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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dimemorfan
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Accession:CHEBI:135048 term browser browse the term
Synonyms:related_synonym: Formula=C18H25N;   InChI=1S/C18H25N/c1-13-6-7-14-12-17-15-5-3-4-8-18(15,16(14)11-13)9-10-19(17)2/h6-7,11,15,17H,3-5,8-10,12H2,1-2H3/t15-,17+,18+/m1/s1;   InChIKey=KBEZZLAAKIIPFK-NJAFHUGGSA-N;   SMILES=CN1[C@@]2([C@@]3([C@](CC1)(C=4C(C2)=CC=C(C4)C)CCCC3)[H])[H];   dimemorfan phosphate;   dimemorphan
 xref: CAS:36309-01-0;   Drug_Central:900
 xref_mesh: MESH:C012621


show annotations for term's descendants           Sort by:
dimemorfan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions		 EXP
ISO		 dimemorfan results in decreased expression of CCL2 protein
dimemorfan inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]		 CTD PMID:18173806 PMID:18500357 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases oxidation ISO CYP2B6 protein results in increased oxidation of dimemorfan CTD PMID:19593786 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases oxidation ISO CYP2C19 protein results in increased oxidation of dimemorfan CTD PMID:19593786 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases oxidation
multiple interactions		 ISO CYP2D6 protein results in increased oxidation of dimemorfan
Paroxetine inhibits the reaction [CYP2D6 protein results in increased oxidation of dimemorfan]		 CTD PMID:19593786 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases oxidation
multiple interactions		 ISO CYP3A4 protein results in increased oxidation of dimemorfan
Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of dimemorfan]		 CTD PMID:19593786 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP		 dimemorfan inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS]
dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]		 CTD PMID:15084442 PMID:15723099 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Il1b interleukin 1 beta decreases expression EXP dimemorfan results in decreased expression of IL1B protein CTD PMID:18173806 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO dimemorfan inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; dimemorfan inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGAM protein] CTD PMID:18500357 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP		 dimemorfan inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of JUN]
dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]		 CTD PMID:15084442 PMID:15723099 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO dimemorfan inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] CTD PMID:18500357 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos1 nitric oxide synthase 1 affects expression EXP dimemorfan affects the expression of NOS1 protein CTD PMID:18173806 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
affects expression		 ISO
EXP		 dimemorfan inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
dimemorfan affects the expression of NOS2 protein		 CTD PMID:18173806 PMID:18500357 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO dimemorfan inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and affects the localization of and results in increased activity of RELA protein] CTD PMID:18500357 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 multiple interactions
affects binding		 EXP dimemorfan binds to and results in increased activity of SIGMAR1 protein; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]
dimemorfan binds to SIGMAR1 protein		 CTD PMID:15723099 PMID:18173806 NCBI chr 5:56,904,155...56,907,012
Ensembl chr 5:56,904,159...56,907,017 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 affects activity EXP dimemorfan affects the activity of STAT1 protein CTD PMID:18173806 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO dimemorfan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:18500357 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        biochemical role 19515
          metabolite 19502
            alkaloid 7816
              isoquinoline alkaloid 1194
                morphinane alkaloid 697
                  dimemorfan 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    main group molecular entity 19779
                      p-block molecular entity 19779
                        carbon group molecular entity 19728
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organonitrogen compound 18804
                                alkaloid 7816
                                  isoquinoline alkaloid 1194
                                    morphinane alkaloid 697
                                      dimemorfan 16
paths to the root