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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nafamostat
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Accession:CHEBI:135466 term browser browse the term
Synonyms:related_synonym: FUT-175;   Formula=C19H17N5O2;   InChI=1S/C19H17N5O2/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23/h1-10H,(H3,20,21)(H4,22,23,24);   InChIKey=MQQNFDZXWVTQEH-UHFFFAOYSA-N;   SMILES=C(=N)(N)C1=CC=2C(C=C1)=CC(=CC2)OC(=O)C3=CC=C(C=C3)NC(=N)N;   nafamostat HCl;   nafamostat dihydrochloride;   nafamostat hydrochloride;   nafamostat mesilate;   nafamostat mesylate;   nafamstat;   ronastat
 xref: CAS:81525-10-2;   Drug_Central:1867
 xref_mesh: MESH:C032855


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nafamostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asic5 acid sensing ion channel subunit family member 5 decreases activity EXP
ISO
nafamostat results in decreased activity of ASIC5 protein CTD PMID:21828194 NCBI chr 2:180,935,392...180,964,365
Ensembl chr 2:180,936,688...180,964,365
JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase multiple interactions ISO nafamostat binds to and results in decreased activity of FTO protein CTD PMID:30393114 NCBI chr19:16,774,549...17,115,098
Ensembl chr19:16,772,744...17,115,113
JBrowse link
G Kng2 kininogen 2 multiple interactions ISO nafamostat inhibits the reaction [[Propofol co-treated with Pharmaceutical Vehicles] results in increased expression of KNG1 protein modified form] CTD PMID:10655909 NCBI chr11:81,509,185...81,516,759 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19817
    chemical entity 19817
      atom 19815
        nonmetal atom 19694
          nitrogen atom 18602
            nitrogen molecular entity 18602
              organonitrogen compound 18379
                guanidines 2182
                  nafamostat 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19817
    subatomic particle 19815
      composite particle 19815
        hadron 19815
          baryon 19815
            nucleon 19815
              atomic nucleus 19815
                atom 19815
                  main group element atom 19705
                    p-block element atom 19705
                      carbon group element atom 19614
                        carbon atom 19603
                          organic molecular entity 19603
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18435
                                    carbonyl compound 18435
                                      carboxylic acid 18113
                                        aromatic carboxylic acid 10914
                                          benzoic acids 10883
                                            nafamostat 3
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