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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:camostat
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Accession:CHEBI:135632 term browser browse the term
Definition:A benzoate ester resulting from the formal condensation of the carboxy group of 4-guanidinobenzoic acid with the hydroxy group of 2-(dimethylamino)-2-oxoethyl (4-hydroxyphenyl)acetate. It is a potent inhibitor of the human transmembrane protease serine 2 (TMPRSS2) and its mesylate salt is currently under investigation for its effectiveness in COVID-19 patients.
Synonyms:exact_synonym: 4-{2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl}phenyl 4-carbamimidamidobenzoate
 related_synonym: 4-{2-[(dimethylcarbamoyl)methoxy]-2-oxoethyl}phenyl 4-carbamimidamidobenzoate;   Formula=C20H22N4O5;   InChI=1S/C20H22N4O5/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22/h3-10H,11-12H2,1-2H3,(H4,21,22,23);   InChIKey=XASIMHXSUQUHLV-UHFFFAOYSA-N;   N,N-dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)phenylacetate;   SMILES=CN(C)C(=O)COC(=O)CC1=CC=C(OC(=O)C2=CC=C(NC(N)=N)C=C2)C=C1;   camostatum
 xref: CAS:59721-28-7;   Chemspider:2440;   DrugBank:DB13729;   Drug_Central:471;   KEGG:D07606
 xref_mesh: MESH:C034532
 xref: PMCID:PMC7809394;   PMID:23412700;   PMID:26166259;   PMID:26887332;   PMID:33176395;   PMID:33225308;   PMID:33505639;   PMID:33564221;   PMID:33676899;   PMID:7341342;   Wikipedia:Camostat
 cyclic_relationship: is_conjugate_base_of CHEBI:169939


show annotations for term's descendants           Sort by:
camostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cckar cholecystokinin A receptor increases expression EXP camostat results in increased expression of CCKAR mRNA CTD PMID:10458643 NCBI chr14:57,292,397...57,300,747
Ensembl chr14:57,292,397...57,300,747 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP camostat inhibits the reaction [PLG protein modified form results in increased expression of CCL2 mRNA] CTD PMID:27773435 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of CCN2 mRNA]; camostat inhibits the reaction [PLG protein modified form results in increased expression of CCN2 mRNA] CTD PMID:25766432 PMID:27773435 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression 		ISO mirdametinib inhibits the reaction [camostat results in increased expression of CCND1 protein] CTD PMID:25104499 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd3 cyclin D3 multiple interactions
increases expression 		ISO mirdametinib inhibits the reaction [camostat results in increased expression of CCND3 protein] CTD PMID:25104499 NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Ccne1 cyclin E1 increases expression
multiple interactions 		ISO camostat results in increased expression of CCNE1 protein
mirdametinib inhibits the reaction [camostat results in increased expression of CCNE1 protein] 		CTD PMID:25104499 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of COL1A1 mRNA] CTD PMID:25766432 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of COL3A1 mRNA] CTD PMID:25766432 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of CYBB mRNA] CTD PMID:25766432 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression 		ISO mirdametinib inhibits the reaction [camostat results in increased expression of EGR1 mRNA] CTD PMID:25104499 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Fgf21 fibroblast growth factor 21 multiple interactions ISO camostat results in increased expression of and results in increased secretion of FGF21 protein CTD PMID:30920846 NCBI chr 1:105,219,825...105,221,376
Ensembl chr 1:96,083,441...96,090,454 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression 		ISO mirdametinib inhibits the reaction [camostat results in increased expression of FOS mRNA] CTD PMID:25104499 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Ier3 immediate early response 3 increases expression ISO camostat results in increased expression of IER3 mRNA CTD PMID:25104499 NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,928,378...2,929,583 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
increases phosphorylation 		ISO camostat results in increased expression of JUN mRNA
camostat results in increased phosphorylation of JUN protein 		CTD PMID:25104499 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO camostat results in increased expression of JUNB mRNA CTD PMID:25104499 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation 		ISO mirdametinib inhibits the reaction [camostat results in increased phosphorylation of MAPK1 protein]; trametinib inhibits the reaction [camostat results in increased phosphorylation of MAPK1 protein] CTD PMID:25104499 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions 		ISO camostat results in increased phosphorylation of MAPK3 protein
mirdametinib inhibits the reaction [camostat results in increased phosphorylation of MAPK3 protein]; trametinib inhibits the reaction [camostat results in increased phosphorylation of MAPK3 protein] 		CTD PMID:25104499 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression
multiple interactions 		ISO camostat results in increased expression of MKI67 protein
mirdametinib inhibits the reaction [camostat results in increased expression of MKI67 protein] 		CTD PMID:25104499 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression EXP camostat results in increased expression of NOS3 mRNA CTD PMID:10458643 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of NOX1 mRNA] CTD PMID:25766432 NCBI chr  X:101,572,338...101,625,571
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression 		ISO mirdametinib inhibits the reaction [camostat results in increased expression of PCNA protein] CTD PMID:25104499 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Plg plasminogen decreases activity
multiple interactions 		EXP camostat results in decreased activity of PLG protein modified form
camostat inhibits the reaction [PLG protein modified form results in increased expression of CCL2 mRNA]; camostat inhibits the reaction [PLG protein modified form results in increased expression of CCN2 mRNA]; camostat inhibits the reaction [PLG protein modified form results in increased expression of TGFB1 mRNA]; camostat inhibits the reaction [PLG protein modified form results in increased expression of TNF mRNA] 		CTD PMID:27773435 NCBI chr 1:50,872,927...50,915,406
Ensembl chr 1:48,325,185...48,367,786 		JBrowse link
G Rps6 ribosomal protein S6 increases phosphorylation ISO camostat results in increased phosphorylation of RPS6 protein CTD PMID:25104499 NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP camostat inhibits the reaction [Adenine results in increased expression of SERPINE1 mRNA] CTD PMID:25766432 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO camostat inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD2 protein] CTD PMID:26599507 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation ISO camostat results in increased phosphorylation of STAT3 protein CTD PMID:25104499 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP 		camostat inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]
camostat inhibits the reaction [Adenine results in increased expression of TGFB1 mRNA]; camostat inhibits the reaction [PLG protein modified form results in increased expression of TGFB1 mRNA] 		CTD PMID:25766432 PMID:26599507 PMID:27773435 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP 		camostat inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
camostat inhibits the reaction [PLG protein modified form results in increased expression of TNF mRNA] 		CTD PMID:20023007 PMID:27773435 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      application 20617
        anti-inflammatory agent 16836
          camostat 28
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            heteroorganic entity 20215
                              organochalcogen compound 19902
                                organooxygen compound 19804
                                  carbon oxoacid 19150
                                    carboxylic acid 19147
                                      carboacyl group 18082
                                        univalent carboacyl group 18082
                                          carbamoyl group 17918
                                            carboxamide 17918
                                              tertiary carboxamide 862
                                                camostat 28
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