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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nafamostat
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Accession:CHEBI:135466 term browser browse the term
Synonyms:related_synonym: FUT-175;   Formula=C19H17N5O2;   InChI=1S/C19H17N5O2/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23/h1-10H,(H3,20,21)(H4,22,23,24);   InChIKey=MQQNFDZXWVTQEH-UHFFFAOYSA-N;   SMILES=C(=N)(N)C1=CC=2C(C=C1)=CC(=CC2)OC(=O)C3=CC=C(C=C3)NC(=N)N;   nafamostat HCl;   nafamostat dihydrochloride;   nafamostat hydrochloride;   nafamostat mesilate;   nafamostat mesylate;   nafamstat;   ronastat
 xref: CAS:81525-10-2;   Drug_Central:1867
 xref_mesh: MESH:C032855


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nafamostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asic5 acid sensing ion channel subunit family member 5 decreases activity EXP
ISO
nafamostat results in decreased activity of ASIC5 protein CTD PMID:21828194 NCBI chr 2:180,935,392...180,964,365
Ensembl chr 2:180,936,688...180,964,365
JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase multiple interactions ISO nafamostat binds to and results in decreased activity of FTO protein CTD PMID:30393114 NCBI chr19:16,774,549...17,115,098
Ensembl chr19:16,772,744...17,115,113
JBrowse link
G Kng2 kininogen 2 multiple interactions ISO nafamostat inhibits the reaction [[Propofol co-treated with Pharmaceutical Vehicles] results in increased expression of KNG1 protein modified form] CTD PMID:10655909 NCBI chr11:81,509,185...81,516,759 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    chemical entity 19875
      atom 19873
        nonmetal atom 19751
          nitrogen atom 18640
            nitrogen molecular entity 18640
              organonitrogen compound 18414
                guanidines 2174
                  nafamostat 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic group 18569
                              organic divalent group 18560
                                organodiyl group 18560
                                  carbonyl group 18468
                                    carbonyl compound 18468
                                      carboxylic acid 18142
                                        aromatic carboxylic acid 10919
                                          benzoic acids 10888
                                            nafamostat 3
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