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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:rimexolone
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Accession:CHEBI:135566 term browser browse the term
Synonyms:related_synonym: Formula=C24H34O3;   InChI=1S/C24H34O3/c1-6-20(27)24(5)14(2)11-18-17-8-7-15-12-16(25)9-10-22(15,3)21(17)19(26)13-23(18,24)4/h9-10,12,14,17-19,21,26H,6-8,11,13H2,1-5H3/t14-,17+,18+,19+,21-,22+,23+,24-/m1/s1;   InChIKey=QTTRZHGPGKRAFB-OOKHYKNYSA-N;   SMILES=C[C@@]12[C@]([C@]3([C@]([C@H](C1)O)([C@]4(C)C(CC3)=CC(C=C4)=O)[H])[H])(C[C@H]([C@@]2(C(CC)=O)C)C)[H];   rimexel;   trimexolone
 xref: CAS:49697-38-3;   Drug_Central:2384
 xref_mesh: MESH:C013769



show annotations for term's descendants           Sort by:
rimexolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd28 Cd28 molecule multiple interactions ISO [rimexolone co-treated with CD28 protein] results in increased expression of NFKBIA mRNA; Mifepristone inhibits the reaction [[rimexolone co-treated with CD28 protein] results in increased expression of NFKBIA mRNA]; Mifepristone inhibits the reaction [rimexolone inhibits the reaction [CD28 protein results in increased secretion of IFNG protein]]; Mifepristone inhibits the reaction [rimexolone inhibits the reaction [CD28 protein results in increased secretion of IL2 protein]]; Mifepristone inhibits the reaction [rimexolone inhibits the reaction [CD28 protein results in increased secretion of TNF protein]]; rimexolone inhibits the reaction [CD28 protein results in increased secretion of IFNG protein]; rimexolone inhibits the reaction [CD28 protein results in increased secretion of IL2 protein]; rimexolone inhibits the reaction [CD28 protein results in increased secretion of TNF protein] CTD PMID:20363256 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
JBrowse link
G Cd4 Cd4 molecule multiple interactions
decreases expression
ISO Mifepristone inhibits the reaction [rimexolone results in decreased expression of CD4 protein] CTD PMID:20363256 NCBI chr 4:157,668,878...157,695,366 JBrowse link
G Ifng interferon gamma multiple interactions ISO Mifepristone inhibits the reaction [rimexolone inhibits the reaction [CD28 protein results in increased secretion of IFNG protein]]; rimexolone inhibits the reaction [CD28 protein results in increased secretion of IFNG protein] CTD PMID:20363256 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Mifepristone inhibits the reaction [rimexolone inhibits the reaction [CD28 protein results in increased secretion of IL2 protein]]; rimexolone inhibits the reaction [CD28 protein results in increased secretion of IL2 protein] CTD PMID:20363256 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases expression
ISO [rimexolone co-treated with CD28 protein] results in increased expression of NFKBIA mRNA; Mifepristone inhibits the reaction [[rimexolone co-treated with CD28 protein] results in increased expression of NFKBIA mRNA]
rimexolone results in increased expression of NFKBIA protein
CTD PMID:20363256 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Mifepristone inhibits the reaction [rimexolone inhibits the reaction [CD28 protein results in increased secretion of TNF protein]]; rimexolone inhibits the reaction [CD28 protein results in increased secretion of TNF protein] CTD PMID:20363256 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    chemical entity 19916
      group 19875
        inorganic group 19454
          oxo group 18922
            organic oxo compound 18922
              carbonyl compound 18922
                ketone 17210
                  oxo steroid 10546
                    20-oxo steroid 7674
                      rimexolone 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      ketone 17210
                                        oxo steroid 10546
                                          20-oxo steroid 7674
                                            rimexolone 6
paths to the root