CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: reboxetine
Accession: CHEBI:135342
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Synonyms: related_synonym: Formula=C19H23NO3; InChI=1S/C19H23NO3/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18/h3-11,18-20H,2,12-14H2,1H3/t18-,19-/m1/s1; InChIKey=CBQGYUDMJHNJBX-RTBURBONSA-N; SMILES=[C@](OC1=C(OCC)C=CC=C1)(C2=CC=CC=C2)([C@]3(CNCCO3)[H])[H]; edronax; norebox; reboxetine mesilate; reboxetine mesylate; reboxitine
xref: CAS:71620-89-8; Drug_Central:2361
xref_mesh: MESH:C074679
G
Agt
angiotensinogen
decreases expression
ISO
reboxetine results in decreased expression of AGT protein modified form
CTD
PMID:16717144
NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
G
Dbh
dopamine beta-hydroxylase
increases response to substance
ISO
DBH protein results in increased susceptibility to reboxetine
CTD
PMID:15148402
NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
EXP
reboxetine results in increased expression of FOS protein
CTD
PMID:15609068
NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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Ntrk2
neurotrophic receptor tyrosine kinase 2
multiple interactions
ISO
reboxetine results in increased phosphorylation of and results in increased activity of NTRK2 protein
CTD
PMID:21666748
NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
G
Ren
renin
decreases activity
ISO
reboxetine results in decreased activity of REN protein
CTD
PMID:16717144
NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
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Slc6a2
solute carrier family 6 member 2
decreases expression
ISO
reboxetine results in decreased expression of SLC6A2 protein
CTD
PMID:18923402
NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274
G
Slc6a3
solute carrier family 6 member 3
affects response to substance
ISO
SLC6A3 protein affects the susceptibility to reboxetine
CTD
PMID:11312315
NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
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