Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper VCMap
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:agomelatine
go back to main search page
Accession:CHEBI:134990 term browser browse the term
Synonyms:related_synonym: Formula=C15H17NO2;   InChI=1S/C15H17NO2/c1-11(17)16-9-8-13-5-3-4-12-6-7-14(18-2)10-15(12)13/h3-7,10H,8-9H2,1-2H3,(H,16,17);   InChIKey=YJYPHIXNFHFHND-UHFFFAOYSA-N;   S-20098;   S20098;   SMILES=COC1=CC2=C(C=CC=C2CCNC(C)=O)C=C1;   thymanax;   valdoxan
 xref: CAS:138112-76-2;   Drug_Central:99;   HMDB:HMDB0015636
 xref_mesh: MESH:C084711


show annotations for term's descendants           Sort by:
 
agomelatine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor increases expression EXP
ISO		 S 20098 results in increased expression of BDNF protein
S 20098 results in increased expression of BDNF mRNA		 CTD PMID:19775499 PMID:22160164 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Cat catalase multiple interactions EXP [S 20098 co-treated with Methotrexate] results in increased activity of CAT protein CTD PMID:31975554 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions EXP S 20098 inhibits the reaction [Methotrexate results in increased expression of CSF3 protein] CTD PMID:31975554 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 increases expression EXP S 20098 results in increased expression of DLG4 protein CTD PMID:22160164 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding ISO S 20098 analog binds to HTR2C protein; S 20098 binds to HTR2C protein CTD PMID:22301214 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions EXP S 20098 results in increased expression of and results in increased phosphorylation of MAP2 protein CTD PMID:22160164 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Mtnr1a melatonin receptor 1A multiple interactions
affects binding		 ISO S 20098 analog binds to and results in increased activity of MTNR1A protein
S 20098 binds to MTNR1A protein		 CTD PMID:11063602 PMID:22301214 NCBI chr16:47,144,461...47,163,919
Ensembl chr16:47,144,461...47,163,919 		JBrowse link
G Mtnr1b melatonin receptor 1B multiple interactions
affects binding		 ISO S 20098 analog binds to and results in increased activity of MTNR1B protein
S 20098 binds to MTNR1B protein		 CTD PMID:11063602 PMID:22301214 NCBI chr 8:12,638,219...12,652,737
Ensembl chr 8:12,638,219...12,652,737 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP S 20098 inhibits the reaction [Methotrexate results in increased expression of NOS2 protein] CTD PMID:31975554 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression ISO S 20098 results in increased expression of NR3C1 mRNA CTD PMID:19775499 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B affects expression EXP S 20098 affects the expression of PPP1R9B protein CTD PMID:22160164 NCBI chr10:79,938,055...79,954,085
Ensembl chr10:79,938,066...79,954,083 		JBrowse link
G Slc6a15 solute carrier family 6 member 15 multiple interactions ISO [Caffeine co-treated with S 20098] results in decreased expression of SLC6A15 mRNA CTD PMID:29882086 NCBI chr 7:38,553,055...38,607,239
Ensembl chr 7:38,553,196...38,607,239 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP S 20098 inhibits the reaction [Methotrexate results in increased expression of SPP1 protein] CTD PMID:31975554 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Syp synaptophysin increases expression EXP S 20098 results in increased expression of SYP protein CTD PMID:22160164 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          nitrogen atom 18767
            nitrogen molecular entity 18767
              organonitrogen compound 18544
                carboxamide 17285
                  acetamides 12410
                    agomelatine 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        carboacyl group 17469
                                          univalent carboacyl group 17469
                                            carbamoyl group 17285
                                              carboxamide 17285
                                                acetamides 12410
                                                  agomelatine 14
paths to the root