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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:guggulsterone
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Accession:CHEBI:135338 term browser browse the term
Synonyms:related_synonym: Formula=C21H28O2;   InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/t15-,17+,18+,20+,21-/m1/s1;   InChIKey=WDXRGPWQVHZTQJ-NRJJLHBYSA-N;   SMILES=C[C@@]12[C@]([C@]3([C@](CC1)([C@]4(C)C(CC3)=CC(CC4)=O)[H])[H])(CC(C2=CC)=O)[H];   Z/E-Guggulsterone
 xref: CAS:95975-55-6;   Drug_Central:3953
 xref_mesh: MESH:C023617


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guggulsterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
increases expression
ISO
EXP
[pregna-4,17-diene-3,16-dione co-treated with Chenodeoxycholic Acid] results in increased expression of ABCB11 mRNA; [pregna-4,17-diene-3,16-dione co-treated with GW 4064] results in increased expression of ABCB11 mRNA; pregna-4,17-diene-3,16-dione inhibits the reaction [Bile Acids and Salts results in increased expression of ABCB11 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [NR1H4 protein results in increased expression of ABCB11 mRNA]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Abcb11 protein in liver]]
pregna-4,17-diene-3,16-dione inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]]
pregna-4,17-diene-3,16-dione results in increased expression of ABCB11 mRNA
CTD PMID:12525500 PMID:12705905 PMID:25655198 PMID:29660435, PMID:27939985 RGD:15036816 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB4 mRNA]] CTD PMID:25655198 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]] CTD PMID:25655198 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACACA protein]] CTD PMID:27773935 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acads acyl-CoA dehydrogenase short chain multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of ACADS mRNA]] CTD PMID:27773935 NCBI chr12:47,254,503...47,263,747
Ensembl chr12:47,254,484...47,263,747
JBrowse link
G Acly ATP citrate lyase multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [Palmitic Acid results in increased expression of ACLY mRNA] CTD PMID:31421115 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA] CTD PMID:15322087 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BCL2A1 mRNA] CTD PMID:15322087 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage ISO pregna-4,17-diene-3,16-dione results in increased cleavage of BID protein CTD PMID:17475222 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA] CTD PMID:15322087 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BIRC5 mRNA] CTD PMID:15322087 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Casp3 caspase 3 increases activity ISO pregna-4,17-diene-3,16-dione results in increased activity of CASP3 protein CTD PMID:17475222 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO pregna-4,17-diene-3,16-dione results in increased activity of CASP8 protein CTD PMID:17475222 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity ISO pregna-4,17-diene-3,16-dione results in increased activity of CASP9 protein CTD PMID:17475222 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cbr3 carbonyl reductase 3 increases expression ISO pregna-4,17-diene-3,16-dione results in increased expression of CBR3 mRNA CTD PMID:20806931 NCBI chr11:33,909,417...33,917,674
Ensembl chr11:33,909,439...33,917,674
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CCNB1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCNB1 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCNB1 protein]] CTD PMID:29660435 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO pregna-4,17-diene-3,16-dione results in decreased expression of CCND1 protein
pregna-4,17-diene-3,16-dione inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CCND1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCND1 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCND1 protein]]
pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]
CTD PMID:15322087 PMID:17475222 PMID:29660435 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO pregna-4,17-diene-3,16-dione results in decreased expression of CDK1 protein CTD PMID:17475222 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO pregna-4,17-diene-3,16-dione results in increased expression of CDKN1A protein CTD PMID:17475222 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO pregna-4,17-diene-3,16-dione results in increased expression of CDKN1B protein CTD PMID:17475222 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA] CTD PMID:15322087 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO
EXP
pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of CPT1A mRNA]]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of CPT1a mRNA and protein in liver]]
CTD PMID:27773935, PMID:27939985 RGD:15036816 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cyc1 cytochrome c-1 affects localization ISO pregna-4,17-diene-3,16-dione affects the localization of CYC1 protein CTD PMID:17475222 NCBI chr 7:117,409,576...117,411,953
Ensembl chr 7:117,409,576...117,411,953
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects expression ISO pregna-4,17-diene-3,16-dione affects the expression of CYP2B10 mRNA CTD PMID:15833898 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO
EXP
pregna-4,17-diene-3,16-dione inhibits the reaction [NR1I2 protein results in increased expression of CYP7A1 mRNA]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol increases expression of Cyp7a1 protein in liver]]
pregna-4,17-diene-3,16-dione inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 protein]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]]
CTD PMID:12705905 PMID:25655198 PMID:29660435, PMID:27939985 RGD:15036816 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP8B1 protein]] CTD PMID:25655198 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression ISO pregna-4,17-diene-3,16-dione results in decreased expression of DNMT1 mRNA; pregna-4,17-diene-3,16-dione results in decreased expression of DNMT1 protein CTD PMID:23593078 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha decreases expression ISO pregna-4,17-diene-3,16-dione results in decreased expression of DNMT3A mRNA CTD PMID:23593078 NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta decreases expression ISO pregna-4,17-diene-3,16-dione results in decreased expression of DNMT3B mRNA CTD PMID:23593078 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
decreases expression
ISO Calcitriol promotes the reaction [pregna-4,17-diene-3,16-dione results in decreased expression of FABP4 protein]; pregna-4,17-diene-3,16-dione promotes the reaction [Calcitriol results in decreased expression of FABP4 protein] CTD PMID:17959142 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol increases expression of Fas mRNA and protein in liver]] RGD PMID:27939985 RGD:15036816 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of FASN protein]] CTD PMID:27773935 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fgf19 fibroblast growth factor 19 multiple interactions EXP Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of FGF19 protein in liver and intestine]] RGD PMID:27939985 RGD:15036816 NCBI chr 1:218,058,405...218,061,693
Ensembl chr 1:218,058,405...218,061,693
JBrowse link
G Foxm1 forkhead box M1 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of FOXM1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of FOXM1 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of FOXM1 protein]] CTD PMID:29660435 NCBI chr 4:161,685,236...161,697,633
Ensembl chr 4:161,685,258...161,696,305
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO pregna-4,17-diene-3,16-dione results in increased expression of GCLC mRNA CTD PMID:22851183 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO pregna-4,17-diene-3,16-dione results in increased expression of GCLM mRNA CTD PMID:22851183 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO pregna-4,17-diene-3,16-dione results in decreased expression of HDAC1 protein CTD PMID:23593078 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [IL1B protein results in increased activity of RELA protein]
pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA]]; pregna-4,17-diene-3,16-dione promotes the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA]
CTD PMID:15322087 PMID:29660435 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of LPL mRNA]] CTD PMID:27773935 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Lrp2 LDL receptor related protein 2 multiple interactions
increases expression
ISO NR1H4 protein promotes the reaction [pregna-4,17-diene-3,16-dione results in increased expression of LRP2 protein] CTD PMID:15375181 NCBI chr 3:55,665,153...55,822,484
Ensembl chr 3:55,665,145...55,822,551
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity ISO pregna-4,17-diene-3,16-dione results in increased activity of MAPK8 protein CTD PMID:17475222 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mecp2 methyl CpG binding protein 2 decreases expression ISO pregna-4,17-diene-3,16-dione results in decreased expression of MECP2 protein CTD PMID:23593078 NCBI chr  X:156,650,389...156,713,813
Ensembl chr  X:156,655,960...156,705,233
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA] CTD PMID:15322087 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of MYC mRNA] CTD PMID:15322087 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]; pregna-4,17-diene-3,16-dione promotes the reaction [NR1I2 protein binds to NCOA1 protein] CTD PMID:15833898 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to pregna-4,17-diene-3,16-dione CTD PMID:22851183 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO
EXP
pregna-4,17-diene-3,16-dione inhibits the reaction [Hydrogen Peroxide results in increased activity of NFKB1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [Okadaic Acid results in increased activity of NFKB1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of NFKB1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]
Z-guggulsterone prevents the reaction [Dihydroartemisinin inhibits the reaction [ethanol increases expression of Nf-kB protein in liver]]
CTD PMID:15322087, PMID:27939985 RGD:15036816 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP
pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Nfkbia protein in liver]]
CTD PMID:15322087, PMID:27939985 RGD:15036816 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol increases expression of Nrlp3 protein in liver]] RGD PMID:27939985 RGD:15036816 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO pregna-4,17-diene-3,16-dione results in increased expression of NQO1 mRNA CTD PMID:22851183 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO
EXP
pregna-4,17-diene-3,16-dione inhibits the reaction [Imatinib Mesylate results in increased expression of NR0B2 mRNA]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Nr0b2 protein in liver and intestine]]
pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]]
CTD PMID:22414727 PMID:25655198, PMID:27939985 RGD:15036816 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions ISO pregna-4,17-diene-3,16-dione promotes the reaction [Palmitic Acid results in decreased expression of NR1H2 mRNA] CTD PMID:31421115 NCBI chr 1:100,554,577...100,559,896
Ensembl chr 1:100,554,544...100,559,942
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
decreases expression
decreases activity
ISO
EXP
2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; 22,23-dihydroavermectin B(1)a inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; abamectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Albendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; albendazole sulfoxide inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; alvocidib inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Apigenin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; benidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Benomyl inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; bifenthrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; biochanin A inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Bortezomib inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; carbendazim inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; chrysin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; ciclobendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; cilnidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Colchicine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; cyfluthrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; cyhalothrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; cypermethrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Dactinomycin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Daunorubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; decamethrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Digoxin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; diphenadione inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Dipyridamole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Docetaxel inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; doramectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Doxorubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; emamectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Emetine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; enzastaurin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Epirubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Estradiol inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Ethacridine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Ethinyl Estradiol inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Ethylestrenol inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Fenbendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; fenvalerate inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; flucythrinate inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; fluvalinate inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Fulvestrant inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Genistein inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Griseofulvin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Idarubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Isotretinoin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; kadethrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; lacidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; lercanidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Lithocholic Acid inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; manidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Mebendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; methoxy-morpholinyl-doxorubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Mitomycin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; moxidectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Nicardipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Nifedipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Nimodipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Nisoldipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Nocodazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; NR1H4 protein promotes the reaction [pregna-4,17-diene-3,16-dione results in increased abundance of Lipids]; oxfendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; oxibendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; parbendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; phenothrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; picropodophyllin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; pirarubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Podophyllotoxin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; pregna-4,17-diene-3,16-dione inhibits the reaction [Imatinib Mesylate results in increased activity of NR1H4 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [NR1H4 protein results in increased expression of ABCB11 mRNA]; Proflavine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; selamectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Simendan inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; ST 1481 inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; surinabant inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Tretinoin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Ursodeoxycholic Acid inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Vinblastine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Vincristine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Vinorelbine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Nr1h4 mRNA and protein in liver and liver cell nuclei and intestine]]
guggulsterone decreases expression of nr1h4 mRNA in rat embryonic liver cells
NR1H4 protein promotes the reaction [pregna-4,17-diene-3,16-dione results in increased expression of LRP2 protein]; pregna-4,17-diene-3,16-dione binds to and results in decreased activity of NR1H4 protein; pregna-4,17-diene-3,16-dione promotes the reaction [Palmitic Acid results in decreased expression of NR1H4 mRNA]
CTD PMID:12705905 PMID:15375181 PMID:20079722 PMID:22414727 PMID:25257666 PMID:27773686 PMID:31421115, PMID:27939985, PMID:29235094 RGD:15036816, RGD:15042872 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
decreases expression
increases activity
decreases activity
ISO pregna-4,17-diene-3,16-dione inhibits the reaction [NR1I2 protein results in increased expression of CYP7A1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [Thapsigargin results in decreased expression of NR1I2 mRNA]
pregna-4,17-diene-3,16-dione results in decreased expression of NR1I2 mRNA
pregna-4,17-diene-3,16-dione results in increased activity of NR1I2 protein
pregna-4,17-diene-3,16-dione promotes the reaction [NR1I2 protein binds to NCOA1 protein]
pregna-4,17-diene-3,16-dione results in decreased activity of NR1I2 protein
CTD PMID:12705905 PMID:15075359 PMID:15833898 PMID:25616597 PMID:29933105 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO pregna-4,17-diene-3,16-dione binds to and results in decreased activity of NR1I3 protein; pregna-4,17-diene-3,16-dione inhibits the reaction [NR1I3 protein binds to NCOA1 protein] CTD PMID:15833898 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO
EXP
pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of PPARA mRNA]]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Ppara mRNA and protein in liver]]
CTD PMID:27773935, PMID:27939985 RGD:15036816 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA] CTD PMID:15322087 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [Hydrogen Peroxide results in increased activity of RELA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [IL1B protein results in increased activity of RELA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [Okadaic Acid results in increased activity of RELA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased activity of RELA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]
pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of RELA mRNA]]; pregna-4,17-diene-3,16-dione promotes the reaction [1-Naphthylisothiocyanate results in increased expression of RELA mRNA]
CTD PMID:15322087 PMID:29660435 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SCD1 protein]]; pregna-4,17-diene-3,16-dione inhibits the reaction [Palmitic Acid results in increased expression of SCD1 mRNA] CTD PMID:27773935 PMID:31421115 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO
EXP
pregna-4,17-diene-3,16-dione inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol decreases expression of Slc10a1 protein in liver]]
CTD PMID:25655198 PMID:29660435, PMID:27939985 RGD:15036816 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO
EXP
pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 protein]]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol increases expression of Srebf1 mRNA and protein in liver]]
CTD PMID:27773935, PMID:27939985 RGD:15036816 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases activity
ISO
EXP
pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased activity of RELA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BCL2A1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BIRC5 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of MYC mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of TRAF1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
Z-guggulsterone reverses the reaction [Dihydroartemisinin inhibits the reaction [ethanol increases expression of Tnf protein in liver]]
pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF mRNA]]; pregna-4,17-diene-3,16-dione promotes the reaction [1-Naphthylisothiocyanate results in increased expression of TNF mRNA]
pregna-4,17-diene-3,16-dione results in increased activity of TNF protein
CTD PMID:15322087 PMID:29660435, PMID:27939985 RGD:15036816 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Traf1 TNF receptor-associated factor 1 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of TRAF1 mRNA] CTD PMID:15322087 NCBI chr 3:14,003,340...14,022,955
Ensembl chr 3:14,003,340...14,022,672
JBrowse link
G Vdr vitamin D receptor multiple interactions ISO pregna-4,17-diene-3,16-dione promotes the reaction [Calcitriol results in increased expression of VDR protein] CTD PMID:17959142 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA] CTD PMID:15322087 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of XIAP mRNA] CTD PMID:15322087 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19767
    role 19714
      biological role 19714
        molecular messenger 18300
          hormone 18071
            sex hormone 17968
              androgen 4657
                guggulsterone 67
Path 2
Term Annotations click to browse term
  CHEBI ontology 19767
    subatomic particle 19766
      composite particle 19766
        hadron 19766
          baryon 19766
            nucleon 19766
              atomic nucleus 19766
                atom 19766
                  main group element atom 19657
                    p-block element atom 19657
                      carbon group element atom 19573
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19496
                              organic cyclic compound 19322
                                organic polycyclic compound 16514
                                  steroid 13054
                                    hydroxy steroid 12652
                                      3-hydroxy steroid 10360
                                        guggulsterone 67
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