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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mabuterol
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Accession:CHEBI:135325 term browser browse the term
Synonyms:related_synonym: Formula=C13H18ClF3N2O;   InChI=1S/C13H18ClF3N2O/c1-12(2,3)19-6-10(20)7-4-8(13(15,16)17)11(18)9(14)5-7/h4-5,10,19-20H,6,18H2,1-3H3;   InChIKey=JSJCTEKTBOKRST-UHFFFAOYSA-N;   SMILES=C(F)(F)(F)C1=CC(C(CNC(C)(C)C)O)=CC(=C1N)Cl;   ambuterol;   broncholin;   mabuterol HCl;   mabuterol hydrochloride
 xref: CAS:56341-08-3;   Drug_Central:1623
 xref_mesh: MESH:C044573


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mabuterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd1 cyclin D1 multiple interactions EXP [mabuterol co-treated with 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone] inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of CCND1 protein]; mabuterol inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of CCND1 protein] CTD PMID:31009640 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Dnm1l dynamin 1-like multiple interactions EXP [mabuterol co-treated with 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone] inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of DNM1L mRNA]; [mabuterol co-treated with 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone] inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of DNM1L protein]; mabuterol inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of DNM1L mRNA]; mabuterol inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of DNM1L protein] CTD PMID:31009640 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP [mabuterol co-treated with 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone] inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in decreased expression of MFN2 mRNA]; [mabuterol co-treated with 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone] inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in decreased expression of MFN2 protein]; mabuterol inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in decreased expression of MFN2 mRNA]; mabuterol inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in decreased expression of MFN2 protein] CTD PMID:31009640 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [mabuterol co-treated with 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone] inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of PCNA protein]; mabuterol inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of PCNA protein] CTD PMID:31009640 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions EXP [mabuterol co-treated with 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone] inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in decreased expression of MFN2 mRNA]; [mabuterol co-treated with 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone] inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in decreased expression of MFN2 protein]; [mabuterol co-treated with 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone] inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of CCND1 protein]; [mabuterol co-treated with 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone] inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of DNM1L mRNA]; [mabuterol co-treated with 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone] inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of DNM1L protein]; [mabuterol co-treated with 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone] inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of PCNA protein]; mabuterol inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in decreased expression of MFN2 mRNA]; mabuterol inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in decreased expression of MFN2 protein]; mabuterol inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of CCND1 protein]; mabuterol inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of DNM1L mRNA]; mabuterol inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of DNM1L protein]; mabuterol inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of PCNA protein] CTD PMID:31009640 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        refrigerant 17418
          tetrafluoromethane 6329
            trifluoromethyl group 6329
              (trifluoromethyl)benzenes 6329
                mabuterol 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            organic hydride 18248
                              organic fundamental parent 18248
                                hydrocarbon 17968
                                  halohydrocarbon 13938
                                    haloalkane 11658
                                      fluoroalkane 7109
                                        fluoromethanes 6329
                                          tetrafluoromethane 6329
                                            trifluoromethyl group 6329
                                              (trifluoromethyl)benzenes 6329
                                                mabuterol 5
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.