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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:reboxetine
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Accession:CHEBI:135342 term browser browse the term
Synonyms:related_synonym: Formula=C19H23NO3;   InChI=1S/C19H23NO3/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18/h3-11,18-20H,2,12-14H2,1H3/t18-,19-/m1/s1;   InChIKey=CBQGYUDMJHNJBX-RTBURBONSA-N;   SMILES=[C@](OC1=C(OCC)C=CC=C1)(C2=CC=CC=C2)([C@]3(CNCCO3)[H])[H];   edronax;   norebox;   reboxetine mesilate;   reboxetine mesylate;   reboxitine
 xref: CAS:71620-89-8;   Drug_Central:2361
 xref_mesh: MESH:C074679


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reboxetine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen decreases expression ISO reboxetine results in decreased expression of AGT protein modified form CTD PMID:16717144 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Dbh dopamine beta-hydroxylase increases response to substance ISO DBH protein results in increased susceptibility to reboxetine CTD PMID:15148402 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP reboxetine results in increased expression of FOS protein CTD PMID:15609068 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO reboxetine results in increased phosphorylation of and results in increased activity of NTRK2 protein CTD PMID:21666748 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Ren renin decreases activity ISO reboxetine results in decreased activity of REN protein CTD PMID:16717144 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Slc6a2 solute carrier family 6 member 2 decreases expression ISO reboxetine results in decreased expression of SLC6A2 protein CTD PMID:18923402 NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274
JBrowse link
G Slc6a3 solute carrier family 6 member 3 affects response to substance ISO SLC6A3 protein affects the susceptibility to reboxetine CTD PMID:11312315 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19841
      group 19755
        polyatomic entity 19754
          molecule 19587
            organic molecule 19556
              organic cyclic compound 19365
                organic aromatic compound 19192
                  aromatic ether 15567
                    reboxetine 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    main group molecular entity 19732
                      p-block molecular entity 19732
                        carbon group molecular entity 19636
                          organic molecular entity 19625
                            heteroorganic entity 19217
                              organochalcogen compound 18922
                                organooxygen compound 18846
                                  ether 16086
                                    aromatic ether 15567
                                      reboxetine 7
paths to the root