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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:vildagliptin
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Accession:CHEBI:135285 term browser browse the term
Synonyms:related_synonym: Formula=C17H25N3O2;   InChI=1S/C17H25N3O2/c18-9-14-2-1-3-20(14)15(21)10-19-16-5-12-4-13(6-16)8-17(22,7-12)11-16/h12-14,19,22H,1-8,10-11H2/t12?,13?,14-,16?,17?/m0/s1;   InChIKey=SYOKIDBDQMKNDQ-XWTIBIIYSA-N;   NVP-LAF237;   SMILES=C1C2CC3(CC1(NCC(N4CCC[C@H]4C#N)=O)CC(C3)C2)O;   galvus;   jalra;   vildagliptin HCl;   vildagliptin hydrochloride;   xiliarx
 xref: CAS:274901-16-5;   Drug_Central:3642;   HMDB:HMDB0015596
 xref_mesh: MESH:C502012

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vildagliptin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol co-treated with vildagliptin] inhibits the reaction [Dietary Fats results in decreased phosphorylation of AKT1 protein]; vildagliptin inhibits the reaction [Dietary Fats results in decreased phosphorylation of AKT1 protein] CTD PMID:28807765 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP [vildagliptin co-treated with 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol] inhibits the reaction [Dietary Fats results in increased expression of BAX protein]; vildagliptin inhibits the reaction [Dietary Fats results in increased expression of BAX protein] CTD PMID:28807765 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP [2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol co-treated with vildagliptin] inhibits the reaction [Dietary Fats results in decreased expression of BCL2 protein]; vildagliptin inhibits the reaction [Dietary Fats results in decreased expression of BCL2 protein] CTD PMID:28807765 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Dpp4 dipeptidylpeptidase 4 decreases activity ISO vildagliptin results in decreased activity of DPP4 protein CTD PMID:17287297 PMID:21388136 NCBI chr 3:48,291,055...48,372,672
Ensembl chr 3:48,291,055...48,372,672 		JBrowse link
G Dpp8 dipeptidylpeptidase 8 decreases activity ISO vildagliptin results in decreased activity of DPP8 protein CTD PMID:17287297 NCBI chr 8:70,521,782...70,576,180
Ensembl chr 8:70,522,092...70,573,424 		JBrowse link
G Insr insulin receptor multiple interactions EXP [2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol co-treated with vildagliptin] inhibits the reaction [Dietary Fats results in decreased phosphorylation of INSR protein]; vildagliptin inhibits the reaction [Dietary Fats results in decreased phosphorylation of INSR protein] CTD PMID:28807765 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol co-treated with vildagliptin] inhibits the reaction [Dietary Fats results in increased phosphorylation of RELA protein]; vildagliptin inhibits the reaction [Dietary Fats results in increased phosphorylation of RELA protein] CTD PMID:28807765 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19770
      atom 19768
        nonmetal atom 19651
          nitrogen atom 18582
            nitrogen molecular entity 18582
              organonitrogen compound 18370
                carboxamide 17208
                  amino acid amide 890
                    vildagliptin 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic group 18602
                              organic divalent group 18593
                                organodiyl group 18593
                                  carbonyl group 18506
                                    carbonyl compound 18506
                                      carboxylic acid 18158
                                        carboacyl group 17412
                                          univalent carboacyl group 17412
                                            carbamoyl group 17208
                                              carboxamide 17208
                                                amino acid amide 890
                                                  vildagliptin 7
paths to the root