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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:clofedanol
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Accession:CHEBI:135207 term browser browse the term
Definition:A diarylmethane that is 2-chlorophenyl(phenyl)methane substituted on the methane carbon by a 2-(dimethylamino)ethyl group. Used in the treatment of dry cough, it suppresses the cough reflex by a direct effect on the cough centre in the medulla of the brain.
Synonyms:exact_synonym: 1-(2-chlorophenyl)-3-(dimethylamino)-1-phenylpropan-1-ol
 related_synonym: Formula=C17H20ClNO;   InChI=1S/C17H20ClNO/c1-19(2)13-12-17(20,14-8-4-3-5-9-14)15-10-6-7-11-16(15)18/h3-11,20H,12-13H2,1-2H3;   InChIKey=WRCHFMBCVFFYEQ-UHFFFAOYSA-N;   SMILES=C(CCN(C)C)(O)(C1=C(Cl)C=CC=C1)C2=CC=CC=C2;   chlophedianol;   clofedanolum
 xref: Beilstein:2813922;   CAS:791-35-5;   DrugBank:DB04837;   Drug_Central:585;   KEGG:D07721
 xref_mesh: MESH:C010432
 xref: PMID:14478530;   PMID:29438107;   Patent:CN101844989;   Reaxys:2813922;   Wikipedia:Clofedanol
 cyclic_relationship: is_conjugate_base_of CHEBI:187895



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clofedanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO clofedanol results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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  CHEBI ontology 19757
    role 19730
      application 19563
        pharmaceutical 19440
          drug 19440
            antitussive 265
              clofedanol 1
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  CHEBI ontology 19757
    subatomic particle 19755
      composite particle 19755
        hadron 19755
          baryon 19755
            nucleon 19755
              atomic nucleus 19755
                atom 19755
                  main group element atom 19703
                    main group molecular entity 19703
                      s-block molecular entity 19557
                        hydrogen molecular entity 19550
                          hydrides 19031
                            inorganic hydride 17955
                              pnictogen hydride 17940
                                nitrogen hydride 17836
                                  azane 17618
                                    ammonia 17617
                                      organic amino compound 17617
                                        tertiary amino compound 9929
                                          clofedanol 1
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