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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:camostat
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Accession:CHEBI:135632 term browser browse the term
Synonyms:related_synonym: Formula=C20H22N4O5;   InChI=1S/C20H22N4O5/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22/h3-10H,11-12H2,1-2H3,(H4,21,22,23);   InChIKey=XASIMHXSUQUHLV-UHFFFAOYSA-N;   SMILES=C(OC1=CC=C(C=C1)CC(OCC(N(C)C)=O)=O)(=O)C2=CC=C(C=C2)NC(=N)N;   camostat mesilate;   camostat mesylate
 xref: CAS:59721-28-7;   Drug_Central:471
 xref_mesh: MESH:C034532


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camostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cckar cholecystokinin A receptor increases expression EXP camostat results in increased expression of CCKAR mRNA CTD PMID:10458643 NCBI chr14:59,610,939...59,619,786
Ensembl chr14:59,611,434...59,619,783
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP camostat inhibits the reaction [PLG protein modified form results in increased expression of CCL2 mRNA] CTD PMID:27773435 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of CCN2 mRNA]; camostat inhibits the reaction [PLG protein modified form results in increased expression of CCN2 mRNA] CTD PMID:25766432, PMID:27773435 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
ISO PD 0325901 inhibits the reaction [camostat results in increased expression of CCND1 protein] CTD PMID:25104499 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd3 cyclin D3 multiple interactions
increases expression
ISO PD 0325901 inhibits the reaction [camostat results in increased expression of CCND3 protein] CTD PMID:25104499 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 increases expression
multiple interactions
ISO camostat results in increased expression of CCNE1 protein
PD 0325901 inhibits the reaction [camostat results in increased expression of CCNE1 protein]
CTD PMID:25104499 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of COL1A1 mRNA] CTD PMID:25766432 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of COL3A1 mRNA] CTD PMID:25766432 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of NOX2 mRNA] CTD PMID:25766432 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
ISO PD 0325901 inhibits the reaction [camostat results in increased expression of EGR1 mRNA] CTD PMID:25104499 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Fgf21 fibroblast growth factor 21 multiple interactions ISO camostat results in increased expression of and results in increased secretion of FGF21 protein CTD PMID:30920846 NCBI chr 1:101,595,579...101,596,822
Ensembl chr 1:101,595,579...101,596,822
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO PD 0325901 inhibits the reaction [camostat results in increased expression of FOS mRNA] CTD PMID:25104499 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Ier3 immediate early response 3 increases expression ISO camostat results in increased expression of IER3 mRNA CTD PMID:25104499 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
increases phosphorylation
ISO camostat results in increased expression of JUN mRNA
camostat results in increased phosphorylation of JUN protein
CTD PMID:25104499 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO camostat results in increased expression of JUNB mRNA CTD PMID:25104499 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO PD 0325901 inhibits the reaction [camostat results in increased phosphorylation of MAPK1 protein]; trametinib inhibits the reaction [camostat results in increased phosphorylation of MAPK1 protein] CTD PMID:25104499 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO camostat results in increased phosphorylation of MAPK3 protein
PD 0325901 inhibits the reaction [camostat results in increased phosphorylation of MAPK3 protein]; trametinib inhibits the reaction [camostat results in increased phosphorylation of MAPK3 protein]
CTD PMID:25104499 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression
multiple interactions
ISO camostat results in increased expression of MKI67 protein
PD 0325901 inhibits the reaction [camostat results in increased expression of MKI67 protein]
CTD PMID:25104499 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression EXP camostat results in increased expression of NOS3 mRNA CTD PMID:10458643 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of NOX1 mRNA] CTD PMID:25766432 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression
ISO PD 0325901 inhibits the reaction [camostat results in increased expression of PCNA protein] CTD PMID:25104499 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Plg plasminogen decreases activity
multiple interactions
EXP camostat results in decreased activity of PLG protein modified form
camostat inhibits the reaction [PLG protein modified form results in increased expression of CCL2 mRNA]; camostat inhibits the reaction [PLG protein modified form results in increased expression of CCN2 mRNA]; camostat inhibits the reaction [PLG protein modified form results in increased expression of TGFB1 mRNA]; camostat inhibits the reaction [PLG protein modified form results in increased expression of TNF mRNA]
CTD PMID:27773435 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
JBrowse link
G Rps6 ribosomal protein S6 increases phosphorylation ISO camostat results in increased phosphorylation of RPS6 protein CTD PMID:25104499 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of SERPINE1 mRNA] CTD PMID:25766432 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO camostat inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD2 protein] CTD PMID:26599507 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation ISO camostat results in increased phosphorylation of STAT3 protein CTD PMID:25104499 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP
camostat inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]
camostat inhibits the reaction [Adenine results in increased expression of TGFB1 mRNA]; camostat inhibits the reaction [PLG protein modified form results in increased expression of TGFB1 mRNA]
CTD PMID:25766432, PMID:26599507, PMID:27773435 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tmprss2 transmembrane serine protease 2 decreases activity ISO camostat results in decreased activity of TMPRSS2 protein CTD PMID:24027332 NCBI chr11:38,063,914...38,103,406
Ensembl chr11:38,063,915...38,103,290
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
camostat inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
camostat inhibits the reaction [PLG protein modified form results in increased expression of TNF mRNA]
CTD PMID:20023007, PMID:27773435 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        antimicrobial agent 17334
          antiviral agent 10253
            anticoronaviral agent 8944
              camostat 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      camostat 29
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.