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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bupranolol
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Accession:CHEBI:135123 term browser browse the term
Synonyms:related_synonym: Formula=C14H22ClNO2;   InChI=1S/C14H22ClNO2/c1-10-5-6-12(15)13(7-10)18-9-11(17)8-16-14(2,3)4/h5-7,11,16-17H,8-9H2,1-4H3;   InChIKey=HQIRNZOQPUAHHV-UHFFFAOYSA-N;   SMILES=O(CC(CNC(C)(C)C)O)C1=C(Cl)C=CC(=C1)C;   bupranol;   bupranolol HCl;   bupranolol hydrochloride
 xref: CAS:14556-46-8;   Drug_Central:433;   HMDB:HMDB0015697
 xref_mesh: MESH:D002046


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bupranolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions
decreases activity
ISO [Bupranolol co-treated with ADRB1] results in increased abundance of Cyclic AMP; Bupranolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]
Bupranolol results in decreased activity of ADRB1 protein
CTD PMID:2565296, PMID:12761341, PMID:15060759 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      group 19698
        polyatomic entity 19697
          molecule 19520
            organic molecule 19488
              organic cyclic compound 19285
                organic aromatic compound 19119
                  aromatic ether 15396
                    bupranolol 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      p-block molecular entity 19672
                        carbon group molecular entity 19574
                          organic molecular entity 19563
                            heteroorganic entity 19148
                              organochalcogen compound 18856
                                organooxygen compound 18778
                                  ether 15940
                                    aromatic ether 15396
                                      bupranolol 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.