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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:rimexolone
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Accession:CHEBI:135566 term browser browse the term
Synonyms:related_synonym: Formula=C24H34O3;   InChI=1S/C24H34O3/c1-6-20(27)24(5)14(2)11-18-17-8-7-15-12-16(25)9-10-22(15,3)21(17)19(26)13-23(18,24)4/h9-10,12,14,17-19,21,26H,6-8,11,13H2,1-5H3/t14-,17+,18+,19+,21-,22+,23+,24-/m1/s1;   InChIKey=QTTRZHGPGKRAFB-OOKHYKNYSA-N;   SMILES=C[C@@]12[C@]([C@]3([C@]([C@H](C1)O)([C@]4(C)C(CC3)=CC(C=C4)=O)[H])[H])(C[C@H]([C@@]2(C(CC)=O)C)C)[H];   rimexel;   trimexolone
 xref: CAS:49697-38-3;   Drug_Central:2384
 xref_mesh: MESH:C013769



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rimexolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd28 Cd28 molecule multiple interactions ISO [rimexolone co-treated with CD28 protein] results in increased expression of NFKBIA mRNA; Mifepristone inhibits the reaction [[rimexolone co-treated with CD28 protein] results in increased expression of NFKBIA mRNA]; Mifepristone inhibits the reaction [rimexolone inhibits the reaction [CD28 protein results in increased secretion of IFNG protein]]; Mifepristone inhibits the reaction [rimexolone inhibits the reaction [CD28 protein results in increased secretion of IL2 protein]]; Mifepristone inhibits the reaction [rimexolone inhibits the reaction [CD28 protein results in increased secretion of TNF protein]]; rimexolone inhibits the reaction [CD28 protein results in increased secretion of IFNG protein]; rimexolone inhibits the reaction [CD28 protein results in increased secretion of IL2 protein]; rimexolone inhibits the reaction [CD28 protein results in increased secretion of TNF protein] CTD PMID:20363256 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
JBrowse link
G Cd4 Cd4 molecule multiple interactions
decreases expression
ISO Mifepristone inhibits the reaction [rimexolone results in decreased expression of CD4 protein] CTD PMID:20363256 NCBI chr 4:157,668,878...157,695,366 JBrowse link
G Ifng interferon gamma multiple interactions ISO Mifepristone inhibits the reaction [rimexolone inhibits the reaction [CD28 protein results in increased secretion of IFNG protein]]; rimexolone inhibits the reaction [CD28 protein results in increased secretion of IFNG protein] CTD PMID:20363256 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Mifepristone inhibits the reaction [rimexolone inhibits the reaction [CD28 protein results in increased secretion of IL2 protein]]; rimexolone inhibits the reaction [CD28 protein results in increased secretion of IL2 protein] CTD PMID:20363256 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases expression
ISO [rimexolone co-treated with CD28 protein] results in increased expression of NFKBIA mRNA; Mifepristone inhibits the reaction [[rimexolone co-treated with CD28 protein] results in increased expression of NFKBIA mRNA]
rimexolone results in increased expression of NFKBIA protein
CTD PMID:20363256 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Mifepristone inhibits the reaction [rimexolone inhibits the reaction [CD28 protein results in increased secretion of TNF protein]]; rimexolone inhibits the reaction [CD28 protein results in increased secretion of TNF protein] CTD PMID:20363256 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20057
    chemical entity 20068
      group 19989
        inorganic group 19526
          oxo group 18923
            organic oxo compound 18923
              carbonyl compound 18923
                ketone 17102
                  oxo steroid 10319
                    20-oxo steroid 7343
                      rimexolone 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 20057
    subatomic particle 20056
      composite particle 20068
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19971
                    p-block element atom 19971
                      carbon group element atom 19889
                        carbon atom 19894
                          organic molecular entity 19882
                            organic group 18982
                              organic divalent group 18968
                                organodiyl group 18968
                                  carbonyl group 18923
                                    carbonyl compound 18923
                                      ketone 17102
                                        oxo steroid 10319
                                          20-oxo steroid 7343
                                            rimexolone 6
paths to the root