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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gestodene
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Accession:CHEBI:135323 term browser browse the term
Synonyms:related_synonym: Formula=C21H26O2;   InChI=1S/C21H26O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,10,12-13,16-19,23H,3,5-9,11H2,1H3/t16-,17+,18+,19-,20-,21-/m0/s1;   InChIKey=SIGSPDASOTUPFS-XUDSTZEESA-N;   SMILES=C(C)[C@@]12[C@]([C@]3([C@](CC1)([C@@]4(C(CC3)=CC(CC4)=O)[H])[H])[H])(C=C[C@]2(C#C)O)[H];   gestinol
 xref: CAS:60282-87-3;   Drug_Central:1291;   HMDB:HMDB0015668
 xref_mesh: MESH:C033273


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gestodene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Gestodene binds to and results in decreased activity of AR protein; Gestodene binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cp ceruloplasmin multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of CP protein CTD PMID:12616983 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Crp C-reactive protein multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of CRP protein CTD PMID:12616983 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [[Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of CYP1A2 protein] which results in decreased metabolism of tizanidine; [Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of CYP1A2 protein; Gestodene inhibits the reaction [CYP1A2 protein results in increased metabolism of Triazines] CTD PMID:9305587 PMID:16198659 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Gestodene binds to and results in increased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G F10 coagulation factor X multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] affects the activity of F10 protein CTD PMID:11720199 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
JBrowse link
G F2 coagulation factor II multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of F2 protein; [Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of F2 protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F2 protein CTD PMID:8950781 PMID:15504374 PMID:16522526 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G F2r coagulation factor II (thrombin) receptor increases expression EXP Gestodene results in increased expression of F2R mRNA CTD PMID:11733402 NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340
JBrowse link
G F7 coagulation factor VII multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F7 protein; F7 gene polymorphism affects the reaction [[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F7 protein] CTD PMID:8950781 PMID:12616980 PMID:12618251 NCBI chr16:81,824,610...81,834,923
Ensembl chr16:81,824,111...81,834,945
JBrowse link
G F8 coagulation factor VIII multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] affects the activity of F8 protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F8 protein CTD PMID:11720199 PMID:12618251 NCBI chr18:367,862...399,242
Ensembl chr18:367,862...399,242
JBrowse link
G Fga fibrinogen alpha chain multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:12616980 PMID:12616983 PMID:12618251 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
JBrowse link
G Fgb fibrinogen beta chain multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:12616980 PMID:12616983 PMID:12618251 NCBI chr 2:182,028,044...182,035,026
Ensembl chr 2:182,027,115...182,038,178
JBrowse link
G Fgg fibrinogen gamma chain multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:12616980 PMID:12616983 PMID:12618251 NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of FN1 protein CTD PMID:15504374 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Gestodene binds to and affects the activity of PGR protein; Gestodene binds to and results in increased activity of PGR protein CTD PMID:15697108 PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of PLAT protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased activity of PLAT protein CTD PMID:12618251 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Plg plasminogen multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased activity of PLG protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PLG protein CTD PMID:11720199 PMID:12618251 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa multiple interactions
decreases activity
decreases expression
ISO [Ethinyl Estradiol co-treated with Gestodene] affects the expression of PROC protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased activity of PROC protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PROC; [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PROC protein
Gestodene results in decreased activity of PROC protein
Gestodene results in decreased expression of PROC protein
CTD PMID:11301170 PMID:11720199 PMID:11994571 PMID:12618251 PMID:12730085 PMID:15669648 NCBI chr18:24,918,402...24,928,822
Ensembl chr18:24,918,398...24,929,091
JBrowse link
G Pros1 protein S multiple interactions
decreases expression
ISO [Ethinyl Estradiol co-treated with Gestodene] affects the expression of PROS1 protein; [Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of PROS1 protein; [Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of PROS1 protein; [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PROS1
Gestodene results in decreased expression of PROS1 protein
CTD PMID:8950781 PMID:11720199 PMID:11994571 PMID:12618251 PMID:12730085 PMID:15669648 PMID:16522526 NCBI chr 7:1,206,648...1,288,140
Ensembl chr 7:1,206,648...1,288,134
JBrowse link
G Serpinc1 serpin family C member 1 multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of SERPINC1 protein; [Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of SERPINC1 protein CTD PMID:11994571 PMID:12618251 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link
G Serpind1 serpin family D member 1 multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of SERPIND1 CTD PMID:15669648 NCBI chr11:87,913,814...87,924,880
Ensembl chr11:87,913,806...87,924,816
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased activity of SERPINE1 protein CTD PMID:15504374 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Shbg sex hormone binding globulin multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of SHBG protein CTD PMID:10899481 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Thbd thrombomodulin multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of THBD protein CTD PMID:8950781 NCBI chr 3:142,748,673...142,752,325
Ensembl chr 3:142,748,674...142,752,325
JBrowse link
G Vwf von Willebrand factor multiple interactions ISO [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of VWF protein CTD PMID:12616983 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
JBrowse link

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  CHEBI ontology 19810
    role 19758
      biological role 19758
        molecular messenger 18275
          hormone 18027
            sex hormone 17908
              estrogen 17847
                gestodene 25
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic polycyclic compound 16393
                                  steroid 12793
                                    gestodene 25
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