C25H32N2O4;   InChI=1S/C25H32N2O4/c1-18-16-27(12-11-25(18,2)21-9-6-10-22(28)14-21)17-20(24(31)26-15-23(29)30)13-19-7-4-3-5-8-19/h3-10,14,18,20,28H,11-13,15-17H2,1-2H3,(H,26,31)(H,29,30)/t18-,20-,25+/m0/s1;   InChIKey=UPNUIXSCZBYVBB-JVFUWBCBSA-N;   LY-246736;   LY246736;   SMILES=C[C@@]1([C@@H](C)CN(CC1)C[C@H](CC2=CC=CC=C2)C(NCC(O)=O)=O)C3=CC(O)=CC=C3;   alvimopan anhydrous;   alvimopan dihydrate;   entereg
 xref: CAS:156053-89-3;   Drug_Central:143;   HMDB:HMDB0015631
 xref_mesh: MESH:C419502


show annotations for term's descendants           Sort by:
alvimopan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprm1 opioid receptor, mu 1 affects binding
multiple interactions 		ISO alvimopan binds to OPRM1 protein; alvimopan metabolite binds to OPRM1 protein
alvimopan binds to and results in decreased activity of OPRM1 protein 		CTD PMID:17340127 PMID:18313920 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      group 20803
        organic group 19538
          amino-acid residue 11666
            peptide 11666
              alvimopan 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbon oxoacid 19155
                                    carboxylic acid 19152
                                      carboacyl group 18085
                                        univalent carboacyl group 18085
                                          carbamoyl group 17921
                                            carboxamide 17921
                                              peptide 11666
                                                alvimopan 1
paths to the root