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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:flunarizine
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Accession:CHEBI:135652 term browser browse the term
Synonyms:related_synonym: Formula=C26H26F2N2;   InChI=1S/C26H26F2N2/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21/h1-15,26H,16-20H2/b7-4+;   InChIKey=SMANXXCATUTDDT-QPJJXVBHSA-N;   SMILES=C(N1CCN(CC1)C/C=C/C2=CC=CC=C2)(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F;   flunarizine HCl;   flunarizine dihydrochloride;   flunarizine hydrochloride;   sibelium
 xref: CAS:52468-60-7;   Drug_Central:1200;   HMDB:HMDB0015589
 xref_mesh: MESH:D005444


show annotations for term's descendants           Sort by:
flunarizine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO Flunarizine inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein] CTD PMID:9533112 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Drd1 dopamine receptor D1 affects binding
multiple interactions		 ISO Flunarizine binds to DRD1; Flunarizine binds to DRD1 protein
Flunarizine inhibits the reaction [SCH 23390 binds to DRD1 protein]		 CTD PMID:8794996 PMID:9533112 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 affects binding
multiple interactions		 ISO
EXP		 Flunarizine binds to DRD2
Flunarizine binds to DRD2 protein
Flunarizine inhibits the reaction [Raclopride binds to DRD2 protein]
Flunarizine inhibits the reaction [nemonapride binds to DRD2 protein]		 CTD PMID:7503767 PMID:8794996 PMID:9533112 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Flunarizine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hexa hexosaminidase subunit alpha multiple interactions EXP Flunarizine inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of [HEXB protein binds to HEXA protein]] CTD PMID:19546254 NCBI chr 8:59,936,526...59,961,654
Ensembl chr 8:59,936,660...59,962,013 		JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP Flunarizine inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of [HEXB protein binds to HEXA protein]] CTD PMID:19546254 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP Flunarizine inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of INS1 protein] CTD PMID:19546254 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 multiple interactions EXP Flunarizine inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of LAMP1 protein] CTD PMID:19546254 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    chemical entity 19829
      group 19788
        polyatomic entity 19787
          molecule 19692
            cyclic compound 19508
              organic cyclic compound 19490
                organic aromatic compound 19359
                  diarylmethane 9439
                    flunarizine 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      p-block molecular entity 19779
                        carbon group molecular entity 19728
                          organic molecular entity 19724
                            organic molecule 19677
                              organic cyclic compound 19490
                                organic aromatic compound 19359
                                  diarylmethane 9439
                                    flunarizine 8
paths to the root