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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gestodene
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Accession:CHEBI:135323 term browser browse the term
Synonyms:related_synonym: Formula=C21H26O2;   InChI=1S/C21H26O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,10,12-13,16-19,23H,3,5-9,11H2,1H3/t16-,17+,18+,19-,20-,21-/m0/s1;   InChIKey=SIGSPDASOTUPFS-XUDSTZEESA-N;   SMILES=C(C)[C@@]12[C@]([C@]3([C@](CC1)([C@@]4(C(CC3)=CC(CC4)=O)[H])[H])[H])(C=C[C@]2(C#C)O)[H];   gestinol
 xref: CAS:60282-87-3;   Drug_Central:1291;   HMDB:HMDB0015668
 xref_mesh: MESH:C033273



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gestodene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Gestodene binds to and results in decreased activity of AR protein; Gestodene binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Cp ceruloplasmin multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of CP protein CTD PMID:12616983 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
JBrowse link
G Crp C-reactive protein multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of CRP protein CTD PMID:12616983 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [[Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of CYP1A2 protein] which results in decreased metabolism of tizanidine; [Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of CYP1A2 protein; Gestodene inhibits the reaction [CYP1A2 protein results in increased metabolism of Triazines] CTD PMID:9305587 PMID:16198659 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO Gestodene inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)]
Gestodene results in decreased activity of CYP3A4 protein
CTD PMID:1740010 PMID:2271712 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Gestodene binds to and results in increased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G F10 coagulation factor X multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] affects the activity of F10 protein CTD PMID:11720199 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
JBrowse link
G F2 coagulation factor II multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of F2 protein; [Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of F2 protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F2 protein CTD PMID:8950781 PMID:15504374 PMID:16522526 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F2r coagulation factor II (thrombin) receptor increases expression EXP Gestodene results in increased expression of F2R mRNA CTD PMID:11733402 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
JBrowse link
G F7 coagulation factor VII multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F7 protein; F7 gene polymorphism affects the reaction [[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F7 protein] CTD PMID:8950781 PMID:12616980 PMID:12618251 NCBI chr16:76,489,779...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G F8 coagulation factor VIII multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] affects the activity of F8 protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F8 protein CTD PMID:11720199 PMID:12618251 NCBI chr18:140,848...172,330
Ensembl chr18:140,955...171,857
JBrowse link
G Fga fibrinogen alpha chain multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:12616980 PMID:12616983 PMID:12618251 NCBI chr 2:168,365,364...168,381,533
Ensembl chr 2:168,374,120...168,381,528
JBrowse link
G Fgb fibrinogen beta chain multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:12616980 PMID:12616983 PMID:12618251 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
JBrowse link
G Fgg fibrinogen gamma chain multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:12616980 PMID:12616983 PMID:12618251 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of FN1 protein CTD PMID:15504374 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Gestodene binds to and affects the activity of PGR protein; Gestodene binds to and results in increased activity of PGR protein CTD PMID:15697108 PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of PLAT protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased activity of PLAT protein CTD PMID:12618251 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Plg plasminogen multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased activity of PLG protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PLG protein CTD PMID:11720199 PMID:12618251 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa multiple interactions
decreases activity
decreases expression
ISO [Ethinyl Estradiol co-treated with Gestodene] affects the expression of PROC protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased activity of PROC protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PROC; [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PROC protein
Gestodene results in decreased activity of PROC protein
Gestodene results in decreased expression of PROC protein
CTD PMID:11301170 PMID:11720199 PMID:11994571 PMID:12618251 PMID:12730085 More... NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
JBrowse link
G Pros1 protein S multiple interactions
decreases expression
ISO [Ethinyl Estradiol co-treated with Gestodene] affects the expression of PROS1 protein; [Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of PROS1 protein; [Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of PROS1 protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PROS1
Gestodene results in decreased expression of PROS1 protein
CTD PMID:8950781 PMID:11720199 PMID:11994571 PMID:12618251 PMID:12730085 More... NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286
JBrowse link
G Serpinc1 serpin family C member 1 multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of SERPINC1 protein; [Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of SERPINC1 protein CTD PMID:11994571 PMID:12618251 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
JBrowse link
G Serpind1 serpin family D member 1 multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of SERPIND1 CTD PMID:15669648 NCBI chr11:83,664,517...83,675,593
Ensembl chr11:83,664,518...83,675,519
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased activity of SERPINE1 protein CTD PMID:15504374 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Shbg sex hormone binding globulin multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of SHBG protein CTD PMID:10899481 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
JBrowse link
G Thbd thrombomodulin multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of THBD protein CTD PMID:8950781 NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193
JBrowse link
G Vwf von Willebrand factor multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of VWF protein CTD PMID:12616983 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        molecular messenger 18301
          hormone 18083
            sex hormone 17979
              estrogen 17905
                gestodene 26
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic polycyclic compound 16570
                                  steroid 13347
                                    gestodene 26
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