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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:134870 term browser browse the term
Definition:A racemate consisting of equimolar amounts of (R)- and (S)-toloxatone. It is a reversible monoamine oxidase A inhibitor and antidepressant.
Synonyms:exact_synonym: rac-5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one
 related_synonym: (5RS)-5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one;   (RS)-toloxatone;   Delalande 69276;   Formula=C11H13NO3;   MD-69276;   MD69276;   Perenum;   humoryl;   rac-5-(hydroxymethyl)-3-(3-methylphenyl)-2-oxazolidinone;   rac-5-hydroxymethyl-3-(m-tolyl)-2-oxazolidinone;   rac-toloxatone;   racemic toloxatone;   toloxatona;   toloxatonum
 xref: CAS:29218-27-7;   DrugBank:DB09245;   Drug_Central:2702;   KEGG:D02559
 xref_mesh: MESH:C010798
 xref: PMID:10371410;   PMID:1221563;   PMID:12659549;   PMID:1352813;   PMID:1424410;   PMID:1546124;   PMID:1546145;   PMID:1705137;   PMID:1843597;   PMID:2353326;   PMID:2365178;   PMID:2768411;   PMID:29844717;   PMID:32935716;   PMID:3634492;   PMID:3810545;   PMID:409416;   PMID:41906;   PMID:494659;   PMID:551645;   PMID:6520180;   PMID:6633672;   PMID:7200786;   PMID:7884022;   PMID:8094790;   PMID:8436164;   Patent:US4699782;   Reaxys:527506;   Wikipedia:Toloxatone

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toloxatone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Maoa monoamine oxidase A decreases activity EXP toloxatone results in decreased activity of MAOA protein CTD PMID:15178694 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    chemical entity 19761
      chemical substance 12190
        mixture 11141
          racemate 10073
            toloxatone 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic molecule 19493
                              organic cyclic compound 19318
                                carbocyclic compound 18296
                                  benzenoid aromatic compound 17400
                                    benzenes 17172
                                      toluenes 6249
                                        5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one 1
                                          (R)-toloxatone 1
                                            toloxatone 1
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