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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gestodene
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Accession:CHEBI:135323 term browser browse the term
Synonyms:related_synonym: Formula=C21H26O2;   InChI=1S/C21H26O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,10,12-13,16-19,23H,3,5-9,11H2,1H3/t16-,17+,18+,19-,20-,21-/m0/s1;   InChIKey=SIGSPDASOTUPFS-XUDSTZEESA-N;   SMILES=C(C)[C@@]12[C@]([C@]3([C@](CC1)([C@@]4(C(CC3)=CC(CC4)=O)[H])[H])[H])(C=C[C@]2(C#C)O)[H];   gestinol
 xref: CAS:60282-87-3;   Drug_Central:1291;   HMDB:HMDB0015668
 xref_mesh: MESH:C033273


show annotations for term's descendants           Sort by:
gestodene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Gestodene binds to and results in decreased activity of AR protein; Gestodene binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cp ceruloplasmin multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of CP protein CTD PMID:12616983 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Crp C-reactive protein multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of CRP protein CTD PMID:12616983 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [[Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of CYP1A2 protein] which results in decreased metabolism of tizanidine; [Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of CYP1A2 protein; Gestodene inhibits the reaction [CYP1A2 protein results in increased metabolism of Triazines] CTD PMID:9305587 PMID:16198659 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity		 ISO Gestodene inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)]
Gestodene results in decreased activity of CYP3A4 protein		 CTD PMID:1740010 PMID:2271712 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Gestodene binds to and results in increased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G F10 coagulation factor X multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] affects the activity of F10 protein CTD PMID:11720199 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141 		JBrowse link
G F2 coagulation factor II, thrombin multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of F2 protein; [Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of F2 protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F2 protein CTD PMID:8950781 PMID:15504374 PMID:16522526 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F2r coagulation factor II (thrombin) receptor increases expression EXP Gestodene results in increased expression of F2R mRNA CTD PMID:11733402 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870 		JBrowse link
G F7 coagulation factor VII multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F7 protein; F7 gene polymorphism affects the reaction [[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F7 protein] CTD PMID:8950781 PMID:12616980 PMID:12618251 NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610 		JBrowse link
G F8 coagulation factor VIII multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] affects the activity of F8 protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F8 protein CTD PMID:11720199 PMID:12618251 NCBI chr18:140,848...172,330
Ensembl chr18:140,955...171,857 		JBrowse link
G Fga fibrinogen alpha chain multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:12616980 PMID:12616983 PMID:12618251 NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528 		JBrowse link
G Fgb fibrinogen beta chain multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:12616980 PMID:12616983 PMID:12618251 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979 		JBrowse link
G Fgg fibrinogen gamma chain multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:12616980 PMID:12616983 PMID:12618251 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of FN1 protein CTD PMID:15504374 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Gestodene binds to and affects the activity of PGR protein; Gestodene binds to and results in increased activity of PGR protein CTD PMID:15697108 PMID:25752796 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of PLAT protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased activity of PLAT protein CTD PMID:12618251 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plg plasminogen multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased activity of PLG protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PLG protein CTD PMID:11720199 PMID:12618251 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa multiple interactions
decreases expression
decreases activity		 ISO [Ethinyl Estradiol co-treated with Gestodene] affects the expression of PROC protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased activity of PROC protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PROC; [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PROC protein
Gestodene results in decreased expression of PROC protein
Gestodene results in decreased activity of PROC protein		 CTD PMID:11301170 PMID:11720199 PMID:11994571 PMID:12618251 PMID:12730085 More... NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133 		JBrowse link
G Pros1 protein S multiple interactions
decreases expression		 ISO [Ethinyl Estradiol co-treated with Gestodene] affects the expression of PROS1 protein; [Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of PROS1 protein; [Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of PROS1 protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PROS1
Gestodene results in decreased expression of PROS1 protein		 CTD PMID:8950781 PMID:11720199 PMID:11994571 PMID:12618251 PMID:12730085 More... NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286 		JBrowse link
G Serpinc1 serpin family C member 1 multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of SERPINC1 protein; [Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of SERPINC1 protein CTD PMID:11994571 PMID:12618251 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293 		JBrowse link
G Serpind1 serpin family D member 1 multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of SERPIND1 CTD PMID:15669648 NCBI chr11:83,664,517...83,675,593
Ensembl chr11:83,664,518...83,675,519 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased activity of SERPINE1 protein CTD PMID:15504374 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Shbg sex hormone binding globulin multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of SHBG protein CTD PMID:10899481 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Thbd thrombomodulin multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of THBD protein CTD PMID:8950781 NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193 		JBrowse link
G Vwf von Willebrand factor multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of VWF protein CTD PMID:12616983 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        molecular messenger 18686
          hormone 18507
            sex hormone 18327
              estrogen 18282
                gestodene 26
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            organic molecule 19737
                              organic cyclic compound 19526
                                organic polycyclic compound 17311
                                  steroid 14705
                                    gestodene 26
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